The relationship between oral bacteria and tooth decay in children with HIV
Official title: Oral Microbiomes and Dental Caries in a Human Immunodeficiency Virus Infected Population
Funded at Clemson University · NIH-10424444 · Data updated 2026-11-12
This study looks at how the germs in the mouths of children with HIV might affect their risk of getting cavities, and it aims to find ways to help keep their teeth healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project start | September 11, 2018 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $206,627 |
| NIH project number | 5R01DE028154-05 |
| Project ID | NIH-10424444 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are infected with HIV and may be experiencing dental caries.
✕Less likely to help
Patients who are not infected with HIV or who are outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research investigates how the oral microbiome, which consists of various bacteria and fungi, affects dental caries (tooth decay) in children infected with HIV. It focuses on understanding the differences in the composition of oral bacteria between healthy children and those with HIV, particularly those undergoing treatment. By analyzing dental plaque and gene expression, the study aims to identify specific microbial changes that may contribute to increased tooth decay in this vulnerable population. The findings could lead to improved prevention and treatment strategies for maintaining oral health in HIV-infected children.
Why it matters
Potential benefit: If successful, this research could lead to better oral health outcomes and targeted prevention strategies for children living with HIV.
How similar studies have gone: Previous studies have shown significant changes in the oral microbiome related to health conditions, indicating that this research approach has potential for success.
Where this research is happening
-
Clemson University
Clemson, United States Active
Researchers
- Principal investigator: Richards, Vincent — Clemson University
- Study coordinator: Richards, Vincent
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.