Vitamin D supplementation for dental caries treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effects of vitamin D supplementation and topical fluorides on the progression of initial carious lesions in individuals with vitamin D deficiency. Participants aged 12 to 45 with at least two clinically diagnosed initial carious lesions will be randomly assigned to one of three groups: one receiving vitamin D and oral hygiene instructions, another receiving vitamin D, topical fluorides, and oral hygiene instructions, and a control group receiving topical fluorides and oral hygiene instructions. The study will assess changes in caries detection scores, salivary protein concentrations, and cariogenic microbes over a six-month period. Data will be collected through clinical assessments and laboratory analyses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients of all genders and ages ranging from 12-50 years, having at least two teeth with clinically diagnosed Initial Carious Lesions at Moderate Risk of Dental Caries, after written informed consent.
* Patients having vitamin D deficiency.

Exclusion Criteria:

* Patients who have heavy calculus, gingivitis, or periodontitis.
* Patients using desensitizing toothpaste or mouthwash up to six weeks before the study.
* Patients who have severe intestine or kidney disease, malabsorption syndrome, or any other conditions affecting vitamin D metabolism.
* Patients on antibiotics or probiotics therapy for the last month
* Pregnant females.
* Patients with poor oral hygiene and with excessive dietary exposure to acids and carbohydrates.

Where it's running

• Dr Saba Arshad
  Karachi, Sindh, Pakistan Recruiting

Study contacts

• Principal investigator: Dr Saba Arshad — Duhs
• Study coordinator: Dr Saba Arshad
• Email: saba.arshad@duhs.edu.pk
• Phone: 02138771111

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Silver Diamine Fluoride for Caries in Baby Teeth in Routine Dental Care

  This study tests whether applying 38% silver diamine fluoride in everyday dental practice can stop decay in primary teeth of children 14 and younger.

  Recruiting Consorci Sanitari de l'Alt Penedès i Garraf · Vilanova i la Geltrú, Barcelona · NCT07926828

• Nano Silver Fluoride vs. Silver Diamine Fluoride for Kids’ Cavities

  This study tests whether Nano Silver Fluoride can stop decay in children as well as Silver Diamine Fluoride.

  Recruiting A.T. Still University of Health Sciences · Mesa, Arizona · NCT07861321

• Early detection of initial caries with fluorescent starch nanoparticles versus salivary biomarkers

  This study tests whether fluorescent starch nanoparticles can detect early tooth decay earlier than salivary biomarkers in people with suspected initial enamel caries.

  Recruiting Menoufia University · Shibīn al Kawm, Menoufia · NCT07732127

• Digital Caries Risk Questionnaire: does it match CAMBRA in Egyptian adults

  A digital self‑administered caries risk questionnaire is being tested to see how well it matches the CAMBRA risk assessment in Egyptian adults who visit the dentist.

  Recruiting October University for Modern Sciences and Arts · Giza, Sixth of October · NCT07716254

• First permanent molars restored with Cention N in children

  This trial tests whether restoring both first permanent molars with Cention N in children aged 8-10 is beneficial for clinical results, x-ray findings, and daily oral health quality of life over 12 months.

  Recruiting Minia University · Minya, Asyut Governorate · NCT07703176

• Ozone therapy to boost remineralization of early caries in kids

  This study tests whether adding ozone therapy to a remineralizing gel helps children aged 6–12 remineralize early, non-cavitated caries lesions better than the gel alone.

  Recruiting Marmara University · Istanbul, Maltepe · NCT07671651

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.