Investigating heart muscle diseases and targeted treatments
A multiscale computational and experimental platform to investigate cardiomyopathies and targeted therapeutics
This study is looking at how changes in certain proteins affect how well the heart muscle works in people with heart conditions like hypertrophic and dilated cardiomyopathy, with the goal of finding new ways to help improve heart function.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10864724 on NIH RePORTER |
What this research studies
This research explores how specific changes at the protein level affect heart muscle function in conditions like hypertrophic and dilated cardiomyopathies. By combining computational models and experimental techniques, the project aims to understand the mechanics of heart muscle contraction and how these processes are disrupted in disease. The focus is on the interactions between actin and myosin proteins, which are crucial for muscle contraction. The findings could lead to new therapeutic strategies for patients with these heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with familial hypertrophic or dilated cardiomyopathies.
Not a fit: Patients with non-familial heart conditions or those without significant structural protein variations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from serious heart muscle diseases.
How similar studies have performed: Other research has shown promising results in understanding heart muscle diseases through similar computational and experimental approaches.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Childers, Matthew Carter — University of Washington
- Study coordinator: Childers, Matthew Carter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.