Testing a vitamin D analogue for improving quality of life in chronic pancreatitis patients
A Pilot Clinical Trial of Paricalcitol for Chronic Pancreatitis
This study is looking at whether a vitamin D-like treatment called paricalcitol can help improve the quality of life for people with chronic pancreatitis by reducing pain and boosting overall health, and it’s designed for those who are dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10894739 on NIH RePORTER |
What this research studies
This research investigates the effects of paricalcitol, a potent vitamin D analogue, on the health-related quality of life (HRQoL) of patients suffering from chronic pancreatitis. The trial aims to assess whether this treatment can alleviate pain and improve overall health outcomes by measuring patient-reported symptoms and analyzing imaging and liquid biomarkers. If successful, this pilot study could pave the way for larger trials focused on the efficacy of paricalcitol in managing chronic pancreatitis. The study employs a randomized, double-blind, placebo-controlled design to ensure reliable results.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic pancreatitis who experience significant abdominal pain and related health issues.
Not a fit: Patients who do not have chronic pancreatitis or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management and quality of life for patients with chronic pancreatitis.
How similar studies have performed: There is a substantial body of preclinical evidence suggesting that vitamin D analogues have beneficial effects on pancreatitis, indicating potential for success in this clinical trial.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Pandol, Stephen J. — Cedars-Sinai Medical Center
- Study coordinator: Pandol, Stephen J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.