D-RSBI vs RSBI to predict weaning success in COPD patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational cohort compares two weaning indices—D-RSBI measured by diaphragmatic ultrasound and the traditional RSBI—in COPD patients undergoing spontaneous breathing trials. Participants are mechanically ventilated for more than 24 hours and meet standard readiness criteria, with diaphragmatic ultrasound performed during SBTs and follow-up for 72 hours after extubation to determine weaning outcomes. The study is conducted at Sohag University Hospital, with data collected on predictor accuracy and timing to successful extubation. Inclusion requires stable hemodynamics, adequate oxygenation, and the ability to initiate spontaneous breathing; exclusions include neuromuscular disorders, diaphragmatic pathology, or poor ultrasound windows.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Mechanically ventilated COPD patients fulfilling standard weaning readiness criteria.
* Invasive mechanical ventilation for more than 24 hours before spontaneous breathing trial.
* Hemodynamically stable without significant vasopressor support.
* Adequate oxygenation with FiO2 ≤ 0.5 and PEEP ≤ 8 cmH2O .
* Preserved mental status and ability to initiate spontaneous breathing.
* Successful tolerance of spontaneous breathing trial conducted on CPAP mode with pressure support ≤ 8 cmH2O.

Exclusion Criteria:

* Refusal of consent
* Neuromuscular disease, phrenic nerve palsy, or diaphragmatic paralysis.
* Large pneumothorax or pathology interfering with ultrasound assessment.
* Terminal extubation.
* Recent major thoracic surgery.
* Poor sonographic window despite repeated attempts.

Where it's running

• Sohag University Hospital
  Sohag, Sohag Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Ahmed Atef Mohamed, MBBCh
• Email: ahmed_ateff_post@med.sohag.edu.eg
• Phone: +201006973892

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.