Condition

Chronic Pancreatitis clinical trials and research

• 33Clinical trials
• 37NIH research projects
• 2New in 30 days
• 11Countries

Newest Chronic Pancreatitis clinical trials

All recruiting trials (33)

• CBT-248 safety in healthy adults for chronic pancreatitis support

  This early study tests CBT-248 in healthy adults to see if it is safe, how it behaves in the body, and whether meals affect its levels.

  Recruiting Phase 1 Cibus Therapeutics, Inc. · Melbourne, Victoria · NCT07905053

• Blood protein biomarkers to help diagnose pancreatic cancer in adults

  This study tests whether blood protein biomarkers can help detect pancreatic ductal adenocarcinoma and tell it apart from chronic pancreatitis and mucinous pancreatic lesions, and whether combining markers with CA 19-9 improves accuracy.

  Recruiting Grigore T. Popa University of Medicine and Pharmacy · Iași · NCT07875582

• Relieving a blocked pancreatic duct in chronic pancreatitis

  This pilot study tests whether clearing a blocked pancreatic duct with endoscopy can help people with chronic pancreatitis who have mild symptoms.

  Recruiting Phase 1 Mayo Clinic · Rochester, Minnesota · NCT07810309

• Understanding brain changes in chronic pancreatitis pain

  This study tests whether central nervous system changes and neuropsychological factors help explain persistent pain in adults with chronic pancreatitis.

  Recruiting Asian Institute of Gastroenterology, India · Hyderabad, Telangana · NCT07707609

• EUS-guided pancreaticobiliary procedures with the RIVOS access device

  This study tests how the RIVOS EUS access device performs during interventional procedures for pancreatic and bile duct problems in adults.

  Recruiting Orlando Health, Inc. · Orlando, Florida · NCT07696572

• Odesa Criteria 2026: tests for autoimmune pancreatitis diagnosis

  This study checks if the OC26 scoring system can accurately diagnose autoimmune pancreatitis in adults who may have AIP or related pancreatic diseases.

  Recruiting at 2 sites Military Medical Clinical Center of the Southern Region, Ukraine · Odesa and 1 other locations · NCT07536841

• Soy-tomato juice for people with recurrent acute or chronic pancreatitis

  This will try giving daily soy-tomato juice to people with recurrent acute or chronic pancreatitis to see if they can tolerate it and whether it reduces inflammation and symptoms.

  Recruiting Phase 1/2 Ohio State University · Columbus, Ohio · NCT07447687

• AI-guided decision support for managing pancreatic conditions

  This project will test an AI tool that reads contrast-enhanced CT scans to help doctors decide whether people with suspected pancreatic disease need surgery, close monitoring, or routine follow-up.

  Recruiting Changhai Hospital · Shanghai · NCT07439757

• Blood test to find mild-to-moderate pancreatic enzyme insufficiency and guide enzyme treatment for people with pancreatitis

  This project will use the Malabsorption Blood Test to find adults with recurrent acute or chronic pancreatitis who have mild-to-moderate exocrine pancreatic insufficiency and see if pancreatic enzyme replacement for responsive patients improves quality of life.

  Recruiting Phase 4 University of Pittsburgh · Baltimore, Maryland and 1 other locations · NCT07418593

• Scrambler therapy for chronic pancreatitis pain

  We will test whether Scrambler Therapy can reduce persistent abdominal pain in adults with chronic pancreatitis who haven't found relief from standard treatments.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07174609

• Robot-assisted versus open lateral pancreaticojejunostomy for symptomatic chronic pancreatitis

  This trial will test whether robot-assisted or open lateral pancreaticojejunostomy leads to better early recovery for adults with chronic pancreatitis and a dilated main pancreatic duct.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT07109180

• Using metformin to treat diabetes after chronic pancreatitis

  This study is testing if metformin can help people with diabetes that developed after chronic pancreatitis manage their blood sugar better and stay safe from side effects.

