Investigating the protective role of a cholesterol metabolite in diabetic kidney disease.
Protective role of CH25h/25-HC in diabetic kidney disease.
This study is looking at how a specific protein and its byproduct might impact kidney health in people with diabetic kidney disease, hoping to find new ways to help improve kidney function for those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11052023 on NIH RePORTER |
What this research studies
This research focuses on understanding how cholesterol 25-hydroxylase (CH25H) and its product, 25-hydroxycholesterol (25-HC), affect kidney health in patients with diabetic kidney disease (DKD). By studying animal models that mimic early DKD, researchers aim to uncover the mechanisms by which CH25H influences endothelial cell function and inflammation in the kidneys. The goal is to clarify the role of CH25H in kidney pathology and potentially identify new therapeutic targets for improving kidney health in diabetic patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with diabetic kidney disease.
Not a fit: Patients without diabetes or those with advanced kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect kidney function in patients with diabetes.
How similar studies have performed: While the role of CH25H in kidney disease is not well-defined, preliminary data suggests that similar approaches have shown promise in understanding kidney pathology.
Where this research is happening
Bronx, United States
- James J Peters VA Medical Center — Bronx, United States (Active)
Researchers
- Principal investigator: He, John Cijiang — James J Peters VA Medical Center
- Study coordinator: He, John Cijiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.