Controlled versus standard oxygen therapy for ICU COPD with acute exacerbation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In ICU patients with acute COPD exacerbations, the study compares a controlled oxygen strategy (target SpO2 88-92%) to standard oxygen therapy (SpO2 >94%). It is a randomized controlled design aiming to see if tighter oxygen targets can shorten the time on mechanical ventilation. Secondary outcomes include 28‑day mortality and other clinical metrics. The trial addresses a gap in evidence for oxygen targets in critically ill COPD patients. Eligible participants are adults with COPD admitted to ICU for an acute exacerbation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 40 years
* Established diagnosis of chronic obstructive pulmonary disease (COPD) according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria
* Admission to the intensive care unit for an acute exacerbation of COPD, with or without respiratory acidosis
* Written informed consent provided by the participant or their legally authorized representative

Exclusion Criteria:

* Endotracheal intubation performed before enrollment
* Severe decompensated heart failure with a left ventricular ejection fraction \< 30%
* Active terminal malignancy
* Refusal to participate in the study

Where it's running

• Taher Sfar Mahdia Hospital
  Mahdia, Mahdia Governorate, Tunisia Recruiting
• Dhouha Ben Braiek
  Kairouan, Tunisia Not yet recruiting

Study contacts

• Study coordinator: Hajer Nouira
• Email: nouirahajer@gmail.com
• Phone: +21622858699

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.