  Recruiting Phase 4 Changhai Hospital · Shanghai, Shanghai Municipality · NCT06937294

• Observing the effects and progression of chronic pancreatitis

  This study is trying to gather detailed information from people with chronic pancreatitis to see how the condition affects them and improve their diagnosis and treatment.

  Recruiting Changhai Hospital · Shanghai, Shanghai Municipality · NCT06925204

• Translation and validation of a pain assessment tool for chronic pancreatitis in Chinese patients

  This study is testing a new Chinese pain assessment tool for people with chronic pancreatitis to see if it accurately measures their pain.

  Recruiting Changhai Hospital · Shanghai, Shanghai Municipality · NCT06917716

• Comparing two types of stents for treating bile duct issues from chronic pancreatitis

  This study is testing whether a plastic stent works just as well as a metal stent for treating bile duct problems caused by chronic pancreatitis.

  Recruiting Changhai Hospital · Shanghai, Shanghai Municipality · NCT06655051

• Collecting samples to identify gene mutations in children at risk for pancreatic cancer

  This study is trying to find out if certain gene changes in children with pancreatitis can help us understand their risk of getting pancreatic cancer later on.

  Recruiting at 26 sites M.D. Anderson Cancer Center · Los Angeles, California and 25 other locations · NCT06651580

• Internet program for managing pain in pancreatitis patients

  This study is testing an online program that helps people with pancreatitis manage their pain better and improve their quality of life.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT06386224

• Identifying biomarkers for pain response in chronic pancreatitis patients undergoing endoscopic therapy

  This study is testing if certain biological markers can help predict how well people with chronic pancreatitis will respond to endoscopic therapy for pain relief.

  Recruiting NYU Langone Health · New York, New York · NCT06267365

• Infusion of stem cells to reduce pain from chronic pancreatitis

  This study is testing whether infusing stem cells can help reduce pain for people suffering from chronic pancreatitis.

  Recruiting Early Phase 1 Medical University of South Carolina · Charleston, South Carolina · NCT06205342

• EUS-guided celiac plexus block for chronic pancreatitis pain relief

  This study is testing whether a special injection to block pain in the belly can help people with chronic pancreatitis feel less pain.

  Recruiting Orlando Health, Inc. · Orlando, Florida · NCT06178315

• Cell therapy using stem cells to relieve pain from chronic pancreatitis

  This study is testing if using stem cells from veterans' bone marrow can help relieve pain from chronic pancreatitis and improve how their pancreas works.

  Recruiting Phase 1 VA Office of Research and Development · Charleston, South Carolina · NCT05925036

• Using simvastatin to improve outcomes in patients with chronic pancreatitis

  This study is testing if simvastatin can help improve the quality of life and slow down disease progression for adults with chronic pancreatitis and recurrent acute pancreatitis.

  Recruiting at 5 sites Early Phase 1 Cedars-Sinai Medical Center · Los Angeles, California and 4 other locations · NCT05771675

• National registry for chronic pancreatitis in Italy

  This study is collecting information from patients with chronic pancreatitis in Italy to better understand how the disease is diagnosed and managed over time.

  Recruiting Associazione Italiana per lo Studio del Pancreas · Milan · NCT05733130

• Using sensory testing to predict pain treatment response in chronic pancreatitis

  This study is testing if a special sensory test can help predict how well different pain treatments will work for people with chronic pancreatitis.

  Recruiting at 3 sites University of Pittsburgh · Indianapolis, Indiana and 2 other locations · NCT04996628

• Registry analyzing outcomes of therapeutic endoscopic ultrasound procedures

  This study looks at how well therapeutic endoscopic ultrasound works for people with gastrointestinal issues and what factors might affect the results.

  Recruiting IRCCS San Raffaele · Milan · NCT04813055

• Using AI for early screening of pancreatic cancer

  This study is testing if using artificial intelligence can help find pancreatic cancer earlier in people who are at high risk, like those with new diabetes or family history of the disease.

