Celiac Disease: How the immune system reacts to gluten and ways to measure disease activity
Official title: Pathogenesis and Assessment of Activity in Celiac Disease (CeD)
Funded at Yale University · NIH-11350106 · Data updated 2026-11-12
A large NIH project is exploring why some people with the genetic risk for celiac disease develop active disease and how to measure it so doctors can treat it better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 17, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $2,334,896 |
| NIH project number | 1P01AI187003-01A1 |
| Project ID | NIH-11350106 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults and children with celiac disease or at risk due to their genetic background (HLA-DQ2/DQ8) who may participate in future biomarker and therapeutic studies.
✕Less likely to help
Some participants may not directly benefit if biomarkers or therapies are not yet ready for clinical use.
What this research studies
This program brings together researchers from Yale and four collaborating centers to study the immune processes behind celiac disease and to identify biomarkers that reflect disease activity. It uses advanced lab methods to examine how gluten-triggered immune cells interact with the gut lining and cause symptoms. The work aims to translate these findings into better tests and potential therapies in the future. Participants would contribute samples and clinical information as part of ongoing research activities.
Why it matters
Potential benefit: If successful, the project could lead to new biomarkers and therapies that improve diagnosis and treatment of celiac disease.
How similar studies have gone: Earlier work suggests that gluten-specific immune responses are central to disease activity, but precise biomarkers and therapeutic targets remain under development.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Pober, Jordan S — Yale University
- Study coordinator: Pober, Jordan S
Related research
Other NIH-funded projects on the same topics.
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Understanding how immune cells interact in celiac disease to guide healing
A study from the University of Chicago will follow people with celiac disease to understand how immune cells in the gut contribute to damage or healing when gluten is present or restricted.
-
NanoDiscs: a new way to calm the immune system in celiac disease
A new, protein-like particle called NanoDiscs is being developed to deliver safe targets to the immune system in people with celiac disease, with the goal of reducing reactions to gluten.
-
Tissue damage and healing in Celiac Disease
A broad study at the University of Chicago is exploring why some people with celiac disease keep having symptoms and tissue damage even when they try to follow a gluten-free diet.
-
Gluten-detection devices and telemedicine to help adults with celiac disease
This project looks at whether using portable gluten sensors and urine gluten tests together with telemedicine can help adults with celiac disease stick to a gluten-free diet and feel better.
-
Gluten-sensing tech to help manage celiac disease with telemedicine
A study tests new gluten-detection tools used with online care to help adults with celiac disease manage their condition.
-
Role of Transglutaminase 2 in Celiac Disease
A study from Stanford aims to understand how a specific enzyme, TG2, contributes to celiac disease and to test a potential gut-focused treatment that could one day help people avoid dietary controls.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.