Condition

Celiac Disease clinical trials and research

• 31Clinical trials
• 30NIH research projects
• 1New in 30 days
• 16Countries

Newest Celiac Disease clinical trials

All recruiting trials (31)

• Mediterranean diet and processed food in adults with celiac disease on a gluten-free diet

  This observational study looks at whether following a Mediterranean-style diet or eating more highly processed foods affects GI symptoms and quality of life in adults with celiac disease who have been on a strict gluten-free diet.

  Recruiting at 7 sites Istituti Clinici Scientifici Maugeri SpA · Brescia, BS and 6 other locations · NCT07915063

• Exercise for Metabolic Syndrome and Fatty Liver in Adolescent Girls with Celiac Disease

  This study tests whether a 3-month walking program helps improve metabolic syndrome and fatty liver in adolescent females with celiac disease.

  Recruiting Cairo University · Giza, Dokki · NCT07832994

• Nutrition and physical activity education for children with celiac disease

  This study tests whether a combined nutrition and physical activity education program helps 8- to 12-year-olds with celiac disease improve body health, eating habits, activity, and quality of life while on a gluten-free diet.

  Recruiting Bahçeşehir University · Istanbul, Besiktas · NCT07750795

• Liver Fat and Scarring in People Suspected of Non-Celiac Wheat Sensitivity

  This study looks to see if people with non-celiac wheat sensitivity have liver fat or fibrosis and how this relates to IBS/FD and celiac disease.

  Recruiting at 2 sites University of Palermo · Palermo, Palermo and 1 other locations · NCT07750535

• Omega-3 fats to reduce inflammation in adults with newly diagnosed celiac disease

  This study tests whether adding omega-3 fatty acid supplements to a gluten-free plan helps reduce inflammation and promote intestinal healing in adults who have just been diagnosed with celiac disease.

  Recruiting University of Chile · Santiago, Metropolitan Region · NCT07585669

• Wheat sensitivity or IBS/functional dyspepsia in relatives of people with celiac disease

  This project will test whether adults related to celiac patients have higher rates of non-celiac wheat sensitivity or IBS/functional dyspepsia and whether symptoms change on a wheat-free diet.

  Recruiting at 2 sites University of Palermo · Palermo, PA and 1 other locations · NCT07584473

• Histology and molecular profiling of small-bowel biopsies to improve celiac care

  This project will test whether digital imaging, AI, gene-level profiling, and lab-grown intestinal cells can help diagnose and understand celiac disease and related small-bowel problems in adults having a gastroscopy.

  Recruiting at 3 sites Tampere University Hospital · Tampere and 2 other locations · NCT07556328

• AI system to detect and describe small-bowel mucosal damage in celiac and other enteropathies

  This project will test if an artificial intelligence system can find and describe small-bowel mucosal atrophy and other lesions in adults having small-bowel endoscopy or capsule endoscopy.

  Recruiting Istituti Clinici Scientifici Maugeri SpA · Pavia, PV · NCT07387185

• First-in-patient safety test of HB-2121 for celiac disease diagnosis

  This test gives a single oral dose of HB-2121 to adults having an EGD for suspected celiac disease to see if it is safe and how it interacts with the small intestine.

  Recruiting Phase 1 Stanford University · Stanford, California · NCT07377565

• Children's immune response to small amounts of gluten

  This study tests whether giving small, controlled amounts of gluten to children with celiac disease causes measurable changes in their immune cells.

  Recruiting Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud · Málaga · NCT07362654

• ZED1227 for people with ongoing celiac symptoms despite a gluten-free diet

  This trial will test whether ZED1227 can reduce persistent celiac disease symptoms in adults who still have problems despite following a gluten-free diet.

  Recruiting Phase 2 Dr. Falk Pharma GmbH · Mainz · NCT07298343

• DONQ52 to reduce intestinal damage from gluten in celiac disease

  This study will try DONQ52 in people with celiac disease on a gluten-free diet to see if it reduces small intestinal damage and symptoms after simulated inadvertent gluten exposure.

  Recruiting at 74 sites Phase 2 Chugai Pharmaceutical · Anniston, Alabama and 73 other locations · NCT07239336

• Natural history and clinical features of celiac disease and related non-celiac enteropathies

  This registry collects medical, genetic, and test information from people diagnosed with celiac disease or having tests for it to learn how the condition develops and is treated.