  Recruiting Changhai Hospital · Shanghai · NCT04743479

• Pain management for chronic pancreatitis using endoscopic ultrasound techniques

  This study is testing a new way to manage pain for people with chronic pancreatitis by using a special ultrasound technique to block pain signals.

  Recruiting Indiana University · Indianapolis, Indiana · NCT04403074

• Evaluating the progression of pancreatitis from acute to chronic stages

  This study is trying to see how acute pancreatitis can turn into chronic pancreatitis over time by following patients with different stages of the condition and using advanced imaging and tests.

  Recruiting at 3 sites Copenhagen University Hospital, Hvidovre · Hvidovre, Capital Region Denmark and 2 other locations · NCT03853447

• Identifying blood markers for early pancreatic cancer

  This study is trying to find specific blood markers that can help detect early pancreatic cancer in people who are at higher risk.

  Recruiting University of Nebraska · Omaha, Nebraska · NCT03568630

• Using sensory testing to predict treatment response in chronic pancreatitis

  This study is testing if a special pain sensitivity test can help predict how well people with chronic pancreatitis will respond to different treatments.

  Recruiting at 2 sites University of Pittsburgh · Baltimore, Maryland and 1 other locations · NCT03434392

• Graft function after autologous islet transplantation

  We will see if measuring inflammatory markers in blood before and after total pancreatectomy with islet autotransplantation helps explain how well transplanted islet cells work in adults with chronic pancreatitis.

  Recruiting Baylor Research Institute · Dallas, Texas · NCT03097185

• Registry for patients with pancreatic diseases

  This study is creating a registry to collect information from patients with pancreatic diseases to help researchers understand what causes these conditions and how to prevent them.

  Recruiting at 2 sites Icahn School of Medicine at Mount Sinai · New York, New York and 1 other locations · NCT02775461

• Collecting medical information and tissue samples from patients with pancreatic disorders

  This study is collecting medical information and samples from people with pancreatic cancer or other pancreatic disorders to help find better ways to detect and treat these diseases.

  Recruiting at 3 sites Mayo Clinic · Phoenix, Arizona and 2 other locations · NCT00830557

NIH-funded research (37)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Chronic Pancreatitis and Related Conditions Data Center Supports Multi-Center Research

  A national effort to organize and share clinical data and biosamples from people with chronic pancreatitis, pancreatogenic diabetes, and pancreatic cancer to speed biomarker discovery and new treatments.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11592146

• Malabsorption Blood Test for Exocrine Pancreatic Function in Chronic Pancreatitis

  A blood test (MBT) will help identify people with mild to moderate pancreatic fat malabsorption and show how well enzyme therapy improves their quality of life.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11415052

• Chronic Pancreatitis Clinical Research Cohort and Biorepository

  A long-term study at UF/Advent Health following adults with acute, relapsing, and chronic pancreatitis to build a detailed group with biospecimens and data for better diagnosis and personalized care.

  NIH research University of Florida · Gainesville, United States · NIH-11408761

• Cedars-Sinai Center leads research on chronic pancreatitis and pancreatic cancer

  A Cedars-Sinai research center is renewing its program to study chronic pancreatitis, diabetes-related pancreatic disease, and pancreatic cancer so doctors can better understand and treat these conditions.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11401819

• UPMC Center for Pancreatitis and Diabetes research program

  A specialized center at the University of Pittsburgh is advancing clinical and biological studies of chronic pancreatitis, recurrent acute pancreatitis, and diabetes to improve understanding and care.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11401437

• Chronic Pancreatitis Research Network to Understand Symptoms and Find Treatments

  This project advances studies of chronic pancreatitis to understand why some people progress and to test new ideas that could diagnose or slow the disease.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11400539

• Chronic Pancreatitis Clinical Research Consortium at Stanford

  A Stanford-based effort is renewing a patient-centered program to study chronic pancreatitis and recurrent acute pancreatitis, with ongoing recruitment of both adult and pediatric participants.

