Tissue damage and healing in Celiac Disease
Official title: Tissue destruction and healing in Celiac Disease
Funded at University of Chicago · NIH-11392285 · Data updated 2026-11-12
A broad study at the University of Chicago is exploring why some people with celiac disease keep having symptoms and tissue damage even when they try to follow a gluten-free diet.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 15, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $2,394,224 |
| NIH project number | 5RC2DK133947-05 |
| Project ID | NIH-11392285 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults and possibly older adolescents with diagnosed celiac disease who have persistent symptoms or mucosal damage despite a gluten-free diet.
✕Less likely to help
Individuals without celiac disease or those not involved in mucosal healing or immune studies are unlikely to benefit.
What this research studies
This project aims to understand why mucosal healing in celiac disease varies among patients and how different clinical presentations relate to nutrient deficiencies and long-term complications. Researchers will study gut tissue and immune responses in people with CeD, including those with ongoing symptoms despite gluten-free eating. The team will look at microbiome and mucosal factors to uncover why some patients heal differently and how this affects bone health and cancer risk. The goal is to identify biological pathways that could lead to better management and, potentially, new treatments beyond simply avoiding gluten.
Why it matters
Potential benefit: If successful, the research could lead to new ways to predict who will heal, prevent complications, and tailor treatments for people with celiac disease.
How similar studies have gone: Prior work has connected mucosal healing and complications to immune and microbiome factors, but this project seeks deeper mechanistic insights in humans.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Jabri, Bana — University of Chicago
- Study coordinator: Jabri, Bana
Related research
Other NIH-funded projects on the same topics.
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Understanding how immune cells interact in celiac disease to guide healing
A study from the University of Chicago will follow people with celiac disease to understand how immune cells in the gut contribute to damage or healing when gluten is present or restricted.
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Gluten-detection devices and telemedicine to help adults with celiac disease
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Gluten-sensing tech to help manage celiac disease with telemedicine
A study tests new gluten-detection tools used with online care to help adults with celiac disease manage their condition.
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Role of Transglutaminase 2 in Celiac Disease
A study from Stanford aims to understand how a specific enzyme, TG2, contributes to celiac disease and to test a potential gut-focused treatment that could one day help people avoid dietary controls.
-
Gluten-specific immune responses in a humanized mouse model of celiac disease
A study in a special mouse that carries human immune system pieces to understand how gluten triggers celiac disease and to test potential therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.