Condition
Chronic Obstructive Pulmonary Disease (COPD) clinical trials and research
As of November 12, 2026, Find a Trial lists 80 Chronic Obstructive Pulmonary Disease (COPD) clinical trials that are recruiting, at sites in 52 countries (most in China (14), United States (13), United Kingdom (8)). 5 were first registered in the last 30 days. By phase: Phase 2 (7), Phase 4 (4), Phase 1/2 (3), Phase 3 (3). The most active sponsors are AstraZeneca (5), Beijing Chao Yang Hospital (3), Sanofi (2). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 80Clinical trials
- 5New in 30 days
- 52Countries
Newest Chronic Obstructive Pulmonary Disease (COPD) clinical trials
All recruiting trials (80)
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Chronic Respiratory Disease Participant Engagement
This study tests whether adults with long-term lung conditions can get comfortable with a clinical trials unit and research team before joining future trials.
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IOS-based platform to screen, diagnose, and manage COPD and asthma
This study tests an Impulse Oscillometry system to screen for and diagnose COPD and asthma and to help predict flare-ups over about a year, involving adults in China.
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Targeted NMES to improve breathing and leg/extra muscle strength in COPD
This study tests whether targeted neuromuscular electrical stimulation helps people with COPD see improvements in breathing muscle function and overall muscle strength.
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AERO-007: a inhaled LABA+LAMA combination for COPD through a nebulizer
This study tests whether a nebulized LABA+LAMA combination can improve lung function in adults with COPD.
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PBMT with a pulmonary rehab program for COPD patients
A small randomized trial tests whether adding photobiomodulation therapy before exercise in a COPD pulmonary rehab program helps improve functional capacity.
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Controlled versus standard oxygen therapy for ICU COPD with acute exacerbation
This trial tests whether keeping oxygen levels at 88-92% helps ICU patients with an acute COPD flare more than keeping levels above 94%.
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Support COPD patients with a reality-augmented coach for physical activity
This study tests a reality-augmented coach to guide and motivate adults with COPD to exercise in a real-world setting.
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RO7830698 in healthy people and COPD patients
This study tests RO7830698 to see if it is safe and how it behaves in the body for healthy individuals and people with COPD.
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Nebulized vs handheld maintenance therapy for COPD patients with limited benefit from inhalers
This trial tests whether switching to a breath-enhanced nebulizer with similar COPD meds helps people who don’t get enough relief from their current handheld inhalers.
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Blood Flow Restriction Rehab to Improve Mobility and Balance in COPD Patients
This study tests whether Blood Flow Restriction (BFR) rehabilitation can improve functional mobility and balance in people with COPD.
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Improving Care for underserved older Black patients with cardiovascular and other chronic conditions
This study tests a culturally tailored approach to patient-centered care for older African American patients with cardiovascular disease and other conditions who receive care at a community hospital.
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Health for Hungary: Long-term blood and health data collection to study aging and disease onset
This study tests whether routine blood tests plus advanced molecular analyses can help detect the early stages of non-communicable diseases in adults over 40.
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Primary Palliative Care: A Feasibility Project for Family Health Units
This feasibility trial tests a GP training program plus a structured 12-week palliative-care visit plan to see if it can be carried out in primary care for adults with advanced illness.
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PRA-216 COPD safety and biomarkers study
This study tests PRA-216 versus placebo to see if it is safe, tolerable, and biologically active in adults with moderate to severe COPD who are on standard inhaled therapy.
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EXP D-101/FXS7553 vs placebo in COPD over 52 weeks
This phase 2 study tests two doses of EXPD-101/FXS7553 to see if they help people with COPD more than a placebo over a year.
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KIT2014 in COPD: safety, tolerability, and early efficacy in moderate to severe COPD
This study tests KIT2014 versus placebo over 7 days to see if it is safe, tolerable, and shows early signs of benefit in adults with moderate to severe COPD.
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How Simeox® affects air left in the lungs in severe COPD
This pilot study tests whether a 20-minute Simeox® session can reduce the amount of air trapped in the lungs of people with severe COPD and pulmonary hyperinflation.
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Does the order of endurance and strength training in COPD rehab matter for muscle strength?
This study tests whether doing strength training before endurance training during pulmonary rehab improves muscle strength in adults with COPD.
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Breathlessness in respiratory diseases: who feels it and why
This study tests how physiology, psychology, function, and breathing patterns relate to breathlessness in people with respiratory conditions compared with healthy controls.