  Recruiting Hospital Mutua de Terrassa · Terrassa, Barcelona · NCT07070596

• Hydroxyapatite home treatment for sensitive teeth in people with celiac disease

  The trial will see if adding a nightly hydroxyapatite mousse to regular hydroxyapatite toothpaste reduces tooth sensitivity in adults with celiac disease and enamel demineralization.

  Recruiting University of Pavia · Pavia, Lombardy · NCT07069127

• Does a gluten shake or a gluten cookie produce a stronger immune response in celiac disease?

  This trial tests whether a liquid gluten shake or a solid gluten cookie causes a bigger IL-2 immune response in adults with celiac disease who have been on a gluten-free diet.

  Recruiting at 2 sites Oslo University Hospital · Oslo, Oslo and 1 other locations · NCT07039773

• FB102 versus placebo for adults with celiac disease after a gluten challenge

  This will test whether taking FB102 can prevent symptoms and immune reactions in adults with well-controlled celiac disease after a planned small gluten challenge.

  Recruiting Phase 2 Forte Biosciences, Inc. · Melbourne · NCT06982963

• Using urine samples to diagnose gastrointestinal diseases

  This study is testing a new way to use urine samples to see if it can help diagnose different gastrointestinal diseases like colorectal cancer and Crohn's disease.

  Recruiting at 4 sites Luventix, Inc. · Encinitas, California and 3 other locations · NCT06710067

• Investigating persistent villous atrophy in celiac disease patients on a strict gluten-free diet

  This study is trying to find out why some people with celiac disease still have gut problems even after sticking to a strict gluten-free diet for two years.

  Recruiting Hospital Mutua de Terrassa · Terrassa, Barcelona · NCT06500754

• Improving capsule endoscopy diagnostics with artificial intelligence

  This study is testing whether using artificial intelligence can help doctors read capsule endoscopy images more accurately and quickly for patients getting this routine procedure.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06152289

• Using gluten detection technology and telemedicine to manage celiac disease

  This study is testing if new gluten detection tools used with online support from dietitians can help newly diagnosed adults with celiac disease manage their condition better and improve their quality of life.

  Recruiting at 4 sites Columbia University · Chicago, Illinois and 3 other locations · NCT06059716

• A no-biopsy method for diagnosing celiac disease using antibody tests

  This study is testing a new way to diagnose celiac disease using blood tests instead of needing a biopsy, and it's for both kids and adults who are newly diagnosed.

  Recruiting at 6 sites Instituto de Investigación Hospital Universitario La Paz · Terrassa, Barcelona and 5 other locations · NCT05983978

• Nationwide registry for systemic autoimmune and autoinflammatory diseases in Armenia

  This study is trying to gather information about systemic autoimmune and autoinflammatory diseases in Armenia to better understand how these conditions progress and how they are treated.

  Recruiting at 4 sites Santé Arménie French-Armenian Research Center · Yerevan and 5 other locations · NCT05904301

• Improving blood sugar and reducing inflammation through diet changes.

  This study is testing whether a gluten-free diet and probiotics can help improve blood sugar levels and reduce inflammation in healthy people, including those with and without diabetes.

  Recruiting Göteborg University · Gothenburg and 1 other locations · NCT05894746

• Understanding tissue damage and healing in celiac disease

  This study is trying to understand how gluten and other factors affect tissue damage and healing in people with celiac disease, comparing those on a gluten-free diet to those who still eat gluten.

  Recruiting at 2 sites University of Chicago · Pasadena, California and 2 other locations · NCT05680012

• Investigating different types of coeliac disease

  This study is trying to understand the different types of coeliac disease and dermatitis herpetiformis by looking at genetic and immune differences in patients and healthy people to help improve treatment options.

  Recruiting Tampere University Hospital · Tampere · NCT05597904

• L-tryptophan supplementation for celiac disease symptoms

  This study is testing if taking L-tryptophan can help people with celiac disease who still have symptoms after a year on a gluten-free diet feel better.

  Recruiting McMaster University · Hamilton, Ontario · NCT05576038

• A platform for collecting health data on ME/CFS and Long Covid

  This study is trying to collect health information from adults with ME/CFS and Long Covid to help researchers better understand these conditions and improve future treatments.

  Recruiting Brain Inflammation Collaborative · Delafield, Wisconsin · NCT04806620

• Screening children for Type 1 Diabetes and Celiac Disease risk during routine healthcare visits

  This study is testing whether screening young children for signs of Type 1 Diabetes and celiac disease during regular doctor visits can help catch these conditions early and improve their health.

