Using NAD supplements to treat kidney disease in diabetes patients
NAD Augmentation to Treat Diabetic Kidney Disease: A Randomized Controlled Trial
This study is looking at whether taking a supplement called NMN can help improve kidney health and lower signs of damage in people with diabetic kidney disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10906074 on NIH RePORTER |
What this research studies
This research investigates the effects of NAD augmentation through nicotinamide mononucleotide (NMN) supplementation on diabetic kidney disease (DKD). The study aims to determine if NMN can reduce urinary albumin levels, which are indicative of kidney damage, and improve overall kidney function. Participants will be randomly assigned to receive either NMN or a placebo, allowing researchers to compare the outcomes effectively. The approach is based on previous findings that suggest NAD levels are linked to kidney health and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with diabetes and are experiencing early signs of diabetic kidney disease.
Not a fit: Patients who do not have diabetes or those with advanced kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option that significantly improves kidney health and reduces the risk of end-stage kidney disease in diabetic patients.
How similar studies have performed: Previous studies have shown promising results with NAD augmentation in animal models, suggesting potential for success in human trials.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Bhasin, Shalender — Brigham and Women's Hospital
- Study coordinator: Bhasin, Shalender
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.