Investigating factors that lead to celiac disease in children
Official title: Microbial and Host Factors in the Progression to Celiac Disease
Funded at Washington University · NIH-11114008 · Data updated 2026-11-12
This study is looking at how certain germs in the gut and genetic factors affect the development of celiac disease in kids who might be at risk, and it aims to help find ways to prevent the disease and better support those who have it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | June 12, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $762,608 |
| NIH project number | 5R01AI183261-02 |
| Project ID | NIH-11114008 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who have positive serology for celiac disease or are at risk due to genetic factors.
✕Less likely to help
Patients who are adults or those without genetic predisposition to celiac disease may not benefit from this research.
What this research studies
This research focuses on understanding how certain microbial and host factors contribute to the progression of celiac disease in genetically susceptible children. By recruiting participants with positive serology for celiac disease and those with negative serology, the study aims to explore the interactions between genetic predisposition and environmental influences, particularly the role of gut microbiota. The methodology includes advanced sequencing techniques to analyze microbial communities and their relationship with immune responses. This research could provide insights into preventing the onset of celiac disease and improving patient management.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies and management options for individuals at risk of developing celiac disease.
How similar studies have gone: Previous research has shown promise in understanding the role of microbiota in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Holtz, Lori R — Washington University
- Study coordinator: Holtz, Lori R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.