Finding undiagnosed chronic lung problems in people with other long-term health conditions in Brazil
Official title: Case-Finding for Chronic Respiratory Diseases in People Living With Other Long-Term Conditions
Run by University College, London · NCT07050823 · Data updated 2026-11-12
This project will try two short questionnaires (COLA and SBQ) plus breathing tests to find undiagnosed asthma, COPD, or similar lung problems in people with long-term conditions who attend primary care in São Carlos and São Paulo, Brazil.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 30 Years and up |
| Sex | All |
| Enrollment | 859 (estimated) |
| Sponsor | University College, London Academic / other |
| Locations | 2 sites (São Carlos, São Paulo and 1 other locations) |
| Status | Recruiting |
| Started | July 1, 2025 |
| Main results expected | December 2026 |
| Study ends | July 2027 |
| Registry record updated | July 25, 2025 |
| Trial ID | NCT07050823 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults attending primary health care in São Carlos or São Paulo with one or more diagnosed non-respiratory long-term conditions (for example cardiovascular disease, diabetes, or hypertension), who are clinically stable, able to complete questionnaires and perform spirometry, and not pregnant or currently treated for active pulmonary tuberculosis.
✕Probably not a fit
People already known to have asthma or COPD, those who are clinically unstable, pregnant, currently have an acute respiratory infection or active tuberculosis, have cognitive impairment preventing questionnaire completion, or have contraindications to spirometry are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a cross-sectional observational study enrolling about 859 adults with one or more non-respiratory long-term conditions who attend primary health care units in São Carlos and São Paulo. Participants will complete the COLA-6 questionnaire (and SBQ) and undergo lung function testing including post-bronchodilator spirometry and fractional exhaled nitric oxide (FeNO) to establish a reference diagnosis. The investigators will compare the questionnaire results against the spirometry gold standard and report diagnostic performance using receiver operating characteristic (ROC) curves and area under the curve. Routine PHC settings (Basic Health Units and Family Health Units) are used to reflect real-world case-finding in Brazilian primary care.
Why it matters
Potential benefit: If successful, the approach could help primary care teams find more people with previously undiagnosed chronic respiratory disease so they can get appropriate treatment earlier.
How similar studies have gone: Questionnaire-based case-finding combined with spirometry has shown promise in other low-resource and primary care settings, but performance varies by population and the COLA-6 tool's accuracy in Brazilian PHC is being specifically tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Attending primary health care services in Brasil. Diagnosed with one or more existing, non-respiratory long-term conditions such as cardiovascular disease, diabetes or hypertension. Exclusion Criteria: Clinically unstable in the past month (defined as worsening symptoms requiring emergency care or hospitalization). Current pregnancy. Active pulmonary tuberculosis or undergoing treatment for pulmonary tuberculosis. Current acute respiratory infection. Cognitive impairment that prevents understanding of the case-finding questionnaire, defined as MMSE score ≤20. Contraindications to spirometry. Declines to participate in the study.
Where it's running
-
Multiple primary care sites
São Carlos, São Paulo, Brazil Recruiting -
Multiple primary care sites
São Paulo, São Paulo, Brazil Not yet recruiting
Study contacts
- Principal investigator: John R Hurst, PhD FRCP — University College London Hospitals
- Study coordinator: Trial Manager
- Email: vivianecastello@ufscar.br
- Phone: (+5516) 99992-4777
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Chronic Respiratory Disease Participant Engagement
This study tests whether adults with long-term lung conditions can get comfortable with a clinical trials unit and research team before joining future trials.
-
Breztri real-world safety and effectiveness in Korean patients with COPD or asthma
This post-marketing study tests Breztri in real-world Korean patients with COPD or asthma to see how safe it is and how well it works when used as usual care.
-
Effects of Wood Smoke on Lung Health in Adults
This study tests how different levels of woodsmoke exposure affect lung function and inflammatory responses in healthy adults.
-
Understanding airway mucus blockages in asthma, COPD, and chronic cough across Canada
This project will use chest CT scans and clinical data to see if mucus plugs in the airways are linked to symptoms in adults with moderate-to-severe asthma, COPD, or chronic cough.
-
Understanding the impact of multimorbidity on chronic airway diseases
This study looks at how having multiple health issues affects people with chronic lung diseases like COPD, asthma, or bronchiectasis to help improve their care and treatment.
-
Registry for patients with chronic airway diseases
This study is gathering information from people with chronic airway diseases like COPD and asthma to better understand their conditions and find ways to improve their care.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.