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Health program participation in Halsnæs for people with diabetes, COPD, or heart disease
This project tests whether a municipal health program in Halsnæs helps adults with diabetes, COPD, or cardiovascular disease participate more and stay engaged.
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Digital lifestyle platform after rehabilitation to support self-management
A digital, patient-facing platform is being tested to see if people who recently finished inpatient rehabilitation will use it and benefit from personalized lifestyle guidance at home.
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D-RSBI vs RSBI to predict weaning success in COPD patients
This study tests whether diaphragmatic rapid shallow breathing index (D-RSBI) can better predict which COPD patients on mechanical ventilation will successfully wean than the traditional RSBI.
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Dupilumab added to standard COPD care after a flare-up
This study tests whether adding dupilumab to usual COPD care after a severe flare requiring hospitalization can reduce the chance of another flare.
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Eradicating Helicobacter pylori in adults with COPD
This project will try whether getting rid of H. pylori helps adults with COPD have fewer respiratory problems or less inflammation.
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Breztri real-world safety and effectiveness in Korean patients with COPD or asthma
This post-marketing study tests Breztri in real-world Korean patients with COPD or asthma to see how safe it is and how well it works when used as usual care.
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Effects of Wood Smoke on Lung Health in Adults
This study tests how different levels of woodsmoke exposure affect lung function and inflammatory responses in healthy adults.
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Comparing Acute Medical Unit care versus usual ward care for adults with sudden medical illnesses
This research will see if care in an Acute Medical Unit (AMU) leads to better outcomes than usual general-ward care for adults admitted from the emergency department with infections, falls, or COPD flare-ups.
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Vivifrail exercise for frailty in older adults with COPD
This study will test whether the Vivifrail exercise program helps older adults (60+) with COPD and frailty improve physical function, daily activities, and quality of life.
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Somatic health screening for adults in psychiatric outpatient care
This program tries adding regular physical-health screening into psychiatric outpatient care to see if it helps detect and manage heart disease, lung disease, diabetes, and other conditions in adults with psychotic or affective disorders.
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Short-term whole-body vibration at different frequencies for people with COPD and healthy adults
This trial tests whether short sessions of whole-body vibration at different frequencies can help breathing, muscle strength, or symptoms in people with COPD and in healthy adults.
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Immune status and disease control in airway inflammatory diseases
This project will test whether specific blood immune cell patterns relate to disease control in adults with asthma, COPD, bronchiectasis, or obstructive sleep apnea by comparing them with healthy volunteers.
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Classifying treatable traits and breathlessness perception in people with COPD or asthma
This project will try to group adults with COPD or asthma by how they perceive breathlessness and link those groups to blood tests, lung tests, questionnaires, and brain scans.
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Low-load blood flow restriction training to boost arm strength in people with COPD
This trial tests whether adding low-load blood flow restriction to arm exercises helps people with moderate COPD get stronger and improve upper-extremity function compared with a sham procedure.
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Extra oxygen during the 6-minute walk for people with chronic respiratory failure or exercise-related low oxygen
This trial will test whether giving extra oxygen during a 6-minute walk helps people with chronic respiratory failure or exertional low oxygen from COPD or interstitial lung disease walk farther, breathe better, and feel easier during the test.
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Umbilical cord stem cell therapy added to standard care for Group E COPD.
This trial will try two intravenous doses of umbilical cord mesenchymal stem cells alongside usual triple inhaler therapy to see if people aged 40–75 with Group E COPD have better lung function, exercise tolerance, and symptoms over 12 months.
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IMPACT COPD Cohort — integrated Chinese–Western care and digital monitoring in China
This project will try continuous wearable and digital monitoring plus combined Chinese and Western medicine approaches for people aged 40–80 who have COPD and other chronic conditions to see if it improves care.
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Inhaled nitric oxide to improve exercise tolerance in moderate-to-severe COPD
This test tries whether breathing inhaled nitric oxide can improve exercise ability and is safe for adults 40–75 with moderate-to-severe COPD who are former smokers.
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Long-term follow-up of dupilumab treatment for COPD
This project will follow adults with uncontrolled COPD and high blood eosinophils who start dupilumab in routine care to see if it is safe and improves symptoms and quality of life over 36 months.
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REGEND007 cell therapy for COPD
This trial will test whether an intravenous infusion of REGEND007 airway basal cells is safe and can help adults aged 40–80 with COPD improve breathing and exercise capacity.
