How inflammatory cells activate a system that affects kidney disease in diabetes
Official title: Novel mechanism of activation of the Renin-Angiotensin-System by inflammatory cells in diabetic kidney disease
Funded at Wayne State University · NIH-11013359 · Data updated 2026-11-12
This study is looking at how certain immune cells in the kidneys might be affecting a system that can worsen kidney problems in people with diabetes, and it aims to find new ways to help treat these issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | January 25, 2024 |
| Project end | April 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $173,250 |
| NIH project number | 5R21DK138393-02 |
| Project ID | NIH-11013359 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type-1 diabetes who are experiencing kidney disease or related complications.
✕Less likely to help
Patients without diabetes or those with kidney disease from non-diabetic causes may not benefit from this research.
What this research studies
This research investigates how inflammatory cells contribute to the activation of the renin-angiotensin system, which plays a significant role in diabetic kidney disease. By examining diabetic mice, the study aims to identify specific inflammatory cell types and their locations in the kidneys, using advanced techniques like single-cell RNA sequencing and mass cytometry. The researchers will also explore the effects of interleukin-17 on renin release from kidney cells, potentially uncovering new pathways that could be targeted for treatment. This work could lead to a better understanding of kidney disease mechanisms in diabetes and inform future therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve kidney function and overall health for patients with diabetic kidney disease.
How similar studies have gone: Previous research has shown that targeting the renin-angiotensin system can improve kidney function in diabetic patients, suggesting that this approach may yield significant insights.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Mendez, Mariela — Wayne State University
- Study coordinator: Mendez, Mariela
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.