Understanding how genes affect tooth development and cavity risk
Molecular Signaling in Dentinogenesis and Dental Caries Risk
This study is looking at how certain genes, especially one called TRPS1, might affect how children's teeth develop and their chances of getting cavities, with the hope of finding ways to help prevent tooth decay based on each child's unique genetic makeup.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11038662 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence the development of teeth and the risk of dental cavities, particularly in children. By focusing on the role of a specific gene, TRPS1, which is linked to tooth mineralization, the study aims to uncover how variations in this gene can lead to increased susceptibility to cavities. The research will involve analyzing genetic data and conducting experiments to better understand the biological processes involved in tooth formation and decay. Ultimately, the goal is to develop personalized prevention strategies for dental caries based on individual genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include children under 11 years old who may have genetic predispositions to dental caries.
Not a fit: Patients who do not have genetic risk factors for dental caries or who are over the age of 11 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized strategies for preventing dental cavities in children.
How similar studies have performed: Previous research has shown success in identifying genetic risk factors for dental caries, making this approach a continuation of established findings.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Socorro, Mairobys — University of Pittsburgh at Pittsburgh
- Study coordinator: Socorro, Mairobys
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.