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Chemotherapy Effect clinical trials and research

• 39Clinical trials
• 14Countries

Newest Chemotherapy Effect clinical trials

All recruiting trials (39)

• Adding silibinin to standard daunorubicin or idarubicin therapy for newly diagnosed non‑M3 acute myeloid leukemia

  This trial will test whether adding silibinin (a liver‑protecting compound) to standard daunorubicin or idarubicin chemotherapy helps people with newly diagnosed non‑M3 acute myeloid leukemia.

  Recruiting Phase 4 Fujian Medical University Union Hospital · Fuzhou, Fujian · NCT07561892

• Camrelizumab plus apatinib with or without FOLFOX chemotherapy for advanced liver cancer

  This research will test whether adding FOLFOX chemotherapy to camrelizumab plus apatinib helps adults with advanced hepatocellular carcinoma who have not received prior systemic treatment.

  Recruiting Phase 3 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07267806

• Personalized management for borderline resectable and locally advanced pancreatic cancer

  This study is testing if giving chemotherapy first can help people with borderline resectable and locally advanced pancreatic cancer have surgery and improve their chances of survival.

  Recruiting Oslo University Hospital · Bergen, Norway and 4 other locations · NCT06944587

• Impact of massage therapy on sleep in young cancer patients

  This study is testing whether personalized massage therapy can help young cancer patients in the hospital sleep better and feel less tired, anxious, and in pain during their treatment.

  Recruiting Children's Hospital of Philadelphia · Washington D.C., District of Columbia and 1 other locations · NCT06892158

• Comparing treatments for oral mucositis in children undergoing chemotherapy

  This study tests whether sodium bicarbonate, saline, or black mulberry syrup can help reduce mouth sores in children aged 6-18 who are getting chemotherapy.

  Recruiting Burdur Mehmet Akif Ersoy University · Isparta · NCT06525402

• Assessing long-term dental effects of chemotherapy in childhood cancer survivors

  This study looks at the long-term dental health of childhood cancer survivors who had chemotherapy to see if they have more dental problems compared to kids who didn’t have cancer.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Brussels · NCT06517927

• Perioperative oxaliplatin plus S-1 with H. pylori eradication for locally advanced gastric and gastroesophageal junction adenocarcinoma

  This trial tests whether adding a 14-day H. pylori eradication regimen to perioperative oxaliplatin plus S-1 chemotherapy helps people with H. pylori–positive resectable locally advanced gastric or gastroesophageal junction cancer.

  Recruiting Phase 2 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou · NCT06510010

• Predicting how well chemotherapy will work for esophageal cancer patients

  This study is testing if DNA changes in biopsy samples can help doctors predict how well chemotherapy will work for patients with esophageal cancer, so those who might not benefit can avoid unnecessary treatment.

  Recruiting City of Hope Medical Center · Chūō, Yamanashi · NCT06490003

• Predicting how well gastric cancer patients respond to chemotherapy using AI

  This study tests if using AI to combine imaging and tissue data can help predict how well advanced gastric cancer patients will respond to chemotherapy.

  Recruiting Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT06451393

• Combining liver-directed therapy (HAI pump or SIRT) with GemOx chemotherapy for unresectable intrahepatic cholangiocarcinoma (TOMCAT)

  This trial will test whether adding a liver-directed treatment (either a hepatic artery infusion pump delivering floxuridine or selective internal radiation therapy) to GemOx chemotherapy helps shrink or control intrahepatic cholangiocarcinoma that cannot be removed by surgery.

  Recruiting Phase 2 Oslo University Hospital · Oslo, Oslo · NCT06313203

• Evaluating anti-EGFR therapy effectiveness in specific colorectal cancer patients

  This study is testing if a personalized treatment approach using anti-EGFR therapy can help people with left-sided RAS-wild type metastatic colorectal cancer do better than standard chemotherapy.

