Condition

Advanced Cancer clinical trials and research

• 82Clinical trials
• 64NIH research projects
• 25Countries

Newest Advanced Cancer clinical trials

All recruiting trials (82)

• Concise coaching to guide decisions for advanced cancer patients considering palliative procedures

  A coaching program delivered by lay providers will test whether it helps adults with advanced cancer make better, patient-aligned decisions about palliative surgeries or similar interventions.

  Recruiting Singapore General Hospital · Singapore · NCT07789093

• Primary Palliative Care: A Feasibility Project for Family Health Units

  This feasibility trial tests a GP training program plus a structured 12-week palliative-care visit plan to see if it can be carried out in primary care for adults with advanced illness.

  Recruiting University of Coimbra · Coimbra and 1 other locations · NCT07737899

• Virtual Group Resilient Living for Advanced Cancer

  A group-based online program tests whether seven weekly sessions can reduce anxiety and fatigue and improve quality of life for adults with advanced cancer.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07659158

• IV contrast-enhanced CBCT with HyperSight for image guidance in advanced cancer radiotherapy

  This study tests whether giving IV contrast during cone-beam CT helps doctors see the tumor better during radiotherapy in people with advanced cancer.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07648160

• Single-session celiac plexus SBRT using a simulation-free adaptive workflow for cancer-related pain

  A pilot test to see if a one-day, simulation-free adaptive radiotherapy process can safely deliver celiac plexus SBRT to adults with advanced pancreatic or other cancers.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07636382

• UI-102 in advanced cancers (phase 1/2) first-in-human

  A first-in-human study tests UI-102, given to adults with advanced solid tumors to see if it is safe and shows signs of benefit.

  Recruiting at 3 sites Phase 1/2 United Immunity, co., Ltd. · Dallas, Texas and 2 other locations · NCT07605962

• Givastomig with nivolumab and chemotherapy for CLDN18.2-positive metastatic stomach or gastroesophageal junction cancer

  This study will see if adding givastomig to nivolumab plus standard chemotherapy helps adults with CLDN18.2- and PD-L1-positive metastatic stomach or gastroesophageal junction cancer live longer without their disease getting worse.

  Recruiting at 5 sites Phase 2 I-Mab Biopharma US Limited · Goodyear, Arizona and 5 other locations · NCT07432295

• Resilience-building tool to help with advance care planning

  This study tests a web-based resilience program called ROCKS to see if it helps adults with advanced cancer and their family caregivers finish advance directives better than usual care.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT07428278

• PF-07994525 in advanced cancers: a first-in-human dose-escalation study

  A single-arm, early-phase study tests PF-07994525 in adults with advanced cancers who have exhausted other therapies to see if it’s safe and shows any signs of tumor activity.

  Recruiting at 29 sites Phase 1 Pfizer · Denver, Colorado and 29 other locations · NCT07426757

• Spiritual care interventions for people with advanced cancer

  This trial tests two spiritual care programs for people with advanced cancer to see if they improve spiritual well-being and how they use healthcare services like hospice and ICU.

  Recruiting at 3 sites Weill Medical College of Cornell University · New York, New York and 2 other locations · NCT07408310

• Pilot randomized test of a social network program for older adults with advanced cancer

  This pilot will try the SONATA social network program to see if it helps adults 65 and older with advanced cancer manage their care better and improve quality of life.

  Recruiting University of Rochester · Rochester, New York · NCT07393529

• BMS-986504 with olaparib for advanced solid tumors that have MTAP loss

  This study tests whether combining BMS-986504 with olaparib is safe and has anti-tumor activity in adults with advanced solid tumors that have MTAP loss.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT07382544

• Liver‑artery chemotherapy plus immunotherapy for advanced unresectable intrahepatic cholangiocarcinoma

  This test tries whether giving gemcitabine+cisplatin directly into the liver artery (HAIC) combined with a PD‑1/PD‑L1 immunotherapy (durvalumab or pembrolizumab) helps people with advanced, initially unresectable intrahepatic cholangiocarcinoma.

  Recruiting Phase 2 Eastern Hepatobiliary Surgery Hospital · Shanghai, Shanghai Municipality · NCT07364305

• Identifying off-guideline treatments that may work for advanced cancer

  This project tests whether genomic and lab-based functional tests can help doctors choose FDA-approved off-guideline drugs that might work for people with advanced cancer.

