Understanding how genes affect tooth development and cavity risk
Official title: Molecular Signaling in Dentinogenesis and Dental Caries Risk
Funded at University of Pittsburgh at Pittsburgh · NIH-11038662 · Data updated 2026-11-12
This study is looking at how certain genes, especially one called TRPS1, might affect how children's teeth develop and their chances of getting cavities, with the hope of finding ways to help prevent tooth decay based on each child's unique genetic makeup.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 19, 2024 |
| Project end | September 18, 2026 |
| Funding year | 2024 |
| Award (this year) | $296,734 |
| NIH project number | 1R03DE034501-01 |
| Project ID | NIH-11038662 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children under 11 years old who may have genetic predispositions to dental caries.
✕Less likely to help
Patients who do not have genetic risk factors for dental caries or who are over the age of 11 may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence the development of teeth and the risk of dental cavities, particularly in children. By focusing on the role of a specific gene, TRPS1, which is linked to tooth mineralization, the study aims to uncover how variations in this gene can lead to increased susceptibility to cavities. The research will involve analyzing genetic data and conducting experiments to better understand the biological processes involved in tooth formation and decay. Ultimately, the goal is to develop personalized prevention strategies for dental caries based on individual genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized strategies for preventing dental cavities in children.
How similar studies have gone: Previous research has shown success in identifying genetic risk factors for dental caries, making this approach a continuation of established findings.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Socorro, Mairobys — University of Pittsburgh at Pittsburgh
- Study coordinator: Socorro, Mairobys
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.