  NIH research Stanford University · Stanford, United States · NIH-11400526

• Pediatric pancreatitis: finding early clues to predict progression and guide therapies

  This project looks at why some children with acute recurrent pancreatitis develop chronic pancreatitis and how to tailor future treatments.

  NIH research University of Iowa · Iowa City, United States · NIH-11400490

• OKPRC: Improving diagnosis and care for chronic pancreatitis

  A program from Ohio State University aims to improve how chronic pancreatitis is diagnosed and treated, through biomarker validation, nutrition research, and clinical trials.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11400442

• Chronic Pancreatitis Data Coordinating Center for Coordinated Research

  A nationwide group is coordinating data and biospecimens to better understand chronic pancreatitis and related conditions to improve care.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11400335

• Internet-delivered pain self-management for pancreatitis

  A digital cognitive-behavioral therapy program helps people with recurrent acute or chronic pancreatitis reduce pain and how much it interferes with daily life.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11398838

• Safety and pain relief with stem cells for chronic pancreatitis

  Aims to see if stem cell therapy can safely lessen chronic pancreas pain and improve quality of life for people with chronic pancreatitis.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11380938

• Pancreatic enzyme use to reduce pancreatitis episodes in children

  A study tests whether pancreatic enzyme replacement therapy can cut episodes of pancreatitis and improve quality of life for children with pancreatic-relevant ARP or CP.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11346366

• PKD1 protein's role in turning acute pancreatitis into chronic pancreatitis

  Seeing if blocking a protein called PKD1 can stop acute pancreatitis from turning into chronic pancreatitis.

  NIH research Mayo Clinic Jacksonville · Jacksonville, United States · NIH-11321526

• Understanding how a brain-like immune switch (TREM2) affects chronic pancreatitis

  A patient-friendly look at how a specific immune receptor called TREM2 might control inflammation and tissue damage in chronic pancreatitis, with potential paths toward better treatment.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11269401

• Soy-and-tomato diet to lower inflammation in chronic pancreatitis

  This project gives people with chronic pancreatitis a soy-and-tomato drink to lower inflammation and help improve nutrition and symptoms.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11260254

• Indiana University Clinical Center for Chronic Pancreatitis

  This program follows people with chronic pancreatitis and at-risk children and adults to find better biomarkers and try a new drug that may slow or reverse pancreatic scarring.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11219345

• Understanding what causes chronic pancreatitis in children to guide new treatments

  This project follows children with repeated or chronic pancreatitis to find early signs and risks that could lead to better treatments.

  NIH research University of Iowa · Iowa City, United States · NIH-11219273

• UPMC Center for Chronic Pancreatitis and Diabetes

  This program follows people with chronic pancreatitis and related diabetes to learn more about causes, complications, and treatments.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11219246

• Stanford Chronic Pancreatitis Clinical Center

  This project follows adults and children with recurrent acute or chronic pancreatitis to collect medical information and biological samples to find immune-related markers tied to symptoms and outcomes.

  NIH research Stanford University · Stanford, United States · NIH-11218842

• Cedars-Sinai Chronic Pancreatitis Clinical Research Consortium

  This program follows people with chronic pancreatitis, pancreatitis-related diabetes, and pancreatic cancer to learn about causes, early signs, and better treatments.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11216446

• Network coordinating care and work on chronic pancreatitis, pancreatitis-related diabetes, and pancreatic cancer

  This program brings together hospitals to collect medical information and samples from people with chronic pancreatitis, pancreatitis-related diabetes, and pancreatic cancer to speed better tests and treatments.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11212226

• Mesenchymal stem cell therapy for chronic pancreatitis pain

  Infusions of mesenchymal stem cells aim to reduce long-term pancreas inflammation and abdominal pain for people with chronic pancreatitis.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11179488

• Online pain self-management for pancreatitis

  An online cognitive-behavioral therapy program to help people with recurrent acute or chronic pancreatitis reduce pain and its effects on daily life.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11164784