  Recruiting Cancer Commons · Palo Alto, California · NCT07343024

• Testing TQB3122 capsules in adults with advanced solid tumors

  This trial will try TQB3122 capsules in adults with advanced solid tumors who have exhausted standard treatments to check safety, how the body handles the drug, and any early signs it might work.

  Recruiting Phase 1 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Beijing, Beijing Municipality and 4 other locations · NCT07269145

• Chaplain-clinician PEACE spiritual care for people with advanced cancer

  This pilot will try a chaplain-clinician spiritual care program (PEACE) to see if it is feasible, acceptable, and can change how people with advanced cancer let their religious beliefs influence medical decisions.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT07246954

• Electronic symptom reporting to connect people with advanced cancer to palliative care

  This project tests whether weekly electronic symptom surveys plus monthly needs questionnaires can help adults with advanced metastatic solid tumors get connected to palliative and supportive care sooner.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT07195513

• Care coach-led palliative surgical and rehabilitation care for people with advanced cancer

  This program will test whether a care coach-led palliative surgical oncology approach paired with rehabilitation helps adults with stage 3–4 solid cancers who are planning major elective surgery.

  Recruiting at 2 sites Singapore General Hospital · Singapore and 1 other locations · NCT07133269

• PHN-012 for people with advanced colon, lung (NSCLC), or pancreatic cancer.

  This trial will try PHN-012, a new antibody-drug conjugate, in people with advanced colon, non-small cell lung, or pancreatic cancer who have already received other treatments.

  Recruiting at 26 sites Phase 1 Pheon Therapeutics · Los Angeles, California and 25 other locations · NCT07127874

• Focused Acceptance and Commitment Therapy (FACT) for people with advanced cancer

  This program will try a short therapy called Focused Acceptance and Commitment Therapy (FACT) to see if it reduces worries about dying in people with advanced cancer.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT07105033

• Trastuzumab plus chemotherapy versus chemotherapy alone for first-line HER2-positive advanced biliary tract cancer

  This trial will test if adding trastuzumab to standard first-line chemotherapy helps people with HER2-positive advanced or metastatic biliary tract cancer control their disease longer than chemotherapy alone.

  Recruiting at 3 sites Phase 3 Tata Memorial Centre · Muzaffarpur, Bihar and 5 other locations · NCT07062263

• TA-DA: a patient decision tool to help with treatment choices after second-line therapy

  This project will test a patient decision aid (TA-DA) to help adults with advanced cancer who have already received at least two lines of palliative systemic therapy talk with their clinicians about third-line or later treatment options.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT07009886

• Personalized neoantigen peptide vaccine for solid tumors

  This trial will test whether a custom neoantigen peptide vaccine given with poly-ICLC and an anti-PD-1 drug can help the immune system fight solid tumors in adults with advanced or high-risk disease.

  Recruiting Phase 1/2 Seqker Biosciences, Inc. · Bangkok · NCT07002203

• HC006 plus a PD-1 inhibitor for advanced solid tumors

  This trial tests whether adding HC006 to a PD-1 inhibitor helps people with advanced solid tumors.

  Recruiting Phase 1 HC Biopharma Inc. · Shanghai, Shanghai Municipality · NCT06963814

• Monthly digital financial hardship screening for people with advanced cancer

  This project tests whether monthly remote digital financial hardship screening helps adults with advanced or metastatic cancer who are receiving non-curative systemic therapy.

  Recruiting at 7 sites Alliance Foundation Trials, LLC. · Phoenix, Arizona and 6 other locations · NCT06963723

• Program to support patients with advanced gastrointestinal and gynecologic cancers

  This study is testing a new support program to see if it can help people with advanced gastrointestinal and gynecologic cancers feel better and need less hospital care.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06936878

• Using Patient-Derived Tumor Organoids to Choose a Drug for Pancreatic Cancer

  This study tests whether selecting a drug based on a patient’s tumor organoids helps people with advanced pancreatic cancer respond to treatment.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT06813079

• Pilot trial of spiritual care for black patients with advanced cancer

  This study is testing whether spiritual care can improve the well-being and planning readiness of black patients with advanced cancer.

  Recruiting at 2 sites Weill Medical College of Cornell University · Brooklyn, New York and 1 other locations · NCT06811376

• Treatment of metastatic solid tumors with SLV-154

  This study is testing a new treatment called SLV-154 for people with advanced solid tumors, like certain types of lung and breast cancer, to see how safe it is and how well it works.

