Evaluating the progression of pancreatitis from acute to chronic stages
Characterization of Fibro-inflammation During Progression From Acute to Chronic Pancreatitis
This study is trying to see how acute pancreatitis can turn into chronic pancreatitis over time by following patients with different stages of the condition and using advanced imaging and tests.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Copenhagen University Hospital, Hvidovre Academic / other |
| Locations | 3 sites (Hvidovre, Capital Region Denmark and 2 other locations) |
| Trial ID | NCT03853447 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the development of chronic pancreatitis by utilizing advanced imaging techniques and biochemical markers to monitor inflammation, fibrosis, and oxidative stress. Participants include individuals experiencing their first episode of acute pancreatitis, recurrent acute pancreatitis, or early chronic pancreatitis, as well as those with end-stage chronic pancreatitis. The study will follow these patients for 15 years, employing methods such as MRI, contrast-enhanced endoscopic ultrasound, and various assessments of pancreatic function and pain processing. Additionally, a biobank will be established to analyze potential biomarkers related to disease progression.
Who should consider this trial
Good fit: Ideal candidates include patients with their first episode of acute pancreatitis, recurrent acute pancreatitis, early chronic pancreatitis, or end-stage chronic pancreatitis.
Not a fit: Patients with gallstone-induced pancreatitis will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection and prevention strategies for chronic pancreatitis, improving patient outcomes.
How similar studies have performed: While there have been studies on pancreatitis, this specific approach focusing on the transition from acute to chronic pancreatitis using advanced imaging and biomarkers is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with CP (N=50) of any aetiology except gallstone induced CP: CP will be diagnosed based on MANNHEIM criteria . * Cohort 2: Patients with their first attack of AP of any aetiology except gallstone induced AP (N=50). The revised Atlanta criteria for acute pancreatitis will be used as diagnostic criteria. * Cohort 3: Patients with RAP (N=50) except gallstone induced RAP. RAP is defined as two or more cases of AP as diagnosed by the revised Atlanta Criteria. Exclusion Criteria:
Where this trial is running
Hvidovre, Capital Region Denmark and 2 other locations
- Gastrounit, Copenhagen University Hospital Hvidovre — Hvidovre, Capital Region Denmark, Denmark (Recruiting)
- Department of Gastroenterology & Hepatology, Aalborg University Hospital — Aalborg, Denmark (Recruiting)
- Abdominal Centre, Bispebjerg University Hospital — Copenhagen, Denmark (Recruiting)
Study contacts
- Study coordinator: Srdan Novovic, PhD
- Email: srdan.novovic@regionh.dk
- Phone: 38623862
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.