Investigating the role of cardiac troponin I in heart muscle diseases
Official title: Moonlighting in Mitochondria: A Non-Canonical Role for Cardiac Troponin I in Inherited Cardiomyopathies
Funded at Stanford University · NIH-10985329 · Data updated 2026-11-12
This study is looking at how changes in a protein called cardiac troponin I can lead to heart muscle diseases and aims to find new ways to help patients with these inherited conditions by improving how heart cells produce energy.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $165,672 |
| NIH project number | 1K08HL171896-01A1 |
| Project ID | NIH-10985329 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with inherited cardiomyopathies linked to mutations in cardiac troponin I.
✕Less likely to help
Patients without genetic mutations in cardiac troponin I or those with non-genetic forms of cardiomyopathy may not benefit from this research.
What this research studies
This research focuses on understanding how mutations in cardiac troponin I (cTnI) contribute to various heart muscle diseases, including hypertrophic and dilated cardiomyopathies. The study aims to explore the mechanisms by which cTnI affects mitochondrial function, which is crucial for heart cell energy production. By using innovative peptide inhibitors, the research seeks to identify potential therapeutic strategies to mitigate heart damage caused by these mutations. Patients with inherited cardiomyopathies may benefit from insights gained through this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies for patients with inherited cardiomyopathies caused by cTnI mutations.
How similar studies have gone: Previous research has shown promising results in targeting mitochondrial dysfunction in heart diseases, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Elezaby, Aly — Stanford University
- Study coordinator: Elezaby, Aly
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.