Improving indoor air quality for patients with COPD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of an air cleaner intervention in enhancing indoor air quality for individuals with Chronic Obstructive Pulmonary Disease (COPD). It is a multi-center, randomized, double-blind, sham-controlled trial that will enroll 770 former smokers diagnosed with COPD over a four-year period. Participants will be followed for one year, with the primary focus on respiratory-specific quality of life and secondary outcomes including the rate of acute exacerbations and rescue medication use.

Why it matters

Who can join: the full rules

Inclusion criteria

To be eligible, subjects must meet all these criteria:

1. Age ≥ 40 years.
2. Self-report of physician diagnosis of COPD.
3. Spirometry confirmed airway obstruction (post-bronchodilator spirometry of forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) \< 0.7) as defined by the Global Initiative for Obstructive Lung Disease (GOLD) criteria (6, 11)
4. Tobacco exposure ≥ 10 pack-years. This refers to regular cigarette tobacco consumption.
5. Self-reported former smoker of at least 6 months' duration. This does not include e-cigarette use.
6. COPD Assessment Test (CAT) score ≥ 10, Modified Medical Research Council dyspnea scale (mMRC) ≥ 2, or history of moderate or severe exacerbation in the past 12 months (as defined by history of receiving a course of systemic corticosteroids or antibiotics for respiratory problems; or visiting an emergency department or being hospitalized for a COPD exacerbation within the past 12 months.)

Exclusion criteria

To be eligible, subjects must not meet any one of these criteria:

1. Living in a location other than home (e.g., long-term care facility, nursing home)
2. Other chronic lung diseases, except asthma
3. Condition with less than a year of life expectancy (e.g., metastatic cancer) or in hospice
4. Spends \>2 months per year in location other than home; or plans to change residence in the next 12 months
5. Pregnant or breastfeeding
6. Current air cleaner use in the home (\*If the individual is willing to discontinue use of the personal air cleaner, this person can be eligible if all other eligibility has been met)
7. Inability to bring air cleaners (about 15 pounds each) into home, either by self, friend, or relative
8. Deemed by the study investigator to be unable to complete study protocol, including likely lack of internet connectivity
9. Participating in another interventional clinical trial

Where it's running

• University of Alabama, Lung Health Center
  Birmingham, Alabama, United States Recruiting
• University of California, Los Angeles
  Los Angeles, California, United States Recruiting
• University of Iowa
  Iowa City, Iowa, United States Recruiting
• University of Maryland
  Baltimore, Maryland, United States Recruiting
• Johns Hopkins
  Baltimore, Maryland, United States Recruiting
• Tidal Health
  Salisbury, Maryland, United States Recruiting

Study contacts

• Study coordinator: Stephan Ehrhardt, MD, PhD
• Email: sehrhar6@jhu.edu
• Phone: (410) 502-3872

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.