Silver diamine fluoride vs fluoride varnish to lower Streptococcus mutans in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized split-mouth trial enrolls cooperative children aged 3–8 who have at least two contralateral primary molars with active dentin caries. Each child receives 38% silver diamine fluoride on one side and 5% sodium fluoride varnish on the opposite side, with side allocation randomized. The primary outcome is change in Dentocult SM Strip Mutans scores in plaque measured over three months, and secondary outcomes include plaque index, bleeding on probing, and adverse events. Treatments and plaque assessments are conducted at the dental clinic at Assiut University.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 3-8 years; cooperative (Frankl ≥2).
* ≥2 contralateral primary molars with active dentin caries (ICDAS 3-5) of comparable severity.
* Parent/guardian consent; child assent when appropriate.

Exclusion Criteria:

* Silver allergy; ulcerative gingivitis/stomatitis.
* Systemic antibiotics within 4 weeks.
* Fixed appliances interfering with plaque assessment.
* Conditions precluding safe participation per clinician judgment.

Where it's running

• Assiut University
  Asyut, Asyut Governorate, Egypt Recruiting

Study contacts

• Study coordinator: ِAhmed Kamel soliman, PHD
• Email: a.k.soliman@hotmail.com
• Phone: +201061553007

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Silver Diamine Fluoride for Caries in Baby Teeth in Routine Dental Care

  This study tests whether applying 38% silver diamine fluoride in everyday dental practice can stop decay in primary teeth of children 14 and younger.

  Recruiting Consorci Sanitari de l'Alt Penedès i Garraf · Vilanova i la Geltrú, Barcelona · NCT07926828

• Nano Silver Fluoride vs. Silver Diamine Fluoride for Kids’ Cavities

  This study tests whether Nano Silver Fluoride can stop decay in children as well as Silver Diamine Fluoride.

  Recruiting A.T. Still University of Health Sciences · Mesa, Arizona · NCT07861321

• Digital Caries Risk Questionnaire: does it match CAMBRA in Egyptian adults

  A digital self‑administered caries risk questionnaire is being tested to see how well it matches the CAMBRA risk assessment in Egyptian adults who visit the dentist.

  Recruiting October University for Modern Sciences and Arts · Giza, Sixth of October · NCT07716254

• First permanent molars restored with Cention N in children

  This trial tests whether restoring both first permanent molars with Cention N in children aged 8-10 is beneficial for clinical results, x-ray findings, and daily oral health quality of life over 12 months.

  Recruiting Minia University · Minya, Asyut Governorate · NCT07703176

• Ozone therapy to boost remineralization of early caries in kids

  This study tests whether adding ozone therapy to a remineralizing gel helps children aged 6–12 remineralize early, non-cavitated caries lesions better than the gel alone.

  Recruiting Marmara University · Istanbul, Maltepe · NCT07671651

• Dental health in children with specific learning disabilities

  This study will test the dental caries and oral hygiene of 7–12 year-olds with specific learning disabilities and compare them with healthy peers.

  Recruiting Alanya Alaaddin Keykubat University · Alanya, Antalya · NCT07611981

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.