Investigating how Protein Kinase D1 influences the transition from acute to chronic pancreatitis
Protein Kinase D1 as a switch from acute to chronic pancreatitis
This study is looking at how a protein called Protein Kinase D1 might influence the change from acute pancreatitis to a long-lasting condition, with the goal of finding new treatments that could help people with this illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11046577 on NIH RePORTER |
What this research studies
This research explores the role of Protein Kinase D1 in the progression of acute pancreatitis to a chronic condition. It aims to understand how this protein affects acinar cells in the pancreas, potentially leading to chronic inflammation and fibrosis. The study will utilize animal models to observe the effects of PKD1 on the development and resolution of chronic pancreatitis. By identifying the molecular mechanisms involved, the research seeks to develop targeted therapies that could inhibit PKD1 and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced acute pancreatitis and are at risk of developing chronic pancreatitis.
Not a fit: Patients with chronic pancreatitis that has already progressed significantly may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent acute pancreatitis from becoming chronic, reducing the risk of complications such as pancreatic cancer.
How similar studies have performed: While the specific approach of targeting Protein Kinase D1 is novel, similar research has shown promise in understanding the mechanisms of pancreatitis progression.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Storz, Peter — Mayo Clinic Jacksonville
- Study coordinator: Storz, Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.