  Recruiting at 4 sites Sanford Health · Bemidji, Minnesota and 3 other locations · NCT04477928

• Investigating immune-related intestinal diseases in adults

  This study looks at how certain immune-related gut diseases in adults affect the balance of cells in the intestines and liver to see if it can lead to serious complications.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Créteil and 3 other locations · NCT04280510

• Using fecal microbiota transplantation to treat gut disorders

  This study is testing whether a treatment that involves using healthy stool to help restore gut bacteria can improve symptoms for people with gut disorders like Crohn's disease and irritable bowel syndrome.

  Recruiting Chinese University of Hong Kong · Hong Kong, Shatin · NCT04014413

• Study of factors influencing celiac disease in infants

  This study is trying to see how genetics and environmental factors affect the risk of celiac disease in infants who have a family member with the condition.

  Recruiting at 2 sites Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT02061306

NIH-funded research (30)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how immune cells interact in celiac disease to guide healing

  A study from the University of Chicago will follow people with celiac disease to understand how immune cells in the gut contribute to damage or healing when gluten is present or restricted.

  NIH research University of Chicago · Chicago, United States · NIH-11465673

• NanoDiscs: a new way to calm the immune system in celiac disease

  A new, protein-like particle called NanoDiscs is being developed to deliver safe targets to the immune system in people with celiac disease, with the goal of reducing reactions to gluten.

  NIH research Evoq Therapeutics, INC. · Ann Arbor, United States · NIH-11418898

• Tissue damage and healing in Celiac Disease

  A broad study at the University of Chicago is exploring why some people with celiac disease keep having symptoms and tissue damage even when they try to follow a gluten-free diet.

  NIH research University of Chicago · Chicago, United States · NIH-11392285

• Gluten-detection devices and telemedicine to help adults with celiac disease

  This project looks at whether using portable gluten sensors and urine gluten tests together with telemedicine can help adults with celiac disease stick to a gluten-free diet and feel better.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11370961

• Gluten-sensing tech to help manage celiac disease with telemedicine

  A study tests new gluten-detection tools used with online care to help adults with celiac disease manage their condition.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11370183

• Role of Transglutaminase 2 in Celiac Disease

  A study from Stanford aims to understand how a specific enzyme, TG2, contributes to celiac disease and to test a potential gut-focused treatment that could one day help people avoid dietary controls.

  NIH research Stanford University · Stanford, United States · NIH-11365566

• Gluten-specific immune responses in a humanized mouse model of celiac disease

  A study in a special mouse that carries human immune system pieces to understand how gluten triggers celiac disease and to test potential therapies.

  NIH research Yale University · New Haven, United States · NIH-11350112

• Celiac disease: finding blood and tissue clues to gut inflammation

  A study at Yale will look for immune clues in blood and gut tissue to understand how celiac disease causes damage and how we might monitor it without invasive tests.

  NIH research Yale University · New Haven, United States · NIH-11350111

• Pathobiology of the intestinal lining in celiac disease

  A research team at Yale is studying how the lining of the small intestine is damaged in people with celiac disease, with the goal of improving understanding and treatment.

  NIH research Yale University · New Haven, United States · NIH-11350110

• Celiac Disease: How the immune system reacts to gluten and ways to measure disease activity

  A large NIH project is exploring why some people with the genetic risk for celiac disease develop active disease and how to measure it so doctors can treat it better.

  NIH research Yale University · New Haven, United States · NIH-11350106

• Organoid model of tissue-resident immunity in celiac disease

  A patient-friendly look at a project that creates tiny, patient-derived gut models with their immune cells to study how gluten triggers celiac disease.

  NIH research Stanford University · Stanford, United States · NIH-11344700

• Gut microbes and immune signals that lead children at risk to develop celiac disease

  This project looks at whether differences in gut microbes and a child's immune and genetic markers help explain which children with celiac risk go on to develop celiac disease.

  NIH research Washington University · Saint Louis, United States · NIH-11327416

• How gut bacteria and the gut lining interact in celiac disease

  This project looks at how specific gut microbes and the substances they make affect the gut lining and immune system in people with or at high risk for celiac disease.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11324586

• Gut protists and celiac disease

  Looking at whether tiny single-celled organisms in the gut change how people with celiac disease react to gluten.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11285168

• Celiac disease: why the gut gets damaged and how it heals

  Researchers are looking at why some people with celiac disease still have gut damage and symptoms despite a gluten-free diet, to help patients who don't fully recover.

