Testing a vitamin D analogue for improving quality of life in chronic pancreatitis patients
Official title: A Pilot Clinical Trial of Paricalcitol for Chronic Pancreatitis
Funded at Cedars-Sinai Medical Center · NIH-10894739 · Data updated 2026-11-12
This study is looking at whether a vitamin D-like treatment called paricalcitol can help improve the quality of life for people with chronic pancreatitis by reducing pain and boosting overall health, and it’s designed for those who are dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 15, 2022 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $318,038 |
| NIH project number | 5R01DK132631-03 |
| Project ID | NIH-10894739 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic pancreatitis who experience significant abdominal pain and related health issues.
✕Less likely to help
Patients who do not have chronic pancreatitis or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the effects of paricalcitol, a potent vitamin D analogue, on the health-related quality of life (HRQoL) of patients suffering from chronic pancreatitis. The trial aims to assess whether this treatment can alleviate pain and improve overall health outcomes by measuring patient-reported symptoms and analyzing imaging and liquid biomarkers. If successful, this pilot study could pave the way for larger trials focused on the efficacy of paricalcitol in managing chronic pancreatitis. The study employs a randomized, double-blind, placebo-controlled design to ensure reliable results.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management and quality of life for patients with chronic pancreatitis.
How similar studies have gone: There is a substantial body of preclinical evidence suggesting that vitamin D analogues have beneficial effects on pancreatitis, indicating potential for success in this clinical trial.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Pandol, Stephen J. — Cedars-Sinai Medical Center
- Study coordinator: Pandol, Stephen J.
Related research
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Chronic Pancreatitis and Related Conditions Data Center Supports Multi-Center Research
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Malabsorption Blood Test for Exocrine Pancreatic Function in Chronic Pancreatitis
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Chronic Pancreatitis Clinical Research Cohort and Biorepository
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Cedars-Sinai Center leads research on chronic pancreatitis and pancreatic cancer
A Cedars-Sinai research center is renewing its program to study chronic pancreatitis, diabetes-related pancreatic disease, and pancreatic cancer so doctors can better understand and treat these conditions.
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UPMC Center for Pancreatitis and Diabetes research program
A specialized center at the University of Pittsburgh is advancing clinical and biological studies of chronic pancreatitis, recurrent acute pancreatitis, and diabetes to improve understanding and care.
-
Chronic Pancreatitis Research Network to Understand Symptoms and Find Treatments
This project advances studies of chronic pancreatitis to understand why some people progress and to test new ideas that could diagnose or slow the disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.