Prognosis prediction for patients with cardiovascular and cerebrovascular diseases using multi-omics
Official title: Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics (PROSPECT): a National, Multicenter, Retrospective-prospective, Cohort Study
Run by First Affiliated Hospital Xi'an Jiaotong University · NCT06001073 · Data updated 2026-11-12
This study is trying to find out how different biological factors affect people with heart and brain blood vessel diseases to help doctors predict outcomes and personalize treatments for them.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 3 Years to 80 Years |
| Sex | All |
| Enrollment | 25000 (estimated) |
| Sponsor | First Affiliated Hospital Xi'an Jiaotong University Academic / other |
| Locations | 1 site (Xi'an, Shaanxi) |
| Status | Recruiting |
| Started | December 5, 2022 |
| Main results expected | June 30, 2028 |
| Study ends | December 31, 2028 |
| Registry record updated | July 12, 2024 |
| Trial ID | NCT06001073 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients diagnosed with conditions such as coronary artery disease, arrhythmias, heart valve diseases, and other specified cardiovascular and cerebrovascular diseases.
✕Probably not a fit
Patients outside the age range of 3 to 80 years, pregnant or lactating women, and those unable to provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to collect clinical and biological specimen data from patients diagnosed with various cardiovascular and cerebrovascular diseases. By employing multi-omics technology, the study seeks to uncover the underlying pathogenic mechanisms of these diseases. The ultimate goal is to develop early predictive prognostic models that can inform individualized treatment strategies for affected patients. This research addresses the significant public health challenge posed by cardiovascular diseases and aims to enhance diagnosis and treatment options.
Why it matters
Potential benefit: If successful, this study could lead to more accurate prognostic models and personalized treatment plans for patients with cardiovascular and cerebrovascular diseases.
How similar studies have gone: While the use of multi-omics in cardiovascular research is gaining traction, this specific approach to prognosis prediction remains novel and largely untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who are regularly visited and followed up in the appropriate patient; department. * All patients met at least one of the following diagnostic criteria for cardiovascular and cerebrovascular diseases: * coronary artery disease group; * arrhythmia group; * heart valve disease group; * aortic dissection group; * cardiac masses group; * myocarditis group; * hypertension group; * cardiomyopathy group; * structural heart disease group; * ischemic cerebrovascular disease group; * hemorrhagic cerebrovascular disease group; * intracranial space occupying lesion group. Exclusion Criteria: * Age \<3 years or \>80 years old; * Pregnant and lactating women; * The patient declined to provide informed consent to participate in the study; * None of the above was met, but the patient was temporarily unable to sign the informed consent form due to coma and other reasons, and no legal representative signed it instead. Depending on the patient's condition, the patient may not be able to regain consciousness and sign the informed consent form.
Where it's running
-
First Affiliated Hospital of Xian Jiantong University
Xi'an, Shaanxi, China Recruiting
Study contacts
- Principal investigator: Gouliang Li — First Affiliated Hospital Xi'an Jiaotong University
- Study coordinator: Gouliang Li
- Email: liguoliang_med@163.com
- Phone: 13759982523
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Multimodal Cardiac MRI to See How the Heart Is Working
This study tests a comprehensive MRI approach to characterize heart structure and tissue in adults with suspected or confirmed cardiovascular disease.
-
Managing multiple medications in older adults with chronic diseases
This project will see if taking many different medicines changes the health outlook of people aged 65 and older who have chronic conditions.
-
Evaluating endomyocardial biopsy and tailored treatments for pediatric inflammatory heart disease
This study is testing how a heart tissue sample and personalized treatments can help kids with inflammatory heart disease, especially those with myocarditis and heart rhythm issues.
-
Pharmacy-led intervention to improve medication adherence after hospital discharge
This study tests a pharmacy-led program to help low-income patients with multiple chronic conditions take their medications correctly after leaving the hospital.
-
Stereotactic body radiation therapy versus catheter ablation for ventricular tachycardia in structural heart disease
This trial will test whether a focused radiation treatment (SBRT) can reduce ventricular tachycardia episodes more than standard catheter ablation in people with advanced structural heart disease.
-
Using low-dose aspirin after preeclampsia to improve recovery
This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.