  NIH research University of Chicago · Chicago, United States · NIH-11159754

• Understanding Transglutaminase 2's Role in Celiac Disease

  This work explores how a specific enzyme, Transglutaminase 2 (TG2), contributes to celiac disease in patients.

  NIH research Stanford University · Stanford, United States · NIH-11145816

• How B cells and T cells interact in celiac disease

  Researchers are exploring how B cells and T cells communicate in people with celiac disease to find new treatments that do not rely only on a gluten-free diet.

  NIH research University of Chicago · Chicago, United States · NIH-11129868

• New Ways to Manage Celiac Disease

  This project helps adults with celiac disease manage their gluten-free diet better using new technologies and telemedicine.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11117054

• Understanding the role of gut bacteria in Celiac Disease

  This study is looking at how the bacteria in your gut might affect your immune system and the lining of your intestines if you have or are at risk for Celiac Disease, to better understand what role these bacteria play in the disease.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11116924

• Investigating factors that lead to celiac disease in children

  This study is looking at how certain germs in the gut and genetic factors affect the development of celiac disease in kids who might be at risk, and it aims to help find ways to prevent the disease and better support those who have it.

  NIH research Washington University · Saint Louis, United States · NIH-11114008

• Investigating how gut protists affect celiac disease

  This study is looking at how tiny organisms in the gut might affect celiac disease, which happens when the body reacts poorly to gluten, and it aims to find new ways to help people with this condition feel better by understanding how these organisms interact with the immune system.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11005737

• Finding new ways to improve immunotherapy for celiac disease.

  This study is looking for new ways to help people with celiac disease by finding better treatments that work with the immune system to make it easier for them to handle gluten in their diets.

  NIH research Qrono, INC · Pittsburgh, United States · NIH-10933263

• Improving management of celiac disease with new gluten detection technologies

  This study is exploring new ways to help adults with celiac disease manage their condition better by using handy gluten detection tools and telemedicine to make it easier for them to connect with dietitians and stay on track with their gluten-free diet.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10924061

• Improving self-management of celiac disease in teenagers

  This study is designed to help teenagers with celiac disease learn how to manage their condition better by providing them and their parents with helpful information and support through online tools and text messages.

  NIH research Children's Research Institute · Washington, United States · NIH-10918335

• Investigating factors that predict celiac disease in infants at risk

  This study is looking at how the bacteria in the gut and certain substances in the body can help predict if babies at risk for celiac disease will develop a gluten intolerance, so we can find ways to help them stay healthy and avoid problems with gluten later on.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10905694

• Understanding tissue damage and healing in Celiac Disease

  This study is looking into why some people with Celiac Disease still have symptoms and nutrient issues even when they stick to a gluten-free diet, and it aims to find ways to help them heal better by understanding the role of gut bacteria and other factors.

  NIH research University of Chicago · Chicago, United States · NIH-10893380

• Understanding how B cells and T cells interact in celiac disease

  This study is looking at how certain immune cells work together in people with celiac disease to understand why some symptoms stick around even when they avoid gluten, with the hope of finding new treatments to help improve their health.

  NIH research University of Chicago · Chicago, United States · NIH-10884309

• Understanding how a specific enzyme contributes to Celiac disease

  This study is looking at how a protein called transglutaminase 2 (TG2) works with gluten in people with Celiac disease, to help understand the immune response and find new ways to treat the condition beyond just avoiding gluten.

  NIH research Stanford University · Stanford, United States · NIH-10873135

• Investigating how gut microbiome affects the development of celiac disease in infants

  This study is looking at how the gut bacteria and other factors in babies who are at risk for celiac disease change before and after they start eating gluten, to help us understand what might trigger the disease.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10656181

• Investigating the link between gut viruses, bacteria, and celiac disease in children

  This study is looking at stool and blood samples from 900 kids to see how changes in their gut bacteria and viral infections might play a role in developing celiac disease, helping us understand what might trigger this condition.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10654800

Related topics

Quick answers

How many Celiac Disease clinical trials are recruiting right now?

31, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (8 trials), Italy (6 trials), Spain (4 trials), Australia (2 trials), Finland (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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