Condition

Sudden Cardiac Death clinical trials and research

• 26Clinical trials
• 10NIH research projects
• 31Countries

Newest Sudden Cardiac Death clinical trials

All recruiting trials (26)

• Predicting sudden cardiac arrest risk in people with coronary artery disease

  This project will try to see if combining genetics, ECGs, blood biomarkers, imaging, and psychosocial information can predict which people with coronary artery disease are most likely to have sudden cardiac arrest.

  Recruiting at 3 sites Tampere Heart Hospital · Hadera and 2 other locations · NCT07444931

• Left bundle branch pacing plus ICD for people with hypertrophic cardiomyopathy after myectomy

  This study will test whether adding left bundle branch pacing to a dual‑chamber ICD helps people with hypertrophic cardiomyopathy who develop left bundle branch block after myectomy to slow heart failure progression and prevent life‑threatening arrhythmias.

  Recruiting Meshalkin Research Institute of Pathology of Circulation · Novosibirsk, Novosibirsk Oblast · NCT07372196

• Carvedilol versus metoprolol succinate in people with heart failure and an implanted defibrillator

  This study will test whether switching from metoprolol succinate to carvedilol reduces ICD therapies, heart-related hospitalizations, or cardiovascular death in adults with HFrEF and an ICD.

  Recruiting at 13 sites Phase 4 University of Rochester · Scottsdale, Arizona and 12 other locations · NCT06964464

• Understanding the connection between stroke and heart issues

  This study is trying to understand how strokes affect heart health and overall well-being in stroke patients to find new ways to help them recover better.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT06954103

• Surgery to treat myocardial bridge in coronary arteries

  This study tests if a special heart surgery can help people with symptoms from a condition called myocardial bridge feel better and improve their quality of life.

  Recruiting Xi'an International Medical Center Hospital · Xi'an, Shaanxi · NCT06857838

• Evaluating exosome multiomics and clinical outcomes in sudden cardiac death patients

  This study looks at how certain tiny particles in the blood are connected to sudden cardiac death in patients who had symptoms before their heart stopped, to help improve future care and prevention.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT06856993

• Identifying patients with cardiomyopathy for potential heart transplantation

  This study is trying to find new ways to identify and understand cardiomyopathy in patients to better predict if they might need a heart transplant in the future.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Emilia-Romagna/Bologna and 2 other locations · NCT06813443

• Identifying risk factors for sudden cardiac arrest in coronary artery disease patients

  This study is trying to find out what clinical and genetic factors might increase the risk of sudden cardiac arrest in people with coronary artery disease.

  Recruiting Tampere Heart Hospital · Tampere, Pirkanmaa · NCT06804499

• Ultrasound guidance for S‑ICD implantation

  This pilot will test whether ultrasound can replace pre‑operative X‑ray and allow intraoperative estimation of the PRAETORIAN score for patients receiving a subcutaneous ICD.

  Recruiting Universitätsklinikum Köln · Cologne, North Rhine-Westphalia and 1 other locations · NCT06771700

• Improving diagnosis of anomalous coronary arteries

  This study is testing a new online tool that uses advanced technology to help doctors better diagnose and understand the risks for patients with unusual heart artery conditions.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Italia · NCT06705751

• Genetic assessment of young athletes who experience sudden cardiac arrest during sports

  This study looks at young athletes aged 12 to 35 who have had sudden cardiac arrest during sports to see if genetic factors played a role and to help prevent similar events in others.

  Recruiting at 15 sites Rennes University Hospital · Nîmes, France and 25 other locations · NCT06642168

• Registry for hereditary cardiovascular diseases in Brazil

  This study is trying to create a registry of Brazilian patients with hereditary heart diseases to see how common certain genetic changes are in people with these conditions.

  Recruiting at 27 sites Hospital do Coracao · Rio Branco, Acre and 26 other locations · NCT06546137

• Identifying risk factors for sudden cardiac death

  This study is trying to find warning signs for sudden cardiac death in people with heart conditions by looking at different health tests and markers to help catch risks early.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guanzhou, Guangdong · NCT06440083

• Evaluation of patients using the LATITUDE monitoring system for heart devices

  This study is testing how well the LATITUDE monitoring system works for patients with heart devices to help doctors share information and improve care across Europe.

  Recruiting at 3 sites University Hospital of Ferrara · Ferrara and 2 other locations · NCT06311149

• Registry for patients with anomalous aortic origin of coronary arteries

  This study is collecting information from patients with a rare heart condition called anomalous aortic origin of coronary arteries to see how different treatments work and improve care for everyone.

  Recruiting at 2 sites University of Padova · Padova, PD and 1 other locations · NCT06089902

• AI analysis of ECGs for high-risk cardiac patients

  This study is testing an AI tool that analyzes heart rhythm patterns in high-risk heart patients to see if it can help doctors catch problems earlier and improve patient care.

  Recruiting at 2 sites Idoven 1903 S.L. · Groningen, Provincie Groningen and 12 other locations · NCT05890716

• Observing heart rhythms in patients treated with BTK inhibitors or venetoclax

  This study is testing how Bruton’s tyrosine kinase inhibitors affect heart rhythms in people with chronic lymphocytic leukemia and comparing it to those taking venetoclax to see if there are any risks.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05724121

• Monitoring the safety of MicroPort CRM heart devices

  This study is checking the long-term safety of MicroPort CRM heart devices to see how well they work and if there are any unexpected side effects for people who use them.