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Breathlessness patterns in adults with cancer, COPD, or heart failure using brain fMRI and immersive virtual reality
This project will try to use brain fMRI combined with immersive virtual reality to identify patterns of persistent breathlessness in adults with COPD, heart failure, or cancer and in healthy volunteers.
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COPD patients with frequent flare-ups in Moscow
We will collect medical history and treatment details to see if real-world care relates to outcomes for adults in Moscow with moderate-to-very severe COPD who have frequent flare-ups.
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9MW1911 for adults with COPD
This trial will test whether the investigational drug 9MW1911 can reduce flare-ups and improve breathing in adults aged 40–75 with moderate-to-severe COPD and recent exacerbations.
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BBT002 in healthy adults and adults with COPD
This tests BBT002 versus placebo in healthy adults and people with COPD to see if it is safe and how the body responds to it.
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Cough monitoring to detect worsening COPD early
This project will try continuous, automatic cough counting with a Hyfe wrist device and smartphone app to see if changes in cough frequency can warn adults with COPD about upcoming flare-ups.
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Mindful-Breath program for people with COPD
This program will test if a personalized Mindful-Breath telehealth and mindfulness approach helps adults aged 50–80 with COPD feel less stressed and become more active.
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Single Inhaler Triple Therapy for COPD: 12-Week Test of FF/UMEC/VI in Moderate-to-Severe Dyspnea
This study tests whether a once-daily FF/UMEC/VI inhaler for 12 weeks helps adults with COPD, including those at low or high risk of flare-ups, by improving lung ventilation on 129-Xe MRI.
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Progressive walking plus elastic-band exercise for people with COPD
This study tests whether a three-month progressive walking program combined with elastic-band resistance and a wearable tracker can help people aged 40 and older with COPD and a history of smoking.
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Improving how adults with COPD and asthma stick to and use their inhalers
This project will test whether a mobile/web app plus targeted training helps adults with COPD or asthma use their inhalers correctly and keep taking their inhaled medicines.
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Managing multiple medications in older adults with chronic diseases
This project will see if taking many different medicines changes the health outlook of people aged 65 and older who have chronic conditions.
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No continuous sedation versus daily sedation interruption for ventilated COPD patients
This compares no continuous sedation to daily sedation breaks to see which approach gives more ventilator-free days for adults with COPD on a breathing machine.
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Pulmonary vascular phenotype in adults with COPD.
This registry collects right-heart catheterization and clinical data from adults with COPD to better understand pulmonary hypertension in this group.
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AZD6793 for people with moderate to very severe COPD
This trial will test three different doses of the oral medicine AZD6793 against a placebo in adults with moderate to very severe COPD to see if it improves symptoms and reduces flare-ups.
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Omalizumab for people with COPD who are allergic to common indoor allergens
This trial will test whether monthly injections of omalizumab (Xolair) help people aged 40+ with COPD who are allergic to and exposed to common indoor allergens reduce symptoms or exacerbations.
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Dupilumab for adults with COPD and high blood eosinophils in routine care
This study will try dupilumab in adults with uncontrolled COPD and high blood eosinophils to see if it improves symptoms, quality of life, and safety over 24 months in routine care.
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Finding undiagnosed chronic lung problems in people with other long-term health conditions in Brazil
This project will try two short questionnaires (COLA and SBQ) plus breathing tests to find undiagnosed asthma, COPD, or similar lung problems in people with long-term conditions who attend primary care in São Carlos and São Paulo, Brazil.
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Home-based telerehabilitation versus center-based pulmonary rehabilitation for COPD
This trial will test whether home-based telerehabilitation works as well as center-based pulmonary rehabilitation for adults aged 45–80 with moderate to severe COPD.
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How inhaler use affects oral health in people with COPD
This trial will test whether a short mouth-care training helps people with COPD who use inhalers keep their mouths healthier.
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Intermittent intrapulmonary deflation to ease breathlessness after exercise in COPD
This trial will test whether a home device that applies intermittent negative pressure during exhalation reduces shortness of breath after exercise in adults with moderate to severe COPD.
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Understanding COPD Phenotypes and Treatable Traits
This study is trying to find out different types of COPD and specific traits in patients that can be treated to help improve their health and management of the disease.
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Autologous bronchial basal cell transplant to treat COPD
This trial tests whether a patient’s own bronchial basal cells, expanded in a lab, can be safely infused into their lungs to improve lung function in COPD.
