Investigating the role of a specific protein in kidney disease related to diabetes
Role of RARRES1 in diabetic kidney disease
This study is looking at how a protein called RARRES1 impacts kidney health in people with diabetic kidney disease, and it hopes to find new ways to help manage this condition by using tissue samples from patients and experiments with mice.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10883725 on NIH RePORTER |
What this research studies
This research focuses on understanding how the protein RARRES1 affects kidney health in patients with diabetic kidney disease (DKD). By analyzing human kidney tissue samples and using experimental mouse models, the study aims to uncover the protective and harmful roles of retinoic acid signaling in kidney cells. The goal is to validate previous findings from animal studies in humans, which could lead to new therapeutic strategies for managing kidney disease. Patients may be involved in providing tissue samples or data to help advance this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with diabetic kidney disease or primary glomerular diseases.
Not a fit: Patients without diabetic kidney disease or those with other unrelated kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect kidney function in patients with diabetic kidney disease.
How similar studies have performed: Previous studies have shown promising results in animal models regarding the protective effects of retinoic acid, but this research aims to confirm these findings in humans.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Lee, Kyung — Icahn School of Medicine at Mount Sinai
- Study coordinator: Lee, Kyung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.