Using sensory testing to predict pain treatment response in chronic pancreatitis
Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis
This study is testing if a special sensory test can help predict how well different pain treatments will work for people with chronic pancreatitis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 3 sites (Indianapolis, Indiana and 2 other locations) |
| Trial ID | NCT04996628 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of Pancreatic Quantitative Sensory Testing (P-QST) in predicting treatment responses for abdominal pain in patients with chronic pancreatitis. By assessing patients' neurosensory profiles before they undergo invasive treatments such as endoscopic therapy or surgery, the study aims to develop a predictive model for individualized pain management. Participants will complete follow-up assessments at 3, 6, and 12 months post-treatment to evaluate their pain levels and overall treatment outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with chronic pancreatitis who are scheduled for invasive treatments to relieve pain.
Not a fit: Patients with chronic pain from conditions other than chronic pancreatitis or those who have had recent endoscopic therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more personalized and effective pain management strategies for patients with chronic pancreatitis.
How similar studies have performed: While the use of sensory testing in this context is relatively novel, similar approaches in pain management have shown promise in other studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients ≥ 18 years of age with definite CP undergoing decompressive invasive treatments (endoscopic therapy or surgery) to relieve main pancreatic duct obstruction due to stones and/or stricture for management of pain. * Endoscopic therapy: Endoscopic Retrograde Cholangiopancreatography (ERCP) with pancreatic duct stone removal, stent placement, and/or stricture dilation, ± intraductal lithotripsy or Extracorporeal Shock Wave Lithotripsy (ESWL). * Surgery: drainage procedures (Frey and Puestow operations) Exclusion Criteria: * Patients with chronic pain from conditions other than CP * Patients \< 18 years of age * Patients who have had endoscopic therapy within the past 12 months * Patients who have undergone prior pancreatic surgery * Patients who have resective surgical procedure planned (eg. Whipple procedure, Total Pancreatectomy) * Patients with peripheral sensory deficits * Patients with known pregnancy at the time of study screening\*\* * Note: Women who become pregnant during the course of the study can no longer participate in P-QST testing.
Where this trial is running
Indianapolis, Indiana and 2 other locations
- Indiana University Medical Center — Indianapolis, Indiana, United States (Recruiting)
- Johns Hopkins Medical Institutions — Baltimore, Maryland, United States (Recruiting)
- University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States (Recruiting)
Study contacts
- Principal investigator: Anna Evans Phillips, MD, MS — University of Pittsburgh
- Study coordinator: Anna Evans Phillips, MD, MS
- Email: evansac3@upmc.edu
- Phone: 412-647-2345
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.