Investigating different types of coeliac disease
Genetic and Biological Background and Follow-up of Different Phenotypes of Coeliac Disease
Tampere University Hospital · NCT05597904
This study is trying to understand the different types of coeliac disease and dermatitis herpetiformis by looking at genetic and immune differences in patients and healthy people to help improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Tampere University Hospital (other) |
| Locations | 1 site (Tampere) |
| Trial ID | NCT05597904 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the genetic, serological, immunological, and microbiota differences among various phenotypes of coeliac disease and dermatitis herpetiformis. By recruiting patients with these conditions as well as healthy controls, the study will compare these factors to identify potential prognostic markers. The findings could lead to more personalized follow-up and treatment guidelines for individuals affected by coeliac disease. The research will focus on understanding the clinical heterogeneity of the disease and its implications for patient care.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with coeliac disease or dermatitis herpetiformis, as well as their healthy friends or non-related family members.
Not a fit: Patients under 18 years of age or those without a confirmed diagnosis of coeliac disease or dermatitis herpetiformis will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved personalized treatment and management strategies for patients with coeliac disease.
How similar studies have performed: While the study addresses known heterogeneity in coeliac disease, the specific approach of comparing diverse phenotypes and their prognostic markers is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cohorts 1 and 2: coeliac disease or dermatitis herpetiformis diagnosis * Cohort 3: friend or non-related family member of coeliac disease or dermatitis herpetiformis patient Exclusion Criteria: * Cohorts 1-3: Age \<18 years * Cohorts 1 and 2: coeliac disease or dermatitis herpetiformis diagnosis not confirmed * Cohort 3: coeliac disease or dermatitis herpetiformis diagnosis
Where this trial is running
Tampere
- Tampere University Hospital — Tampere, Finland (RECRUITING)
Study contacts
- Study coordinator: Teea T Salmi, Prof
- Email: teea.salmi@pshp.fi
- Phone: +358503016355
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Celiac Disease, Dermatitis Herpetiformis, coeliac disease, dermatitis herpetiformis, gluten-free diet, transglutaminase, microbiata