  Recruiting at 3 sites Phase 3 City Clinical Oncology Hospital No 1 · Moscow and 2 other locations · NCT06226857

• Comparing two treatment methods for advanced liver cancer

  This study is testing two different treatment methods for advanced liver cancer to see which one helps patients feel better and live longer.

  Recruiting Phase 3 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT06172205

• Comparing chemotherapy and surgery for rectal cancer after local resection

  This study is testing whether chemotherapy or surgery works better for people with intermediate-risk rectal cancer who have already had part of their tumor removed.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT06043999

• Comparing two treatment approaches for liver cancer

  This study is testing two different treatment plans for liver cancer to see which one helps patients live longer and have better outcomes.

  Recruiting Phase 3 Sun Yat-sen University · Guangzhou, Guangdong · NCT06041477

• Comparing two treatments for metastatic hormone-sensitive prostate cancer

  This study is testing if adding chemotherapy to a hormone treatment can help men with advanced prostate cancer live longer compared to just using hormone treatment alone.

  Recruiting Phase 3 The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT05983783

• Using a smartphone brain-training app to reduce chemo‑brain in gynecologic cancer patients

  This will test whether a mobile cognitive training app can reduce chemo‑brain symptoms in people with gynecologic cancers who are receiving chemotherapy.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05864274

• Neoadjuvant therapy followed by local treatment for recurrent colorectal liver metastases

  This study is testing if giving a new treatment before local therapy can help people with recurrent colorectal liver cancer live longer compared to getting local therapy right away.

  Recruiting Phase 3 Amsterdam UMC, location VUmc · Amsterdam · NCT05861505

• Comparing chemotherapy and observation for liver metastasis in colorectal cancer

  This study is testing if some patients with liver metastasis from colorectal cancer can safely skip chemotherapy after surgery and just be monitored instead.

  Recruiting Phase 3 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT05815082

• Comparing sequential S-1 therapy after surgery for advanced gastric cancer

  This study is testing if a specific treatment plan using S-1 therapy after surgery can help people with advanced stomach cancer recover better.

  Recruiting Phase 3 Zhejiang University · Hanzhou, Zhejiang · NCT05813015

• Combining targeted therapy with chemotherapy for advanced colorectal cancer

  This study is testing if adding a targeted therapy to standard chemotherapy can help people with advanced colorectal cancer live longer without their cancer coming back after surgery.

  Recruiting Phase 3 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT05797467

• Comparing two treatment approaches for esophageal squamous cell carcinoma

  This study is testing whether adding extra chemotherapy to standard treatment can help people with inoperable esophageal squamous cell carcinoma live longer and feel better.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT05775419

• Understanding biomarkers in metastatic colorectal cancer treatment

  This study is trying to see how cancer changes during treatment in people with metastatic colorectal cancer and whether certain genetic markers can help tailor better treatment options for them.

  Recruiting at 2 sites Region Skane · Lund, Skåne County and 1 other locations · NCT05755672

• Effects of socio-aesthetic care on anxiety in cancer patients undergoing chemotherapy

  This study tests if special care focused on appearance and social support can help reduce anxiety in cancer patients going through chemotherapy.

  Recruiting GCS Ramsay Santé pour l'Enseignement et la Recherche · Valence · NCT05649852

• Using metronomic temozolomide for patients with advanced neuroendocrine tumors who are unfit for standard treatments

  This study is testing if a continuous low-dose chemotherapy called metronomic temozolomide can help people with advanced neuroendocrine tumors who can't tolerate standard treatments feel better and live longer.

  Recruiting Phase 2 European Institute of Oncology · Milan · NCT05554003

• Using Simvastatin to Improve Treatment for Triple Negative Breast Cancer

  This study is testing if adding simvastatin to chemotherapy can help women with advanced triple-negative breast cancer respond better to treatment.

