Understanding airway mucus blockages in asthma, COPD, and chronic cough across Canada

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational consortium brings together clinicians, scientists, and patient partners across Canada to quantify airway mucus occlusions using chest computed tomography and standardized clinical assessments. Adults with physician-confirmed moderate-to-severe asthma, COPD by GOLD criteria, or refractory/unexplained chronic cough, plus healthy volunteers, will be enrolled and imaged. Centralized image analysis will identify and measure mucus plugs and correlate those findings with symptoms, lung function, and clinical scores. The project will create a shared dataset and standard methods to support future research and potential targeted treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Males and females (≥18 years old)

Asthma: Respiratory physician confirmed diagnosis of moderate-to-severe asthma and Historical objective evidence of asthma and/or specialist/respirologist confirmation (post-bronchodilator reversibility and/or methacholine bronchoprovocation test \<8 mg/mL)

COPD: Respiratory physician confirmed diagnosis of COPD that is moderate-to-severe according to GOLD criteria (post-bronchodilator FEV1/FVC\<LLN and FEV1\< 80%pred) and CAT score ≥10 or mMRC score ≥ 2

Chronic cough: Refractory Chronic Cough (RCC) and Unexplained Chronic Cough (UCC) lasting \>1 year with Normal chest radiograph and no airflow obstruction (FEV1/FVC \>Lower Limit of Normal)

Healthy participants: No history of respiratory disease or other pulmonary disorders and no use of inhaled medications or corticosteroids with normal spirometry and Modified Medical Research Council (mMRC) Dyspnea Scale =\<1

Exclusion Criteria:

* Pregnant or breastfeeding
* Current smoker or \>10 yr pack history or smoked within the last 6 months
* Exacerbation within 4 weeks of recruitment
* Preterm birth (≤36 weeks gestation) or perinatal complications
* History of other pulmonary disorders
* Specialist/Respirologist suspects primary ciliary dyskinesia (PCD)
* Current use of mucolytic medications
* Memory, cognitive, or psychiatric limitations that may prevent optimal participation
* Treatment with current biologic therapy: anti-IgE mAb within 130 days, anti-IL-4/4R, IL-5/5R, IL-13, or TSLP within 2 months or 5 half-lives whichever is longer prior to visit 1

Where it's running

• St. Joseph's Healthcare Hamilton
  Hamilton, Ontario, Canada Recruiting
• St. Paul's Hospital
  Vancouver, British Columbia, Canada Not yet recruiting
• Robarts Research Institute
  London, Ontario, Canada Not yet recruiting
• The Ottawa Hospital
  Ottawa, Ontario, Canada Not yet recruiting
• McGill University Health Centre
  Montreal, Quebec, Canada Not yet recruiting
• Quebec Heart and Lung Institute - Laval University
  Québec, Quebec, Canada Not yet recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.