Evaluating the progression of pancreatitis from acute to chronic stages

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the development of chronic pancreatitis by utilizing advanced imaging techniques and biochemical markers to monitor inflammation, fibrosis, and oxidative stress. Participants include individuals experiencing their first episode of acute pancreatitis, recurrent acute pancreatitis, or early chronic pancreatitis, as well as those with end-stage chronic pancreatitis. The study will follow these patients for 15 years, employing methods such as MRI, contrast-enhanced endoscopic ultrasound, and various assessments of pancreatic function and pain processing. Additionally, a biobank will be established to analyze potential biomarkers related to disease progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with CP (N=50) of any aetiology except gallstone induced CP: CP will be diagnosed based on MANNHEIM criteria .
* Cohort 2: Patients with their first attack of AP of any aetiology except gallstone induced AP (N=50). The revised Atlanta criteria for acute pancreatitis will be used as diagnostic criteria.
* Cohort 3: Patients with RAP (N=50) except gallstone induced RAP. RAP is defined as two or more cases of AP as diagnosed by the revised Atlanta Criteria.

Exclusion Criteria:

Where it's running

• Gastrounit, Copenhagen University Hospital Hvidovre
  Hvidovre, Capital Region Denmark, Denmark Recruiting
• Department of Gastroenterology & Hepatology, Aalborg University Hospital
  Aalborg, Denmark Recruiting
• Abdominal Centre, Bispebjerg University Hospital
  Copenhagen, Denmark Recruiting

Study contacts

• Study coordinator: Srdan Novovic, PhD
• Email: srdan.novovic@regionh.dk
• Phone: 38623862

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.