  Recruiting at 12 sites Phase 1 Solve Therapeutics · Newport Beach, California and 11 other locations · NCT06771219

• SXRN Plasmid DNA Technique in Advanced Solid Tumors

  This early-phase study tests the safety and tolerability of SXRN plasmid DNA given at different doses in adults with advanced solid tumors who have exhausted standard therapies.

  Recruiting Early Phase 1 Jiangsu Nutai Biologics Co., Ltd · Beijing · NCT06736275

• Evaluating ALK202 for advanced solid tumors

  This study is testing a new drug called ALK202 to see if it is safe and effective for adults with advanced solid tumors.

  Recruiting at 4 sites Phase 1 Shanghai Allink Biotherapeutics Co., Ltd. · Margate, Florida and 3 other locations · NCT06707610

• Testing TQB3002 in patients with advanced cancers

  This study is testing a new pill called TQB3002 to see if it can help people with advanced cancers that haven't responded to other treatments.

  Recruiting Phase 1 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Guangzhou, Guangdong and 10 other locations · NCT06662760

• Evaluating ALK201 for advanced solid tumors

  This study is testing a new drug called ALK201 to see if it is safe and effective for adults with advanced solid tumors.

  Recruiting at 38 sites Phase 1/2 Shanghai Allink Biotherapeutics Co., Ltd. · Denver, Colorado and 37 other locations · NCT06656390

• Palliative care intervention for older adults with advanced cancer in skilled nursing facilities

  This study is testing a new palliative care program for older adults with advanced cancer in nursing facilities to see if it helps them and their caregivers make better medical decisions compared to regular care.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06616298

• Analyzing patient characteristics for advanced cancer treatment

  This study looks at the personal and lifestyle factors of cancer patients starting their first treatment to see how these affect their response to the treatment.

  Recruiting at 9 sites Centro Nacional de Investigaciones Oncologicas CARLOS III · A Coruña, A Coruña/ Galicia and 8 other locations · NCT06590506

• Assessing the safety and effectiveness of BC3195 in advanced cancer patients

  This study is testing a new drug called BC3195 to see if it is safe and effective for people with advanced cancer who haven't had success with other treatments.

  Recruiting Phase 1 Biocity Biopharmaceutics Co., Ltd. · Cleveland, Ohio · NCT06548672

• Evaluating AGX101 for advanced solid tumors

  This study is testing a new drug called AGX101 to see if it can help people with advanced solid tumors who haven't had success with other treatments.

  Recruiting at 7 sites Phase 1 Angiex, Inc. · Los Angeles, California and 6 other locations · NCT06440005

• Combination treatment for advanced pancreatic cancer

  This study is testing a new combination of treatments for people with advanced pancreatic cancer who haven't had treatment before to see if it helps manage their disease better.

  Recruiting Phase 2 Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Beijing, Beijing Municipality · NCT06405490

• Imaging for treatment optimization in advanced prostate cancer

  This study is testing if special imaging can help doctors understand how well radiation treatments work for people with advanced prostate cancer and improve their outcomes.

  Recruiting Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland · NCT06389097

• Oral Alintegimod with Ipilimumab followed by Nivolumab for advanced cancer

  This study is testing if a new oral medication called Alintegimod, combined with two other cancer treatments, can help people with advanced solid tumors feel better and live longer.

  Recruiting at 4 sites Phase 1/2 7 Hills Pharma, LLC · Aurora, Colorado and 4 other locations · NCT06362369

• Combining two immunotherapy drugs for MSI-H/dMMR advanced stomach and gastroesophageal junction cancer

  This trial will try two immunotherapy drugs (balstilimab and botensilimab) as first treatment for adults with MSI‑H/dMMR, HER2‑negative advanced or metastatic stomach or gastroesophageal‑junction cancer whose tumors have PD‑L1 CPS ≥5, and will compare that to standard chemotherapy with nivolumab.

  Recruiting at 7 sites Phase 3 Centre Leon Berard · Brest and 6 other locations · NCT06346197

• Using olanzapine to improve survival in patients with advanced gastrointestinal and lung cancer

  This study is testing if adding the medication olanzapine to regular cancer treatment and nutritional advice can help people with advanced gastrointestinal and lung cancers live longer and feel better.

  Recruiting Phase 3 Qinghai Red Cross Hospital · Xining, Qinghai · NCT06338683

• Collecting data on advanced and rare cancers treated with personalized medicine

  This study is trying to see how people with advanced and rare cancers respond to personalized treatments when they have run out of other options.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06285500

• Testing MGC026 in patients with advanced solid tumors

  This study is testing a new treatment called MGC026 to see if it can help adults with advanced solid tumors that can't be removed or have spread to other parts of the body.

