Indiana University Clinical Center for Chronic Pancreatitis
Indiana University (IU) Clinical Center for Chronic Pancreatitis Clinical Research Network
['FUNDING_U01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11219345
This program follows people with chronic pancreatitis and at-risk children and adults to find better biomarkers and try a new drug that may slow or reverse pancreatic scarring.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11219345 on ClinicalTrials.gov |
What this research studies
I would join a long-term network that follows people with chronic pancreatitis and children at risk to track symptoms, imaging, and blood or tissue samples over time. The team will use MRI scans and new imaging criteria as possible markers of disease and collect biological samples to look for changes that predict worsening. They also plan a treatment arm testing a Galectin-3 blocker to see if it can reduce or stop the scarring in the pancreas. The work is done through the PROCEED and INSPPIRE-2 cohorts and IU network sites so you would be followed at participating clinics.
Who could benefit from this research
Good fit: People of all ages with chronic pancreatitis or children and adults at high risk who are enrolled in the PROCEED or INSPPIRE-2 cohorts or eligible for the Galectin-3 inhibitor arm are the ideal candidates.
Not a fit: People without chronic pancreatitis, those with abdominal pain from other causes, or patients with very advanced, irreversible pancreatic failure may not receive direct benefit from this work.
Why it matters
Potential benefit: If successful, this work could lead to tests that detect early disease and a drug that slows or reverses pancreatic fibrosis, easing pain and lowering complications.
How similar studies have performed: MRI biomarkers and Galectin-3 blockers have shown promise in other fibrotic diseases and early studies, but using them specifically for chronic pancreatitis is relatively new.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EASLER, JEFFREY JAMES — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: EASLER, JEFFREY JAMES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.