Investigating the role of a specific protein in kidney disease related to diabetes
Official title: Role of RARRES1 in diabetic kidney disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-10883725 · Data updated 2026-11-12
This study is looking at how a protein called RARRES1 impacts kidney health in people with diabetic kidney disease, and it hopes to find new ways to help manage this condition by using tissue samples from patients and experiments with mice.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 4, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $429,081 |
| NIH project number | 5R01DK129467-04 |
| Project ID | NIH-10883725 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with diabetic kidney disease or primary glomerular diseases.
✕Less likely to help
Patients without diabetic kidney disease or those with other unrelated kidney conditions may not benefit from this research.
What this research studies
This research focuses on understanding how the protein RARRES1 affects kidney health in patients with diabetic kidney disease (DKD). By analyzing human kidney tissue samples and using experimental mouse models, the study aims to uncover the protective and harmful roles of retinoic acid signaling in kidney cells. The goal is to validate previous findings from animal studies in humans, which could lead to new therapeutic strategies for managing kidney disease. Patients may be involved in providing tissue samples or data to help advance this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect kidney function in patients with diabetic kidney disease.
How similar studies have gone: Previous studies have shown promising results in animal models regarding the protective effects of retinoic acid, but this research aims to confirm these findings in humans.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Lee, Kyung — Icahn School of Medicine at Mount Sinai
- Study coordinator: Lee, Kyung
Related research
Other NIH-funded projects on the same topics.
-
siRNA nanoparticle treatment to stop diabetic kidney damage
A new nanoparticle-delivered gene-silencing treatment aims to lower kidney inflammation in people with diabetes to help protect their kidneys.
-
LRG1’s role in diabetic kidney disease and kidney fibrosis
A study examines how a specific protein, LRG1, influences kidney disease related to diabetes and its scarring, with the aim of finding targeted ways to slow or prevent damage.
-
Genetic discovery for diabetic kidney disease in adults
A scientist team is studying the genes that influence diabetic kidney disease in adults to better understand why some people develop it.
-
Non-canonical NF-kB and inflammation in diabetic kidney disease
A study to understand how a specific inflammatory pathway worsens kidney disease in adults with type 2 diabetes and how it might be treated.
-
Epidermal microfluidic screen to detect diabetic kidney disease
A new skin-based microfluidic test platform may help identify kidney complications in people with diabetes using real-time biomarkers from sweat and glucose data.
-
PFAS exposure and kidney disease risk in teens with type 2 diabetes
Aging and kidney health study in youths with type 2 diabetes to see how a common chemical (PFAS) affects kidney risk and how to prevent or treat it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.