  Recruiting at 12 sites Phase 1 MacroGenics · Los Angeles, California and 11 other locations · NCT06242470

• Assessing sexual health needs in patients with advanced cancer

  This study is trying to understand the sexual health needs of people with advanced cancer to see how it affects their quality of life and find ways to improve their care.

  Recruiting at 3 sites Hospices Civils de Lyon · Lyon and 2 other locations · NCT06229158

• Treatment of advanced lung cancer using KB707

  This study is testing a new treatment called KB707 to see if it can help adults with advanced lung cancer by boosting their immune response, especially for those who haven't had success with standard therapies.

  Recruiting at 10 sites Phase 1/2 Krystal Biotech, Inc. · Dothan, Alabama and 13 other locations · NCT06228326

• Analyzing blood and tumor markers to predict response to immunotherapy in advanced cancer

  This study is testing if blood and tumor markers can help predict how well people with advanced cancer will respond to immunotherapy treatments.

  Recruiting Gene Solutions · Ho Chi Minh City, Hồ Chí Minh and 1 other locations · NCT06227728

• CD70-targeted CAR-T treatment for advanced gynecologic cancer

  This study is testing a new CAR-T treatment that targets CD70 to see if it can help people with advanced gynecologic cancers feel better and improve their outcomes.

  Recruiting Phase 1 Chongqing Precision Biotech Co., Ltd · Wuhu, Anhui · NCT06215950

• Assessing Trastuzumab Deruxtecan in Chinese Patients with HER2-positive and HER2-low Breast Cancer

  This study is testing how well Trastuzumab Deruxtecan works for Chinese patients with advanced HER2-positive or HER2-low breast cancer who have already tried other treatments.

  Recruiting at 46 sites Daiichi Sankyo · Beijing and 53 other locations · NCT06210776

• Psilocybin-assisted therapy for anxiety and depression in advanced cancer patients

  This study is testing if therapy combined with psilocybin can help advanced cancer patients who are feeling anxious or depressed feel better and improve their quality of life.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT06200155

• Testing PTX-912 in patients with advanced solid tumors

  This study is testing a new drug called PTX-912 to see if it is safe and effective for people with advanced solid tumors.

  Recruiting at 3 sites Phase 1 Proviva Therapeutics, Inc. · Duarte, California and 2 other locations · NCT06190886

• Evaluating TQB2922 injection for patients with advanced cancers

  This study is testing a new injectable treatment called TQB2922 to see if it can help adults with advanced cancers who have run out of other options.

  Recruiting Phase 1 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Chongqing, Chongqing Municipality and 16 other locations · NCT06188624

• Continued access to treatment for patients with advanced cancer

  This study is testing if patients with advanced cancer who have benefited from previous treatments can safely continue receiving a specific drug to see if it helps them longer.

  Recruiting Phase 3 Daiichi Sankyo · Miami, Florida and 33 other locations · NCT06174987

• Integrated Smartphone Tool to Help Manage Malignant Pain

  A smartphone app called I-STAMP is being tested to help adults with advanced cancer see if it can better manage their pain and track their medications.

  Recruiting Dana-Farber Cancer Institute · Boston, Massachusetts · NCT06117709

• Testing AWT020 for advanced cancer treatment

  This study is testing a new drug called AWT020 to see if it can help people with advanced cancer who haven't had success with other treatments.

  Recruiting at 4 sites Phase 1 Anwita Biosciences · South Brisbane, Queensland and 3 other locations · NCT06092580

• Evaluating disparities in precision oncology for metastatic cancer patients

  This study looks at how different social factors affect the treatment and outcomes for people with metastatic cancer to help understand why some patients do better than others.

  Recruiting Indiana University · Indianapolis, Indiana · NCT06081517

• Evaluating CJRB-101 with Pembrolizumab for Advanced Cancer

  This study is testing a new treatment combining CJRB-101 with pembrolizumab to see if it helps people with advanced cancers like lung cancer and melanoma feel better and respond better to their treatment.

  Recruiting at 4 sites Phase 1/2 CJ Bioscience, Inc. · Irvine, California and 3 other locations · NCT05877430

• MQ710 with or without pembrolizumab for advanced skin and other solid tumors

  This will test different doses of MQ710, alone or together with pembrolizumab, in adults with advanced or recurrent solid tumors (including skin cancers) to find a safe dose with mild side effects.

