Effects of Wood Smoke on Lung Health in Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study uses controlled human exposures to woodsmoke (from Lodgepole Pine) at three concentrations and a filtered-air control to explore potential links between wildfire smoke and chronic lung diseases. Participants are healthy adults aged 19 to 80 and will undergo 2-hour exposure sessions over multiple days with varying PM2.5 levels. The goal is to understand how exposure concentration, intensity, and duration influence lung function, inflammation, and immunomodulatory responses, building biological plausibility for connections to asthma, COPD, and lung cancer. Findings may shed light on which individuals are most vulnerable to wildfire smoke and the mechanisms behind long-term respiratory effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy Adults between the ages of 19 to 80 (12 of each biological sex assigned at birth).

Exclusion Criteria:

1. Current smoker (within six months before screening; potential to confound exposure effects).
2. History or current diagnosis of any respiratory conditions (including, but not limited to asthma or chronic obstructive pulmonary disease (COPD), asthma/COPD overlap) or other medical conditions that the study physician determines may impact participant safety.
3. Any comorbidities or other concerns identified by the study physician which may impact study participation.
4. For participants of child-bearing potential: Current pregnancy, or plans to become pregnant during study enrolment.

Where it's running

• Air Pollution Exposure Lab
  Vancouver, British Columbia, Canada Recruiting

Study contacts

• Principal investigator: Chris Carlsten, MD, MPH — University of British Columbia
• Study coordinator: PJ (Parteek) Johal, BCS
• Email: p.johal@ubc.ca
• Phone: 604-875-5132

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.