Understanding bone health in people with type 1 diabetes and kidney disease
Official title: Skeletal Health in Type 1 Diabetes and the Role of Diabetic Kidney Disease
Funded at Northern California Institute/res/edu · NIH-10684140 · Data updated 2026-11-12
This study is looking at how type 1 diabetes and kidney problems can affect bone health and increase the risk of fractures, so we can find better ways to help people with diabetes keep their bones strong and healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 10, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $669,183 |
| NIH project number | 5R01DK125646-04 |
| Project ID | NIH-10684140 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 1 diabetes, especially those experiencing diabetic kidney disease.
✕Less likely to help
Patients without type 1 diabetes or those who do not have any kidney complications may not benefit from this research.
What this research studies
This research investigates how type 1 diabetes affects bone health, particularly focusing on the role of diabetic kidney disease in increasing fracture risk. It aims to identify factors that contribute to skeletal fragility beyond just bone density, such as bone quality and the effects of kidney complications. By analyzing data from participants with type 1 diabetes, the study seeks to uncover the relationship between kidney function and bone health, which could lead to better prevention strategies for fractures in this population.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing fractures in individuals with type 1 diabetes, particularly those with kidney disease.
How similar studies have gone: Previous research has indicated that understanding the interplay between diabetes and bone health can lead to significant advancements in patient care, suggesting that this approach has potential for success.
Where this research is happening
-
Northern California Institute/res/edu
San Francisco, United States Active
Researchers
- Principal investigator: Schafer, Anne Louise — Northern California Institute/res/edu
- Study coordinator: Schafer, Anne Louise
Related research
Other NIH-funded projects on the same topics.
-
Understanding protective factors in kidney disease for type 1 diabetes patients
This study is looking at how certain cells in the skin might help protect people with type 1 diabetes from kidney problems, and it hopes to find new ways to improve treatment for those at risk of diabetic kidney disease.
-
PFAS exposure and kidney disease risk in teens with type 2 diabetes
Aging and kidney health study in youths with type 2 diabetes to see how a common chemical (PFAS) affects kidney risk and how to prevent or treat it.
-
New kidney biomarkers to catch type 1 diabetes kidney disease early
This study looks for tiny clues in urine and blood that predict kidney trouble early in people with type 1 diabetes.
-
How type 1 diabetes changes the kidneys today
This project uses modern kidney biopsies and advanced molecular tests to look for energy and oxygen problems in the kidneys of adults with type 1 diabetes.
-
Understanding how PFAS chemicals affect kidney disease in young people with Type 2 diabetes
This project looks at how common chemicals called PFAS might contribute to kidney problems in young people with Type 2 diabetes.
-
Understanding kidney disease in type 1 diabetes through modern biopsy techniques
This study is looking at how type 1 diabetes affects kidney health over time by examining kidney tissue from people with diabetic kidney disease, so we can better understand the condition and improve treatment options.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.