Understanding how B cells and T cells interact in celiac disease
Official title: B cell-T cell crosstalk in celiac disease
Funded at University of Chicago · NIH-10884309 · Data updated 2026-11-12
This study is looking at how certain immune cells work together in people with celiac disease to understand why some symptoms stick around even when they avoid gluten, with the hope of finding new treatments to help improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 21, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $410,442 |
| NIH project number | 5R01DK128352-04 |
| Project ID | NIH-10884309 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with celiac disease who experience ongoing symptoms despite following a gluten-free diet.
✕Less likely to help
Patients who do not have celiac disease or those who have well-controlled symptoms may not benefit from this research.
What this research studies
This research investigates the immune mechanisms involved in celiac disease, particularly focusing on the interactions between B cells and T cells. It aims to uncover how these immune cells contribute to the disease's progression and the persistent symptoms experienced by patients, even when adhering to a gluten-free diet. By studying the immune response in individuals with celiac disease, the research seeks to identify potential new therapies that could improve patient outcomes beyond dietary restrictions.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for celiac disease that alleviate symptoms and improve quality of life for patients.
How similar studies have gone: Previous research has shown promise in understanding immune interactions in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Abadie, Valerie — University of Chicago
- Study coordinator: Abadie, Valerie
Related research
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A broad study at the University of Chicago is exploring why some people with celiac disease keep having symptoms and tissue damage even when they try to follow a gluten-free diet.
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A study from Stanford aims to understand how a specific enzyme, TG2, contributes to celiac disease and to test a potential gut-focused treatment that could one day help people avoid dietary controls.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.