Hydrocortisone versus Prednisolone for COPD flare-ups

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a cluster-randomized trial that assigns participating hospitals or units to treat patients with either hydrocortisone or prednisolone for acute COPD exacerbations. Adults aged 40 and older presenting with an acute exacerbation of COPD are enrolled and receive the assigned systemic corticosteroid according to local protocols. The primary outcome is readmission for COPD exacerbation or all-cause mortality within 30 days, and safety outcomes include treatment-related side effects. Key exclusions include conditions that require a specific corticosteroid, pregnancy or breastfeeding, and active tuberculosis or invasive fungal infection.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥40 years
* Chronic obstructive pulmonary disease with acute exacerbation, unspecified: ICDJ44

Exclusion Criteria:

* All diagnoses that would merit treatment with a specific corticosteroid
* Pregnant or breastfeeding women
* Active tuberculosis or invasive fungal infection

Where it's running

• Bornholm Hospital
  Rønne, Bornholm, Denmark Recruiting
• Amager Hospital
  Copenhagen, Copenhagen City, Denmark Recruiting
• Bispebjerg Hospital
  Copenhagen, Copenhagen City, Denmark Recruiting
• Frederiksberg Hospital
  Frederiksberg, Copenhagen City, Denmark Recruiting
• Gentofte Hospital
  Hellerup, Copenhagen City, Denmark Recruiting
• Herlev Hospital
  Herlev, Copnhagen Surroundings, Denmark Recruiting

Study contacts

• Study coordinator: Jens-Ulrik Stæhr Jensen, MD, PHD
• Email: jens.ulrik.jensen@regionh.dk
• Phone: 38673057

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.