Classifying treatable traits and breathlessness perception in people with COPD or asthma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project will enroll about 800 adults with physician-diagnosed COPD or asthma and 150 age-matched healthy controls to perform comprehensive clinical phenotyping. Participants will complete standardized dyspnea perception measures, spirometry, lung volumes, diffusion capacity, FeNO, blood tests (including CBC and IgE/allergen screening), HRCT, and health-related quality-of-life questionnaires at baseline and follow-up visits. A subset will undergo functional MRI of the brain to study neural correlates of breathlessness perception. No investigational treatments are given; the aim is to identify subtypes based on perception and their relationships to other treatable characteristics and outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Inclusion Criteria for Chronic Airway Disease Patients:

  1. Age 20-75 years.
  2. Meets the diagnostic criteria for COPD according to the 2022 GOLD guidelines OR meets the diagnostic criteria for asthma according to the 2022 GINA guidelines.
  3. Willing and able to provide informed consent.
* Inclusion Criteria for Healthy Controls:

  1. Age ≥20 years.
  2. No history of asthma symptoms or diagnosis of chronic respiratory diseases such as asthma or COPD.
  3. Willing and able to provide informed consent and comply with the study protocol.

Exclusion Criteria:

* (applies to all participants):

  1. Respiratory tract infection, COPD acute exacerbation, or asthma acute exacerbation within the past 3 months.
  2. Presence of other diseases causing significant lung tissue destruction, such as severe bronchiectasis or tuberculosis.
  3. History of thoracic or abdominal surgery within the past 3 months.
  4. Heart rate \>120 beats per minute.
  5. Ongoing anti-tuberculosis treatment.
  6. Presence of other severe, uncontrolled systemic diseases.
  7. Pregnant or lactating women.

Where it's running

• Beijing Chao-Yang Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Kewu Huang, M.D. — Beijing Chao Yang Hospital
• Study coordinator: Shuya Huang, M.D.
• Email: 17852063100@163.com
• Phone: +8617852063100

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.