Investigating the link between gut viruses, bacteria, and celiac disease in children
Official title: Gut Viral and Bacterial Associations with Celiac Disease in the TEDDY Cohort
Funded at Baylor College of Medicine · NIH-10654800 · Data updated 2026-11-12
This study is looking at stool and blood samples from 900 kids to see how changes in their gut bacteria and viral infections might play a role in developing celiac disease, helping us understand what might trigger this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 20, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $649,659 |
| NIH project number | 5R01DK124581-04 |
| Project ID | NIH-10654800 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children who are part of the TEDDY cohort and are at risk for developing celiac disease.
✕Less likely to help
Patients who do not have a family history of celiac disease or are not part of the TEDDY cohort may not benefit from this research.
What this research studies
This research examines stool and blood samples from 900 children in the TEDDY cohort to explore how changes in gut microbiome and viral infections may contribute to the development of celiac disease. By analyzing these samples over time, the study aims to identify specific viruses and bacterial profiles that are associated with the onset of autoimmunity leading to celiac disease. The research employs advanced techniques such as next-generation sequencing and serological analysis to uncover potential environmental triggers. This project builds on previous findings and seeks to clarify the relationship between gut health and celiac disease.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for celiac disease in children.
How similar studies have gone: Previous research has shown promising results in linking gut microbiome and viral infections to autoimmune diseases, but this specific approach is still being explored.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Lloyd, Richard E — Baylor College of Medicine
- Study coordinator: Lloyd, Richard E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.