Understanding the role of gut bacteria in Celiac Disease
Official title: Toward parsing gut microbiota-epithelium-immune metabolic crosstalk in Celiac Disease
Funded at Massachusetts General Hospital · NIH-11116924 · Data updated 2026-11-12
This study is looking at how the bacteria in your gut might affect your immune system and the lining of your intestines if you have or are at risk for Celiac Disease, to better understand what role these bacteria play in the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 14, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $599,318 |
| NIH project number | 5R01AI184777-02 |
| Project ID | NIH-11116924 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are genetically predisposed to Celiac Disease or have early signs of the condition.
✕Less likely to help
Patients who do not have a genetic predisposition to Celiac Disease or are not experiencing any symptoms related to the condition may not benefit from this research.
What this research studies
This research investigates how gut bacteria interact with the immune system and the intestinal lining in individuals with Celiac Disease. By analyzing samples from patients at risk of developing the disease, the study aims to identify specific gut microbes that may contribute to the onset and severity of Celiac Disease. Researchers will use advanced computational models to simulate these interactions and gain insights into the underlying mechanisms of the disease. This approach could help clarify whether changes in gut bacteria are a cause or a result of the disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Celiac Disease by targeting gut microbiota.
How similar studies have gone: Previous research has shown promising results in understanding the role of gut microbiota in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Zomorrodi, Ali R — Massachusetts General Hospital
- Study coordinator: Zomorrodi, Ali R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.