Understanding the genetic factors behind Diabetic Kidney Disease
Official title: Genetic risk and molecular characterization of Diabetic Kidney Disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-11066521 · Data updated 2026-11-12
This study is looking at how genes might play a role in Diabetic Kidney Disease, which can lead to kidney failure, by using mice to find out which genes affect kidney health in diabetes, with the hope of discovering new treatments for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 5, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $338,000 |
| NIH project number | 5R01DK139395-02 |
| Project ID | NIH-11066521 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who are at risk of developing kidney disease.
✕Less likely to help
Patients without diabetes or those who do not have a genetic predisposition to kidney disease may not benefit from this research.
What this research studies
This research investigates the genetic basis of Diabetic Kidney Disease (DKD), which is a major cause of kidney failure. By using mouse models that are susceptible and resistant to DKD, the study aims to identify genetic factors that contribute to the disease. The researchers will explore how certain genes, particularly those related to oxidative stress, affect kidney health in the context of diabetes. This work may lead to new insights into potential therapies for DKD.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that prevent or treat Diabetic Kidney Disease, improving kidney health for patients with diabetes.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors in kidney diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Daehn, Ilse Sofia — Icahn School of Medicine at Mount Sinai
- Study coordinator: Daehn, Ilse Sofia
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.