  Recruiting at 5 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT05859074

• Evaluating INX-315 for advanced cancer treatment

  This study is testing a new oral medication called INX-315 to see if it can safely help people with advanced cancers, including breast and ovarian cancer, who haven't responded to other treatments.

  Recruiting at 17 sites Phase 1/2 Incyclix Bio · Orlando, Florida and 17 other locations · NCT05735080

• Combination treatment for advanced clear cell kidney cancer

  This study is testing a new combination of treatments for people with advanced clear cell kidney cancer to see if it is safe and effective.

  Recruiting Phase 1/2 M.D. Anderson Cancer Center · Houston, Texas · NCT05663710

• Psilocybin therapy for anxiety and depression in advanced cancer patients

  This study is testing if a single dose of psilocybin can help reduce anxiety and depression in patients with advanced cancer when combined with therapy.

  Recruiting at 2 sites Phase 2/3 NYU Langone Health · Aurora, Colorado and 1 other locations · NCT05398484

• New treatment for advanced solid tumors using Q901 and pembrolizumab

  This study is testing a new drug called Q901, alone or with pembrolizumab, to see if it can safely help people with advanced solid tumors.

  Recruiting at 14 sites Phase 1/2 Qurient Co., Ltd. · Phoenix, Arizona and 13 other locations · NCT05394103

• Testing BIO-106 with pembrolizumab in patients with advanced cancers

  This study is testing a new treatment called BIO-106, both alone and with pembrolizumab, to see if it can help people with advanced cancers that haven't responded to other therapies.

  Recruiting at 3 sites Phase 1/2 BiOneCure Therapeutics Inc. · Austin, Texas and 2 other locations · NCT05320588

• Testing IMC-002 in patients with advanced cancer who have not responded to standard treatments

  This study is testing a new treatment called IMC-002 in patients with advanced cancer who haven't had success with regular therapies to see if it can help them.

  Recruiting Phase 1 ImmuneOncia Therapeutics Inc. · Goyang-si and 2 other locations · NCT05276310

• Testing RBS2418 for advanced metastatic solid tumors

  This study is testing a new treatment called RBS2418 for people with advanced solid tumors to see if it can help them feel better, both on its own and when combined with another medication.

  Recruiting at 12 sites Phase 1 Riboscience, LLC. · Scottsdale, Arizona and 13 other locations · NCT05270213

• CVM-1118 combined with Nivolumab for advanced liver cancer

  This study is testing if a new cancer drug called CVM-1118, when combined with Nivolumab, can help people with advanced liver cancer who haven't had success with other treatments.

  Recruiting at 5 sites Phase 2 TaiRx, Inc. · Kaohsiung City and 4 other locations · NCT05257590

• Treatment of advanced cancer using a targeted radioactive antibody

  This study is testing a new radioactive treatment for advanced colorectal cancer to see how safe it is and what the best dose is for patients.

  Recruiting Phase 1 City of Hope Medical Center · Duarte, California · NCT05204147

• Consultation to reduce medication side effects using genetic information

  This study is testing if a personalized clinic can help adults taking multiple medications by using their genetic information to reduce side effects and improve how their medicines work.

  Recruiting University of Chicago · Chicago, Illinois · NCT05166694

• Facilitating access to targeted anti-cancer drugs for advanced cancer patients

  This study is testing whether targeted anti-cancer drugs can help patients with advanced cancer who have specific genetic markers, while also making it easier for them to access these treatments.

  Recruiting at 5 sites Phase 2 Helsinki University Central Hospital · Turku, Southwest Finland and 4 other locations · NCT05159245

• Oncolytic virus treatment combined with nivolumab for advanced solid tumors

  This study is testing a new virus treatment combined with an existing cancer drug to see if it can help people with advanced solid tumors, like lung cancer, whose cancer has not improved with previous treatments.

  Recruiting Phase 1 Memgen, Inc. · Tampa, Florida and 1 other locations · NCT05076760

• Testing repotrectinib with chemotherapy for children and young adults with advanced solid tumors

  This study is testing if the drug repotrectinib, when combined with chemotherapy, can help children and young adults with advanced solid tumors feel better and improve their treatment outcomes.

  Recruiting Phase 1/2 Memorial Sloan Kettering Cancer Center · New York, New York · NCT05004116

• Evaluating TJ033721 for advanced or metastatic solid tumors

  This study is testing a new drug called TJ033721 to see if it can help people with advanced or metastatic solid tumors, both on its own and in combination with other treatments.