  Recruiting Phase 2 Universitas Indonesia · Jakarta Pusat, DKI Jakarta · NCT05550415

• Implementation program for advanced pancreatic cancer care

  This program is testing new ways to improve treatment and survival rates for people with locally advanced pancreatic cancer in the Netherlands by using the best practices from around the world.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT05524090

• Using magnetic markers to locate breast cancer and lymph nodes after chemotherapy

  This study is testing if using tiny magnetic seeds can help doctors find and remove breast cancer and lymph nodes more accurately in patients after they have chemotherapy.

  Recruiting The University of Hong Kong · Hong Kong · NCT05427071

• Testing drug sensitivity in micro tumors to guide treatment for colorectal cancer

  This study is testing whether a new 3D drug sensitivity test on tiny tumors can help guide better treatment decisions for people with colorectal cancer after surgery.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT05424692

• Assessing survival and quality of life in patients with advanced pancreatic cancer

  This study looks at how long people with advanced pancreatic cancer live and how their quality of life is affected while being treated at different hospitals in the Nordic region.

  Recruiting Umeå University · Umeå · NCT05356039

• Evaluating tumor cell characteristics in breast cancer patients

  This study is testing if tracking certain tumor cells in breast cancer patients can help predict how well they respond to treatment after chemotherapy and surgery.

  Recruiting Hunan Cancer Hospital · Changsha, Hunan · NCT05326295

• Using capecitabine to reduce breast cancer recurrence in high-risk patients

  This study is testing if the drug capecitabine can help reduce the chances of breast cancer coming back in women aged 18-70 who are at high risk after surgery.

  Recruiting Phase 3 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hanzhou, Zhejiang · NCT05212454

• Examining brain changes in colorectal cancer patients undergoing chemotherapy

  This study is trying to see how chemotherapy affects thinking and memory in people with colorectal cancer.

  Recruiting Parkview Health · Fort Wayne, Indiana · NCT05014399

• Combination of chemotherapy and immunotherapy for advanced esophagogastric junction cancer

  This study is testing if combining a new immune therapy with chemotherapy can help people with advanced esophagogastric junction cancer have smaller tumors that are easier to remove and improve their chances of living longer.

  Recruiting Phase 2 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT04989985

• Neoadjuvant treatments for esophageal cancer

  This study is testing different combinations of treatments for people with esophageal cancer to see if they can improve outcomes compared to just having surgery.

  Recruiting Phase 3 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing · NCT04821843

• Chemoradiotherapy for esophageal and esophagogastric junction cancer

  This study is testing a new combination of chemotherapy, radiation, and immune therapies to see if it helps people with advanced esophageal or esophagogastric junction cancer live longer and feel better.

  Recruiting at 5 sites Phase 3 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Anyang, Henan and 4 other locations · NCT04821778

• Using topotecan and melphalan to treat retinoblastoma

  This study is testing if giving the chemotherapy drugs topotecan and melphalan directly into the eye can effectively treat retinoblastoma while saving the eye from removal.

  Recruiting Phase 3 Sun Yat-sen University · Guangzhou, Guangdong · NCT04799002

• Neoadjuvant chemotherapy for gastric cancer using oxaliplatin and S-1

  This study is testing if a combination of two drugs, oxaliplatin and S-1, can help people with advanced stomach cancer by shrinking their tumors before surgery.

  Recruiting Phase 3 Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT04483076

• Combining Gemcitabine and Celecoxib for Pancreatic Cancer Treatment

  This study is testing if adding celecoxib to gemcitabine can help people who have had surgery for pancreatic cancer live longer and stay cancer-free.

  Recruiting Phase 2 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT03498326

• Using HIPEC for advanced ovarian cancer treatment during surgery

  This study is testing whether a special type of heated chemotherapy given during surgery can help people with advanced ovarian cancer live better and longer after their treatment.

  Recruiting Phase 2 Instituto Nacional de Cancerologia de Mexico · Mexico City · NCT03275194

Related topics

Quick answers

How many Chemotherapy Effect clinical trials are recruiting right now?

39, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in China (21 trials), United States (3 trials), Netherlands (2 trials), Sweden (2 trials), Norway (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 14, Phase 2: 7, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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