Using sensory testing to predict pain treatment response in chronic pancreatitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of Pancreatic Quantitative Sensory Testing (P-QST) in predicting treatment responses for abdominal pain in patients with chronic pancreatitis. By assessing patients' neurosensory profiles before they undergo invasive treatments such as endoscopic therapy or surgery, the study aims to develop a predictive model for individualized pain management. Participants will complete follow-up assessments at 3, 6, and 12 months post-treatment to evaluate their pain levels and overall treatment outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients ≥ 18 years of age with definite CP undergoing decompressive invasive treatments (endoscopic therapy or surgery) to relieve main pancreatic duct obstruction due to stones and/or stricture for management of pain.

  * Endoscopic therapy: Endoscopic Retrograde Cholangiopancreatography (ERCP) with pancreatic duct stone removal, stent placement, and/or stricture dilation, ± intraductal lithotripsy or Extracorporeal Shock Wave Lithotripsy (ESWL).
  * Surgery: drainage procedures (Frey and Puestow operations)

Exclusion Criteria:

* Patients with chronic pain from conditions other than CP
* Patients \< 18 years of age
* Patients who have had endoscopic therapy within the past 12 months
* Patients who have undergone prior pancreatic surgery
* Patients who have resective surgical procedure planned (eg. Whipple procedure, Total Pancreatectomy)
* Patients with peripheral sensory deficits
* Patients with known pregnancy at the time of study screening\*\*

  * Note: Women who become pregnant during the course of the study can no longer participate in P-QST testing.

Where it's running

• Indiana University Medical Center
  Indianapolis, Indiana, United States Recruiting
• Johns Hopkins Medical Institutions
  Baltimore, Maryland, United States Recruiting
• University of Pittsburgh Medical Center
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Anna Evans Phillips, MD, MS — University of Pittsburgh
• Study coordinator: Anna Evans Phillips, MD, MS
• Email: evansac3@upmc.edu
• Phone: 412-647-2345

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.