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Identifying COPD in lung cancer screening patients
This study is trying to find out how many people aged 50 to 80 who are getting lung cancer screenings actually have undiagnosed COPD and how early diagnosis might help them.
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Hydrocortisone versus Prednisolone for COPD flare-ups
This test compares hydrocortisone and prednisolone to see which works better and causes fewer side effects in people 40 and older who have a COPD exacerbation.
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Smartphone program to improve quality of life for people with COPD
This study will test a smartphone-based self-management program (3S-C) to see if it helps people with COPD feel better, manage their condition, and use less healthcare.
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Evaluating Tezepelumab for Adults with Moderate to Very Severe COPD
This study is testing if a new medication called tezepelumab can help adults with moderate to very severe COPD feel better and reduce flare-ups compared to a placebo.
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Evaluating Tezepelumab for Adults with Moderate to Very Severe COPD
This study is testing if a new medication called tezepelumab can help adults with moderate to very severe COPD feel better and reduce their flare-ups over a treatment period of up to 76 weeks.
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Understanding airway mucus blockages in asthma, COPD, and chronic cough across Canada
This project will use chest CT scans and clinical data to see if mucus plugs in the airways are linked to symptoms in adults with moderate-to-severe asthma, COPD, or chronic cough.
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Digital health app to help manage Chronic Obstructive Pulmonary Disease
This study is testing a new mobile app that helps people with COPD manage their symptoms better by providing personalized breathing exercises and support from physiotherapists.
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Pulmonary rehabilitation for patients with COPD in rural areas
This study is testing a special rehabilitation program for people with COPD living in rural areas to see if it helps them breathe better and improves their quality of life.
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Understanding the impact of multimorbidity on chronic airway diseases
This study looks at how having multiple health issues affects people with chronic lung diseases like COPD, asthma, or bronchiectasis to help improve their care and treatment.
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Extra oxygen during outpatient pulmonary rehabilitation for people with COPD who desaturate with exercise
This trial will see if giving supplemental oxygen during a 3-month outpatient pulmonary rehabilitation program helps people with COPD who lose oxygen during exercise.
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WearME system to monitor COPD severity and lung function
This project will test whether the WearME wearable can accurately track breathing and lung function in adults with COPD by comparing its readings to standard lung tests.
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Magnetic stimulation to strengthen the diaphragm in COPD patients
This study is testing if a new magnetic treatment can help strengthen the diaphragm and improve breathing for people with COPD who are also doing rehabilitation exercises.
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Comparing breathing, muscle, activity, and sleep measures in adults with COPD, PRISm, and healthy people
This project tries to see if breathing and limb muscle strength, oxygen levels, artery stiffness, physical activity and sleep differ between adults over 40 with PRISm, adults with stable COPD, and healthy adults.
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Dynamic Chest X-ray for COPD Diagnosis
This study tests whether dynamic chest radiography can help diagnose COPD in adults, alongside traditional tests.
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Personalized music feedback to improve walking for people with COPD
This study is testing whether a mobile app that uses personalized music can help people with COPD stick to their walking exercises and feel less tired while doing them.
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Understanding COPD and cardiovascular disease in Greece
This study is trying to learn more about people in Greece who have both COPD and heart disease to see how these conditions affect their lives and healthcare needs over two years.
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Improving indoor air quality for patients with COPD
This study is testing whether using an air cleaner can improve indoor air quality and help people with COPD feel better and have fewer breathing problems.
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Using hypnosis to improve comfort during non-invasive ventilation for COPD and obese patients in intensive care
This study is testing if using hypnosis can help make patients with COPD and obesity feel more comfortable during non-invasive ventilation in the intensive care unit.
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Registry for patients with chronic airway diseases
This study is gathering information from people with chronic airway diseases like COPD and asthma to better understand their conditions and find ways to improve their care.
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Collecting biological samples from individuals with and without lung disease
This study is collecting blood, urine, and airway samples from both healthy people and those with lung diseases to see how their biology differs and learn more about these conditions.
Related topics
Quick answers
How many Chronic Obstructive Pulmonary Disease (COPD) clinical trials are recruiting right now?
80, as of November 12, 2026. 5 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 52 countries. The most sites are in China (14 trials), United States (13 trials), United Kingdom (8 trials), France (7 trials), Denmark (6 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 7, Phase 4: 4, Phase 1/2: 3, Phase 3: 3. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.