Investigating the safety and effectiveness of lacosamide for pain relief in chronic pancreatitis patients
Safety, tolerability, and dose limiting toxicity of lacosamide in patients with painful chronic pancreatitis
This study is looking for people with chronic pancreatitis to see if a medication called lacosamide can help manage their pain better while using fewer opioids, and it will check how well they tolerate the treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10828846 on NIH RePORTER |
What this research studies
This research focuses on patients suffering from chronic pancreatitis, a condition characterized by severe abdominal pain. It aims to evaluate the safety and tolerability of lacosamide, a medication that may help manage pain while reducing reliance on opioids. The study will involve administering lacosamide alongside opioid therapy and monitoring for any dose-limiting toxicities. By using a specific trial design, researchers hope to determine the optimal dosage that minimizes side effects while effectively controlling pain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic pancreatitis who experience significant abdominal pain and are currently using opioids for pain management.
Not a fit: Patients who do not have chronic pancreatitis or those who are not experiencing significant abdominal pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new pain management option for patients with chronic pancreatitis, potentially reducing their dependence on opioids.
How similar studies have performed: Previous studies have shown that lacosamide can effectively reduce pain in neuropathic pain conditions, but its use in chronic pancreatitis is novel and untested.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Fogel, Evan L — Indiana University Indianapolis
- Study coordinator: Fogel, Evan L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.