Investigating heart muscle diseases and targeted treatments
Official title: A multiscale computational and experimental platform to investigate cardiomyopathies and targeted therapeutics
Funded at University of Washington · NIH-10864724 · Data updated 2026-11-12
This study is looking at how changes in certain proteins affect how well the heart muscle works in people with heart conditions like hypertrophic and dilated cardiomyopathy, with the goal of finding new ways to help improve heart function.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $135,840 |
| NIH project number | 1K99HL173646-01 |
| Project ID | NIH-10864724 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with familial hypertrophic or dilated cardiomyopathies.
✕Less likely to help
Patients with non-familial heart conditions or those without significant structural protein variations may not benefit from this research.
What this research studies
This research explores how specific changes at the protein level affect heart muscle function in conditions like hypertrophic and dilated cardiomyopathies. By combining computational models and experimental techniques, the project aims to understand the mechanics of heart muscle contraction and how these processes are disrupted in disease. The focus is on the interactions between actin and myosin proteins, which are crucial for muscle contraction. The findings could lead to new therapeutic strategies for patients with these heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from serious heart muscle diseases.
How similar studies have gone: Other research has shown promising results in understanding heart muscle diseases through similar computational and experimental approaches.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Childers, Matthew Carter — University of Washington
- Study coordinator: Childers, Matthew Carter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.