No continuous sedation versus daily sedation interruption for ventilated COPD patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective comparison enrolls 60 adults with COPD exacerbation who require invasive mechanical ventilation at Benha University Hospitals. Participants are divided into two equal groups: one managed without continuous sedation and the other managed with daily interruption of sedation, with ventilator-free days as the primary outcome. Key exclusions include pregnancy, renal or hepatic impairment, neurological or psychiatric disorders, and allergy to the sedative. Patients are followed through their ICU course to capture ventilation duration and related clinical outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients of both sex aged 18 years or older
* The study will include 60 patients divided into 2 equal groups
* Invasive mechanical ventilation
* Patients with COPD patients (post-bronchodilator FEV1/FVC\< 70, and under follow through the department outpatient clinic) exacerbation admitted to the ICU and required invasive mechanical ventilation were recruited.

Exclusion Criteria:

Allergy to sedative which will be used

* renal or hepatic impairment
* proven or suspected psychiatric or neurological impairment
* pregnancy

Where it's running

• Benha University Hospitals
  Banhā, Qalyubia Governorate, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.