  Recruiting at 7 sites Phase 1 I-Mab Biopharma US Limited · Orange, California and 20 other locations · NCT04900818

• Treatment of advanced or metastatic solid tumors with ART0380

  This study is testing a new drug called ART0380 to see if it can safely help people with advanced solid tumors that have specific DNA repair issues, either on its own or with other chemotherapy drugs.

  Recruiting at 62 sites Phase 1/2 Artios Pharma Ltd · Birmingham, Alabama and 87 other locations · NCT04657068

• Observing cancer outcomes in patients receiving integrative oncology care

  This study is testing how well combining naturopathic medicine with regular cancer treatments helps early-stage and advanced-stage cancer patients live longer and stay healthy.

  Recruiting Advanced Integrative Medical Science Institute · Seattle, Washington · NCT04495790

• Evaluating the needs of people living with incurable cancer

  This study is trying to understand the needs and experiences of people living with incurable cancer to help improve their care and treatment options.

  Recruiting University of Edinburgh · Edinburgh · NCT04406662

• T cell therapy targeting KRAS G12V mutation for advanced pancreatic cancer

  This study is testing a new T cell therapy that uses patients' own immune cells to target a specific mutation in advanced pancreatic cancer to see if it can help them fight the disease.

  Recruiting Phase 1/2 Changhai Hospital · Shanghai · NCT04146298

• Comparing preoperative chemotherapy alone to chemotherapy with radiotherapy for rectal cancer

  This study is testing whether chemotherapy alone before surgery is just as effective as chemotherapy combined with radiation for people with locally advanced rectal cancer.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Le Kremlin-Bicêtre, Île-de-France Region · NCT03875781

• Evaluating NUC-7738 for advanced solid tumors and lymphoma

  This study is testing a new treatment called NUC-7738, alone or with another drug, to see if it helps people with advanced solid tumors and lymphoma, especially those who haven't responded to other therapies.

  Recruiting at 9 sites Phase 1/2 NuCana plc · Cambridge and 8 other locations · NCT03829254

• Using toripalimab for advanced solid tumors with specific genetic mutations

  This study is testing if toripalimab can help people with advanced solid tumors that have certain genetic mutations feel better and live longer.

  Recruiting at 4 sites Phase 2 Sun Yat-sen University · Guangzhou, Guangdong and 3 other locations · NCT03810339

• Molecular Tumor Board for advanced cancer patients

  This study looks at how well the advice from a special team of doctors helps advanced cancer patients live longer and feel better in their everyday lives.

  Recruiting University Hospital Tuebingen · Tübingen, Baden-Wurttemberg · NCT03503149

• Treatment of advanced solid tumors with APL-101 for specific genetic mutations

  This study is testing a new oral medication called APL-101 to see if it helps people with advanced lung cancer and other solid tumors that have certain genetic changes, especially those who haven't had success with standard treatments.

  Recruiting at 32 sites Phase 2 Apollomics Inc. · Los Angeles, California and 34 other locations · NCT03175224

• Examining pain sensitivity in cancer therapy patients

  This study is testing how cancer treatment affects pain sensitivity in patients by comparing their responses to different sensations with those of healthy individuals.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT00515060

NIH-funded research (newest 40 of 64)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Meaning-Centered Psychotherapy for Mexican Patients with Advanced Cancer

  A cancer center in Mexico will test a culturally adapted therapy to help Mexican patients with advanced cancer find meaning, peace, and purpose at the end of life.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11575359

• Geriatric assessments to guide cancer care for older adults with advanced cancer

  A study tests a geriatric assessment–based approach to tailor cancer treatment in older adults with advanced cancer to reduce side effects and keep patients at home longer.

  NIH research University of Rochester · Rochester, United States · NIH-11452992

• Healing Gardens: a mobile game-based program to help adults with advanced cancer manage pain

  A patient-friendly program uses a playful, phone-based game and coping tools to help adults with advanced cancer reduce pain and use medicines and strategies more effectively.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11444947

• Brief Meaning Centered Psychotherapy for Advanced Cancer Patients Receiving Homecare

  A practical study tests a short, meaning-centered talk therapy delivered by home health nurses to reduce distress in people with advanced cancer who get home care.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11427905

• Helping Advanced Cancer Patients and Families Plan Ahead with a Resilience-Building Web Program

  A web-based resilience program is being tested to help people with advanced cancer and their family caregivers have meaningful conversations and complete advance directives.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11417326

• Web program to help people with advanced cancer and their caregivers talk about future medical wishes

  This project tries a web-based resilience program to help adults with advanced cancer and their family caregivers talk about future care and complete advance directives.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11411651

• Paths to resilience through social networks for older adults with advanced cancer

  This grant looks at how the people and relationships around older adults with advanced cancer help shape their health choices and use of care near the end of life.

