Understanding tissue damage and healing in Celiac Disease
Official title: Tissue destruction and healing in Celiac Disease
Funded at University of Chicago · NIH-10893380 · Data updated 2026-11-12
This study is looking into why some people with Celiac Disease still have symptoms and nutrient issues even when they stick to a gluten-free diet, and it aims to find ways to help them heal better by understanding the role of gut bacteria and other factors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 15, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $2,298,454 |
| NIH project number | 5RC2DK133947-03 |
| Project ID | NIH-10893380 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Celiac Disease, particularly those experiencing ongoing symptoms despite following a gluten-free diet.
✕Less likely to help
Patients who do not have Celiac Disease or those who are able to maintain a strict gluten-free diet without complications may not benefit from this research.
What this research studies
This research investigates the biological mechanisms behind tissue destruction and healing in individuals with Celiac Disease, particularly those who struggle to maintain a gluten-free diet. It aims to explore why some patients experience persistent symptoms and nutrient deficiencies despite adhering to dietary guidelines. By analyzing the role of the microbiome and other factors, the study seeks to uncover the complexities of Celiac Disease and improve patient outcomes. The research involves collecting data from patients to better understand their unique clinical presentations and healing processes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for Celiac Disease, enhancing the quality of life for patients.
How similar studies have gone: Previous research has shown promise in understanding the complexities of Celiac Disease, but this study aims to address specific gaps that have not been fully explored.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Jabri, Bana — University of Chicago
- Study coordinator: Jabri, Bana
Related research
Other NIH-funded projects on the same topics.
-
Understanding how immune cells interact in celiac disease to guide healing
A study from the University of Chicago will follow people with celiac disease to understand how immune cells in the gut contribute to damage or healing when gluten is present or restricted.
-
NanoDiscs: a new way to calm the immune system in celiac disease
A new, protein-like particle called NanoDiscs is being developed to deliver safe targets to the immune system in people with celiac disease, with the goal of reducing reactions to gluten.
-
Tissue damage and healing in Celiac Disease
A broad study at the University of Chicago is exploring why some people with celiac disease keep having symptoms and tissue damage even when they try to follow a gluten-free diet.
-
Gluten-detection devices and telemedicine to help adults with celiac disease
This project looks at whether using portable gluten sensors and urine gluten tests together with telemedicine can help adults with celiac disease stick to a gluten-free diet and feel better.
-
Gluten-sensing tech to help manage celiac disease with telemedicine
A study tests new gluten-detection tools used with online care to help adults with celiac disease manage their condition.
-
Role of Transglutaminase 2 in Celiac Disease
A study from Stanford aims to understand how a specific enzyme, TG2, contributes to celiac disease and to test a potential gut-focused treatment that could one day help people avoid dietary controls.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.