Effect of Silver Diamine Fluoride on Oral Microbiome in Children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of silver diamine fluoride (SDF) and a combination of SDF with potassium iodide (SDF+KI) on dental caries in healthy children aged 4-10. The study aims to evaluate the effectiveness of these treatments in arresting caries and their effects on the oral microbiome. Participants will receive one of the two treatments and return for follow-up assessments to analyze changes in saliva composition and microbial inhabitants. The research is conducted at King Abdulaziz University with informed consent from parents.

Why it matters

Who can join: the full rules

Inclusion criteria

* Healthy patients.
* Patients within 4-10 years of age.
* The presence of at least one deciduous tooth with a caries lesion that is directly accessible (cavitates)

Exclusion Criteria:

* Presentation of irreversible pulpititis or necrosis• The extensive lesion was restored.
* The surface of the lesion was hard and smooth.
* Children with inherited or systemic conditions.
* Children with a substantial medication history or those who have taken antibiotics within the previous three months.
* Children who have undergone topical fluoride treatment within the previous 2 weeks.

Where it's running

• University Dental hospital of King Abdulaziz University
  Jeddah, Mecca Region, Saudi Arabia Recruiting

Study contacts

• Study coordinator: Dr.Doaa Y Jamal, BDS, MSc, SBPD
• Email: Djamal0004@stu.kau.edu.sa
• Phone: (+966)-558887632

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Ozone therapy to boost remineralization of early caries in kids

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• Dental health in children with specific learning disabilities

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  Recruiting Alanya Alaaddin Keykubat University · Alanya, Antalya · NCT07611981

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.