Investigating how gut microbiome affects the development of celiac disease in infants
Prospective Multi-Omic Analysis of At-Risk infants to Model Celiac Disease Pathogenesis
This study is looking at how the gut bacteria and other factors in babies who are at risk for celiac disease change before and after they start eating gluten, to help us understand what might trigger the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10656181 on NIH RePORTER |
What this research studies
This research focuses on understanding the early stages of celiac disease (CD) in infants who are genetically predisposed. By analyzing the gut microbiome and other environmental factors before and after gluten exposure, the study aims to identify critical interactions that lead to the onset of CD. The research utilizes a unique longitudinal birth cohort to collect detailed data over time, allowing for a comprehensive multi-omic analysis. This approach seeks to uncover how changes in gut microbiome composition may influence the risk of developing CD.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants who are genetically predisposed to celiac disease and are exposed to gluten.
Not a fit: Patients who do not have a genetic predisposition to celiac disease or are not infants will likely not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early interventions that prevent the onset of celiac disease in at-risk infants.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut microbiome in autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Leonard, Maureen Michelle — Massachusetts General Hospital
- Study coordinator: Leonard, Maureen Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.