  Recruiting MicroPort CRM · Lisbon · NCT05694572

• Preventing sudden cardiac death after heart attacks with defibrillator implantation

  This study is testing if implantable defibrillators can help heart attack survivors with weak hearts live longer and avoid sudden cardiac death compared to just taking medications.

  Recruiting at 83 sites Charite University, Berlin, Germany · Feldkirch and 85 other locations · NCT05665608

• How transcatheter pulmonary valves interact with electrical pathways in repaired Tetralogy of Fallot

  This project will test if detailed right-ventricular electrical mapping before transcatheter pulmonary valve replacement can find conduction isthmuses that might be 'jailed' and linked to ventricular tachycardia in people with repaired Tetralogy of Fallot.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT05236153

• Registry of patients with Tetralogy of Fallot using implantable defibrillators

  This study is creating a national registry to track adult patients in France with Tetralogy of Fallot who have implantable defibrillators, to better understand their health over time.

  Recruiting Paris Sudden Death Expertise Center · Paris · NCT03837574

• Using heart tests to decide on defibrillator implantation after a heart attack

  This study tests if using heart tests can help doctors decide when to implant defibrillators in patients with weak hearts after a heart attack to prevent sudden cardiac death.

  Recruiting at 33 sites Western Sydney Local Health District · Boston, Massachusetts and 51 other locations · NCT03588286

• Registry for implantable cardiac devices

  This study is tracking how well pacemakers and defibrillators work for people with heart rhythm problems to see if they can improve patient care and outcomes.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf · NCT03360227

• Registry and biobank for arrhythmogenic ventricular cardiomyopathy

  This study is trying to gather information and samples from people with arrhythmogenic ventricular cardiomyopathy and their families to better understand the genetic causes of the condition and improve early diagnosis for those at risk.

  Recruiting at 2 sites Mayo Clinic · Rochester, Minnesota and 1 other locations · NCT03049254

• Comparing Implantable Defibrillators and Medical Therapy for Variant Angina and Sudden Cardiac Death

  This study tests if adding an implantable defibrillator to standard treatment can help people with variant angina who have survived sudden cardiac death live longer.

  Recruiting at 18 sites Phase 4 Asan Medical Center · Bucheon-si and 25 other locations · NCT02845531

• Using imaging techniques to identify risks for sudden cardiac death

  This study is testing if advanced imaging techniques like MRI and CT can help identify heart disease patients who are at high risk for sudden cardiac death and might benefit from an implantable defibrillator.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT00181233

NIH-funded research (10)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Imaging-Enhanced Prediction of Sudden Cardiac Death Risk in Pediatric Heart Disease

  Aims to create a better, non-invasive way to predict which children with hypertrophic cardiomyopathy (HCM) are at risk of sudden death so doctors can choose who truly needs an ICD.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11393844

• Dynamic predictors of sudden cardiac death in people with coronary artery disease

  Aims to improve how we predict who is at risk of sudden cardiac death by looking at changes in heart signals over time.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11366828

• KChIP2-JNK2 axis therapy for preventing sudden cardiac death

  A new approach targets how heart cells mishandle calcium to reduce dangerous heart rhythms in people at risk of sudden death.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11337630

• Finding why sudden cardiac death happens in dilated cardiomyopathy and how to stop it

  Looks at whether genetics and heart scarring can predict and help prevent deadly heart rhythms in people with dilated cardiomyopathy.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11292375

• Clonal blood-cell mutations and sudden cardiac death risk

  This project looks for a connection between clonal blood-cell mutations (CHIP) and sudden cardiac death in adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11231246

• Targeting a specific pathway to prevent sudden cardiac death in heart failure patients

  This study is looking at a specific pathway in the heart to see if it can help reduce the risk of sudden cardiac death in people with heart failure, and it hopes to find new treatments to manage dangerous heart rhythms that can happen with this condition.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11162447

• Understanding the causes of sudden cardiac death in patients with dilated cardiomyopathy.

  This study is looking at how certain genetic factors and heart changes can help doctors find out which patients with dilated cardiomyopathy are at risk for serious heart problems, so they can create better treatments and prevention plans for them.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11047759

• Investigating the link between certain blood mutations and sudden cardiac death risk

  This study is looking at how certain blood cell mutations, known as clonal hematopoiesis of indeterminate potential (CHIP), might raise the risk of serious heart problems, including sudden cardiac death, by examining genetic changes in patients who have passed away.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10995306

• Assessing sudden cardiac death risk in patients with mitral valve prolapse using advanced imaging and AI.

  This study is looking at how we can better understand the risk of sudden heart problems in people with mitral valve prolapse by using special heart imaging tests, so we can find out who might need extra care or treatment.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10814950

• Evaluating sudden cardiac death in Hispanic and Latino communities

  This study is looking at sudden cardiac arrest in Hispanic and Latino communities to find out what makes them more at risk and how we can better prevent it, using health check-ups and tests to gather important information.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-10669170

Related topics

Quick answers

How many Sudden Cardiac Death clinical trials are recruiting right now?

26, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 31 countries. The most sites are in United States (6 trials), China (4 trials), Germany (4 trials), Italy (4 trials), France (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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