• Understanding Pain in Chronic Pancreatitis with P-QST

  This research aims to find a better way to predict which patients with chronic pancreatitis will get relief from their pain after treatment.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11126630

• Using stem cells to treat chronic pancreatitis and its pain

  This study is looking at whether mesenchymal stem cells can help people with chronic pancreatitis by reducing pain and inflammation, and if you join, you might receive these stem cell infusions to see if they can improve your comfort and overall well-being.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11066700

• A dietary intervention to reduce inflammation in chronic pancreatitis

  This study is looking at how drinking soy-tomato juice might help reduce inflammation and improve health for people with chronic pancreatitis, and we're inviting participants to try it out and see how it affects their overall well-being.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11049683

• Investigating how Protein Kinase D1 influences the transition from acute to chronic pancreatitis

  This study is looking at how a protein called Protein Kinase D1 might influence the change from acute pancreatitis to a long-lasting condition, with the goal of finding new treatments that could help people with this illness.

  NIH research Mayo Clinic Jacksonville · Jacksonville, United States · NIH-11046577

• New cell therapy for managing pain from chronic pancreatitis

  This study is looking at a new treatment using special cells to help manage the severe abdominal pain caused by chronic pancreatitis, aiming to offer a safer option than opioids for veterans and others dealing with this tough condition.

  NIH research Ralph H Johnson VA Medical Center · Charleston, United States · NIH-11044062

• Understanding how certain genetic variants lead to chronic pancreatitis

  This study is looking at how certain gene changes might make some people more likely to develop chronic pancreatitis, and it aims to find ways to help fix the problems caused by these gene changes to prevent the disease from getting worse.

  NIH research Washington University · Saint Louis, United States · NIH-11000276

• Online program to help manage pain in chronic pancreatitis patients

  This study is testing an online therapy program to help people with chronic pancreatitis manage their pain and improve their mood and daily life, and it's looking for participants who want to see if this approach works well in real life.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-10916518

• Testing a vitamin D analogue for improving quality of life in chronic pancreatitis patients

  This study is looking at whether a vitamin D-like treatment called paricalcitol can help improve the quality of life for people with chronic pancreatitis by reducing pain and boosting overall health, and it’s designed for those who are dealing with this condition.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10894739

• Investigating the links between chronic pancreatitis, diabetes, and pancreatic cancer

  This study is looking at how chronic pancreatitis, diabetes, and pancreatic cancer are related, and it's for patients who want to help us learn more about these conditions to improve care and outcomes for everyone.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-10884517

• Testing pain responses in patients with chronic pancreatitis

  This study is looking at a special test that helps doctors figure out which people with chronic pancreatitis are likely to find relief from their pain treatments, so they can create more tailored plans to help manage their discomfort.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10877786

• Investigating the safety and effectiveness of lacosamide for pain relief in chronic pancreatitis patients

  This study is looking for people with chronic pancreatitis to see if a medication called lacosamide can help manage their pain better while using fewer opioids, and it will check how well they tolerate the treatment.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-10828846

• Identifying pain response predictors for endoscopic treatment in chronic pancreatitis

  This study is looking to find out which patients with chronic pancreatitis are likely to benefit from special treatments to relieve their pain, using some cool techniques to understand both their physical and emotional experiences, so that doctors can provide more personalized care and help reduce the need for pain med

  NIH research New York University School of Medicine · New York, United States · NIH-10794609

• Investigating a treatment for alcoholic chronic pancreatitis

  This study is looking at how a drug called AMPKa agonist might help people with alcoholic chronic pancreatitis by reducing the damage caused by long-term alcohol use on the pancreas and finding new ways to improve their health.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-10649275

Related topics

Quick answers

How many Chronic Pancreatitis clinical trials are recruiting right now?

33, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in United States (19 trials), China (6 trials), Australia (2 trials), Italy (2 trials), Netherlands (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Early Phase 1: 2, Phase 4: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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