Organoid model of tissue-resident immunity in celiac disease
Official title: Organoid Modeling of Tissue-Resident Immunity in Celiac Disease
Funded at Stanford University · NIH-11344700 · Data updated 2026-11-12
A patient-friendly look at a project that creates tiny, patient-derived gut models with their immune cells to study how gluten triggers celiac disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $769,846 |
| NIH project number | 1R01AI198576-01 |
| Project ID | NIH-11344700 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with diagnosed celiac disease who have provided biopsy tissue for organoid creation and consented to research.
✕Less likely to help
People without celiac disease or those who cannot provide biopsy tissue would not directly benefit from this study.
What this research studies
Researchers at Stanford are growing advanced gut organoids from biopsy tissue that include both the lining of the intestine and the patient’s own immune cells. By exposing these organoids to gluten, they aim to mimic how celiac disease develops and how immune cells respond inside the gut. This approach could reveal new targets for therapies that protect the gut lining and reduce harmful immune reactions. The study builds on prior work showing that these patient-specific organoids can reproduce gluten-related pathology in a lab setting.
Why it matters
Potential benefit: If successful, this work could lead to better therapies or personalized strategies to manage or prevent gut damage in people with celiac disease.
How similar studies have gone: Early organoid models that include immune components have shown promise in resembling patient-specific disease features, supporting this approach's potential.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Kuo, Calvin J — Stanford University
- Study coordinator: Kuo, Calvin J
Related research
Other NIH-funded projects on the same topics.
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Understanding how immune cells interact in celiac disease to guide healing
A study from the University of Chicago will follow people with celiac disease to understand how immune cells in the gut contribute to damage or healing when gluten is present or restricted.
-
NanoDiscs: a new way to calm the immune system in celiac disease
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Tissue damage and healing in Celiac Disease
A broad study at the University of Chicago is exploring why some people with celiac disease keep having symptoms and tissue damage even when they try to follow a gluten-free diet.
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Gluten-detection devices and telemedicine to help adults with celiac disease
This project looks at whether using portable gluten sensors and urine gluten tests together with telemedicine can help adults with celiac disease stick to a gluten-free diet and feel better.
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A study tests new gluten-detection tools used with online care to help adults with celiac disease manage their condition.
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Role of Transglutaminase 2 in Celiac Disease
A study from Stanford aims to understand how a specific enzyme, TG2, contributes to celiac disease and to test a potential gut-focused treatment that could one day help people avoid dietary controls.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.