Genetic discovery for diabetic kidney disease in adults
Official title: A functional genomics pipeline for genetic discovery in diabetic kidney disease
Funded at Broad Institute, INC. · NIH-11399693 · Data updated 2026-11-12
A scientist team is studying the genes that influence diabetic kidney disease in adults to better understand why some people develop it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | August 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $615,979 |
| NIH project number | 5R01DK132299-05 |
| Project ID | NIH-11399693 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with type 1 or type 2 diabetes who are at risk for or have developed diabetic kidney disease.
✕Less likely to help
People without diabetes or with DKD who do not contribute genetic data to the study sites may not directly benefit.
What this research studies
This project builds on an international effort to collect genetic and health data from about 150,000 adults with diabetes who have or do not have kidney disease. Using large-scale genetic analysis, researchers aim to identify genetic factors that increase or reduce DKD risk in both type 1 and type 2 diabetes. The goal is to uncover new biological insights that could guide future therapies and personalized care. The work leverages existing collaborations and a vast biobank to increase statistical power and reliability of findings.
Why it matters
Potential benefit: If successful, findings could lead to new targets for drugs or strategies to prevent DKD in people with diabetes.
How similar studies have gone: Previous GWAS efforts have identified new signals; this project aims to greatly expand sample size to confirm and refine those findings.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Hirschhorn, Joel N — Broad Institute, INC.
- Study coordinator: Hirschhorn, Joel N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.