Investigating how Protein Kinase D1 influences the transition from acute to chronic pancreatitis
Official title: Protein Kinase D1 as a switch from acute to chronic pancreatitis
Funded at Mayo Clinic Jacksonville · NIH-11046577 · Data updated 2026-11-12
This study is looking at how a protein called Protein Kinase D1 might influence the change from acute pancreatitis to a long-lasting condition, with the goal of finding new treatments that could help people with this illness.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $340,388 |
| NIH project number | 5R01DK139604-02 |
| Project ID | NIH-11046577 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced acute pancreatitis and are at risk of developing chronic pancreatitis.
✕Less likely to help
Patients with chronic pancreatitis that has already progressed significantly may not benefit from this research.
What this research studies
This research explores the role of Protein Kinase D1 in the progression of acute pancreatitis to a chronic condition. It aims to understand how this protein affects acinar cells in the pancreas, potentially leading to chronic inflammation and fibrosis. The study will utilize animal models to observe the effects of PKD1 on the development and resolution of chronic pancreatitis. By identifying the molecular mechanisms involved, the research seeks to develop targeted therapies that could inhibit PKD1 and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent acute pancreatitis from becoming chronic, reducing the risk of complications such as pancreatic cancer.
How similar studies have gone: While the specific approach of targeting Protein Kinase D1 is novel, similar research has shown promise in understanding the mechanisms of pancreatitis progression.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Storz, Peter — Mayo Clinic Jacksonville
- Study coordinator: Storz, Peter
Related research
Other NIH-funded projects on the same topics.
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Chronic Pancreatitis and Related Conditions Data Center Supports Multi-Center Research
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-
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Chronic Pancreatitis Clinical Research Cohort and Biorepository
A long-term study at UF/Advent Health following adults with acute, relapsing, and chronic pancreatitis to build a detailed group with biospecimens and data for better diagnosis and personalized care.
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Cedars-Sinai Center leads research on chronic pancreatitis and pancreatic cancer
A Cedars-Sinai research center is renewing its program to study chronic pancreatitis, diabetes-related pancreatic disease, and pancreatic cancer so doctors can better understand and treat these conditions.
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UPMC Center for Pancreatitis and Diabetes research program
A specialized center at the University of Pittsburgh is advancing clinical and biological studies of chronic pancreatitis, recurrent acute pancreatitis, and diabetes to improve understanding and care.
-
Chronic Pancreatitis Research Network to Understand Symptoms and Find Treatments
This project advances studies of chronic pancreatitis to understand why some people progress and to test new ideas that could diagnose or slow the disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.