Gluten-specific immune responses in a humanized mouse model of celiac disease
Official title: PROJECT 3: Testing Pathobiology and Therapeutic Development in a Humanized Celiac Disease Mouse
Funded at Yale University · NIH-11350112 · Data updated 2026-11-12
A study in a special mouse that carries human immune system pieces to understand how gluten triggers celiac disease and to test potential therapies.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | June 17, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $393,507 |
| NIH project number | 1P01AI187003-01A1 |
| Project ID | NIH-11350112 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with celiac disease or gluten-related immune responses who may benefit from future therapies tested using the model.
✕Less likely to help
Individuals without celiac disease or gluten sensitivity are unlikely to benefit from this research directly.
What this research studies
This project uses a humanized mouse model to study gluten-specific immune reactions that drive celiac disease. The researchers will examine how human T cells and gut cells interact in response to gluten, aiming to identify pathways that lead to intestinal damage. By introducing key human immune components into mice, they plan to observe allergic-like responses and test how potential therapeutic approaches might interrupt these processes. The work focuses on translating findings from a mouse model toward better treatments for people living with celiac disease.
Why it matters
Potential benefit: It could lead to new treatments that lessen or prevent gluten-triggered damage in people with celiac disease.
How similar studies have gone: Previous humanized-mile studies have shown that human-like immune responses can be captured in mice, supporting this approach as promising though still exploratory.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Flavell, Richard a — Yale University
- Study coordinator: Flavell, Richard a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.