  NIH research University of Rochester · Rochester, United States · NIH-11405491

• Meaning-Centered Psychotherapy for Mexican patients with advanced cancer

  A new therapy called Meaning-Centered Psychotherapy is tested for Mexican adults with advanced cancer to help them cope with mortality, uncertainty, and spiritual concerns.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11404409

• Survivors living with advanced cancer after durable response to immune therapy

  This grant follows people who had advanced cancer and responded well to immune checkpoint inhibitors to understand what helps them stay well and how their symptoms change over time.

  NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-11401364

• Meaning-centered psychotherapy for Mexican patients with advanced cancer

  This project offers a Spanish-language meaning-centered psychotherapy program to help Mexican people with advanced cancer cope with depression, anxiety, and worries about mortality while finding peace and purpose.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11399205

• Core Lab for Advanced Cancer Image Analysis (advanced medical imaging support)

  This NIH grant helps a renowned imaging core at UW provide advanced image analysis support for cancer imaging projects to improve how tumors are studied in clinical trials.

  NIH research University of Washington · Seattle, United States · NIH-11398160

• Psycho-Spiritual Support for Patients with Advanced Cancer and Their Family Caregivers

  A program tests a four-session, family-focused meditation delivered by video to help people with advanced cancer and their caregivers feel less depressive and spiritually distressed.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11397692

• Telemedicine and mobile health support to ease symptoms for advanced cancer patients in rural areas

  A short, patient-friendly trial tests a four-module telemedicine-mHealth program designed to help people with advanced cancer who live in rural communities feel better and sleep more soundly.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11391236

• Caregivers and Patients Support for Advanced Cancer

  A doctor-in-training is developing a telehealth five-session program to help patients with advanced cancer and their caregivers manage their psychosocial needs and quality of life.

  NIH research Ponce School of Medicine · Ponce, United States · NIH-11389358

• BOLSTER: Strengthening Care for Advanced Cancer Patients and Their Caregivers

  A multi-site trial tests a bundled, patient- and caregiver-centered palliative care program to improve quality of life and reduce hospital visits for people with advanced solid tumors.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11389158

• Novel behavioral therapy to ease fear of cancer progression in advanced cancer patients

  A randomized trial tests a new behavior-based approach to reduce fear and distress in adults with advanced cancer who are living with uncertainty about their disease.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11379002

• Interactive visual aid to support stopping cancer treatment decisions in advanced cancer

  A mentored clinician-researcher will develop and test an interactive visual tool to help patients with advanced cancer, their caregivers, and clinicians communicate about stopping treatment in a way that respects patient values and reduces uncertainty.

  NIH research Dartmouth-Hitchcock Clinic · Lebanon, United States · NIH-11371154

• Engage: Telehealth psychosocial support to reduce symptom interference in advanced cancer

  A proven, doctor-guided telehealth program helps people with advanced cancer cope with pain, fatigue, and distress so these symptoms interfere less with daily life.

  NIH research Duke University · Durham, United States · NIH-11369638

• Self-System Therapy to help older adults with advanced cancer feel less distressed and live better, delivered by telehealth

  A telehealth program tests a therapy designed to help adults 60 and older living with advanced cancer feel less distress and improve emotion regulation and quality of life.

  NIH research Duke University · Durham, United States · NIH-11365683

• Psilocybin-assisted therapy for distress in advanced cancer

  This grant tests whether psilocybin-assisted therapy can reduce anxiety, depression, and existential distress in people with advanced cancer.

  NIH research New York University School of Medicine · New York, United States · NIH-11348885

• 3D Slicer: Open-source software to boost cancer imaging research

  An open-source imaging software platform is being modernized and tested on brain cancer data to help researchers develop faster, safer cancer imaging tools.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11343589

• Virtual AI-Assisted Music Therapy for Anxiety in Advanced Cancer

  A new AI-enabled music therapy program for people with advanced cancer aims to reduce anxiety and improve quality of life.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11296984

• Understanding symptoms in children with advanced cancer to guide care

  A study to map how symptoms change over time in kids with advanced cancer and use that to tailor better, more proactive symptom care.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11272464

• Using patient-reported health updates to improve palliative care for older adults with advanced cancer

  A study tests whether electronic patient-reported outcomes (ePRO) can help doctors deliver timely palliative care to older adults with advanced cancer.

