Investigating the safety and effectiveness of lacosamide for pain relief in chronic pancreatitis patients
Official title: Safety, tolerability, and dose limiting toxicity of lacosamide in patients with painful chronic pancreatitis
Funded at Indiana University Indianapolis · NIH-10828846 · Data updated 2026-11-12
This study is looking for people with chronic pancreatitis to see if a medication called lacosamide can help manage their pain better while using fewer opioids, and it will check how well they tolerate the treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | April 15, 2022 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $304,462 |
| NIH project number | 5R01DK132709-03 |
| Project ID | NIH-10828846 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic pancreatitis who experience significant abdominal pain and are currently using opioids for pain management.
✕Less likely to help
Patients who do not have chronic pancreatitis or those who are not experiencing significant abdominal pain may not benefit from this research.
What this research studies
This research focuses on patients suffering from chronic pancreatitis, a condition characterized by severe abdominal pain. It aims to evaluate the safety and tolerability of lacosamide, a medication that may help manage pain while reducing reliance on opioids. The study will involve administering lacosamide alongside opioid therapy and monitoring for any dose-limiting toxicities. By using a specific trial design, researchers hope to determine the optimal dosage that minimizes side effects while effectively controlling pain.
Why it matters
Potential benefit: If successful, this research could provide a new pain management option for patients with chronic pancreatitis, potentially reducing their dependence on opioids.
How similar studies have gone: Previous studies have shown that lacosamide can effectively reduce pain in neuropathic pain conditions, but its use in chronic pancreatitis is novel and untested.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Fogel, Evan L — Indiana University Indianapolis
- Study coordinator: Fogel, Evan L
Related research
Other NIH-funded projects on the same topics.
-
Chronic Pancreatitis and Related Conditions Data Center Supports Multi-Center Research
A national effort to organize and share clinical data and biosamples from people with chronic pancreatitis, pancreatogenic diabetes, and pancreatic cancer to speed biomarker discovery and new treatments.
-
Malabsorption Blood Test for Exocrine Pancreatic Function in Chronic Pancreatitis
A blood test (MBT) will help identify people with mild to moderate pancreatic fat malabsorption and show how well enzyme therapy improves their quality of life.
-
Chronic Pancreatitis Clinical Research Cohort and Biorepository
A long-term study at UF/Advent Health following adults with acute, relapsing, and chronic pancreatitis to build a detailed group with biospecimens and data for better diagnosis and personalized care.
-
Cedars-Sinai Center leads research on chronic pancreatitis and pancreatic cancer
A Cedars-Sinai research center is renewing its program to study chronic pancreatitis, diabetes-related pancreatic disease, and pancreatic cancer so doctors can better understand and treat these conditions.
-
UPMC Center for Pancreatitis and Diabetes research program
A specialized center at the University of Pittsburgh is advancing clinical and biological studies of chronic pancreatitis, recurrent acute pancreatitis, and diabetes to improve understanding and care.
-
Chronic Pancreatitis Research Network to Understand Symptoms and Find Treatments
This project advances studies of chronic pancreatitis to understand why some people progress and to test new ideas that could diagnose or slow the disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.