Understanding how a specific enzyme contributes to Celiac disease
Official title: Localizing Pathogenically Relevant Transglutaminase 2 in Celiac Disease
Funded at Stanford University · NIH-10873135 · Data updated 2026-11-12
This study is looking at how a protein called transglutaminase 2 (TG2) works with gluten in people with Celiac disease, to help understand the immune response and find new ways to treat the condition beyond just avoiding gluten.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 7, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $337,286 |
| NIH project number | 5R01DK126487-04 |
| Project ID | NIH-10873135 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Celiac disease who are experiencing symptoms despite adhering to a gluten-free diet.
✕Less likely to help
Patients who do not have Celiac disease or those who have already developed complications from long-term gluten exposure may not benefit from this research.
What this research studies
This research investigates the role of transglutaminase 2 (TG2) in Celiac disease, a condition triggered by gluten that affects the small intestine. The study aims to identify how TG2 interacts with gluten peptides and contributes to the immune response that leads to the disease. By conducting both laboratory and animal studies, the researchers will explore the biochemical mechanisms behind TG2's activity and its involvement in forming autoantibodies. This research could provide insights into potential therapeutic targets for Celiac disease beyond dietary restrictions.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with Celiac disease, improving their quality of life.
How similar studies have gone: Previous research has shown promising results in understanding the immune mechanisms of Celiac disease, making this approach a continuation of established findings.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Khosla, Chaitan — Stanford University
- Study coordinator: Khosla, Chaitan
Related research
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A broad study at the University of Chicago is exploring why some people with celiac disease keep having symptoms and tissue damage even when they try to follow a gluten-free diet.
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This project looks at whether using portable gluten sensors and urine gluten tests together with telemedicine can help adults with celiac disease stick to a gluten-free diet and feel better.
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Gluten-sensing tech to help manage celiac disease with telemedicine
A study tests new gluten-detection tools used with online care to help adults with celiac disease manage their condition.
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Role of Transglutaminase 2 in Celiac Disease
A study from Stanford aims to understand how a specific enzyme, TG2, contributes to celiac disease and to test a potential gut-focused treatment that could one day help people avoid dietary controls.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.