  NIH research Dartmouth-Hitchcock Clinic · Lebanon, United States · NIH-11265892

• Algorithm-Enabled Patient Engagement to Clarify Goals of Care for Veterans with Advanced Cancer

  A VA study will use an algorithm to flag veterans with advanced cancer and connect them with trained lay health workers to discuss goals of care with their oncology team.

  NIH research Veterans Admin Palo Alto Health Care Sys · Palo Alto, United States · NIH-11241948

• Using machine learning to help doctors make better decisions for advanced cancer patients

  This study is working on a new way to help doctors better predict how long patients with advanced cancer might live, using smart computer tools alongside their medical expertise, so that patients can get the right care and support when they need it most.

  NIH research Emory University · Atlanta, United States · NIH-11239355

• Using mobile health technology to help advanced cancer patients manage chronic pain

  This study is testing a new smartphone app that helps people with advanced cancer manage their pain better by using techniques from therapy, making it easier for them to get support without needing to go to appointments.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11236544

• How social connections shape care choices for older adults with advanced cancer

  This project looks at how the people in an older adult's life and the quality of those relationships affect having serious illness conversations, completing advance care plans, and using palliative care.

  NIH research University of Rochester · Rochester, United States · NIH-11193926

• Telehealth and mobile program to ease sleep, worry, depression, and fatigue for people with advanced cancer in rural areas

  A short telehealth and mobile program aims to help people with advanced cancer in rural communities manage sleep problems, worry/anxiety, depression, and fatigue.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11180332

• A video game to help women with metastatic breast or advanced gynecologic cancer speak up for their care

  An interactive, multi-session video game teaches adult women with metastatic breast or advanced gynecologic cancer practical self-advocacy skills to manage symptoms and get care that matches their priorities.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11171425

• Psychospiritual support for people with advanced cancer and their family caregivers

  A four-session family-focused meditation program delivered by videoconference aims to help people with advanced cancer and their family caregivers cope with depression and spiritual distress.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11168810

• Survivorship after lasting benefit from immunotherapy for advanced cancer

  This project follows people with advanced cancers who have had long-lasting benefit from immunotherapy to track their health, symptoms, and care needs over time.

  NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-11168670

• Meaning-centered psychotherapy for Mexican people with advanced cancer

  A culturally adapted meaning-centered therapy offered to Mexican patients with advanced cancer to ease depression, anxiety, and worries about the future.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11158861

• Engage: A Telehealth Program to Help Patients with Advanced Cancer Manage Symptoms

  This program offers a telehealth-delivered approach to help patients with advanced cancer better manage symptoms like pain, fatigue, and distress that interfere with their daily lives.

  NIH research Duke University · Durham, United States · NIH-11158704

• Improving Care for Advanced Cancer Using Smart Technology

  This project helps doctors better understand the future health of advanced cancer patients by combining their expertise with smart computer programs, aiming for earlier and better care planning.

  NIH research Emory University · Atlanta, United States · NIH-11123903

• Psilocybin to Help with Emotional Challenges from Advanced Cancer

  This project is exploring if psilocybin can help people with advanced cancer feel better emotionally and improve their quality of life.

  NIH research New York University School of Medicine · New York, United States · NIH-11123369

• Helping Families Support Loved Ones with Advanced Cancer in Making Health Decisions

  This project offers a program to teach family caregivers of people with advanced cancer how to best support their loved ones when making important health choices.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11112423

• Improving end-of-life care for children with cancer

  This study is all about making end-of-life care better for kids with advanced cancer by listening to what families need and want, and it will create a new questionnaire to help improve the care they receive.

  NIH research Yale University · New Haven, United States · NIH-11045093

• Early palliative support by trained lay coaches for caregivers of people with advanced cancer

  This program offers early palliative support from trained lay coaches to help under-resourced family and friend caregivers of people newly diagnosed with advanced cancer.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11044561

• Understanding and managing advanced cancer pain at home using smart technology

  This study is looking at how people with advanced cancer and their family caregivers manage pain at home, and it wants to use smart technology to create personalized support that makes pain relief easier and more effective for everyone involved.

  NIH research University of Virginia · Charlottesville, United States · NIH-10992612

Related topics

Quick answers

How many Advanced Cancer clinical trials are recruiting right now?

82, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (49 trials), China (16 trials), Australia (7 trials), Canada (6 trials), France (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 21, Phase 1/2: 14, Phase 2: 9, Phase 3: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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