Omega-3 fats to reduce inflammation in adults with newly diagnosed celiac disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults 18 to 65 with newly diagnosed celiac disease, who have not yet started a gluten-free diet, will be randomized to receive either 2.4 grams per day of omega-3 fatty acids or a placebo for three months while beginning a supervised gluten-free diet. The trial will measure markers of inflammation in the blood and assess intestinal healing. This is an interventional study conducted alongside standard dietary treatment to see if omega-3s offer additional benefit. The study is led by the University of Chile with collaboration from Clínica Universidad de los Andes and is based at the University of Chile Clinical Hospital in Santiago.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients aged 18 to 65 years, Newly diagnosed with celiac disease confirmed by serology and intestinal biopsy, Not yet started gluten-free diet (GFD), Willingness to adhere to a supervised gluten-free diet during the study, Able to provide informed consent

Exclusion Criteria:

* Previous or current adherence to a gluten-free diet, Use of n-3 PUFA supplements or other dietary supplements influencing inflammation within the last 3 months, Presence of other autoimmune, inflammatory, or gastrointestinal diseases (e.g., Crohn's disease, ulcerative colitis), Pregnancy or breastfeeding, Severe chronic illnesses that may interfere with the study or outcomes (e.g., uncontrolled diabetes, cancer), Allergy or intolerance to fish oil or components of the supplement, Use of immunosuppressive or anti-inflammatory medication within the last 3 months

Where it's running

• University of Chile Clinical Hospital
  Santiago, Metropolitan Region, Chile Recruiting

Study contacts

• Study coordinator: Karla A Bascuñán, PhD
• Email: kbascunan@uchile.cl
• Phone: +56 2 9773232

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.