Mimicking fasting effects to treat heart muscle diseases
Treating secondary cardiomyopathies by mimicking the adaptive hepatic glucose fasting response
This study is looking at how a natural sugar called trehalose might help treat heart muscle diseases by mimicking the benefits of fasting, which could protect your heart after events like heart attacks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11190523 on NIH RePORTER |
What this research studies
This research investigates how mimicking the body's response to fasting can help treat heart muscle diseases, particularly those related to cardiometabolic issues. The approach focuses on activating liver glucose metabolism, which has shown promise in animal models for protecting the heart from damage after events like heart attacks. By using a natural sugar called trehalose, the research aims to replicate the benefits of intermittent fasting, potentially leading to new therapies for patients with heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with cardiometabolic diseases or those at risk of developing heart muscle conditions.
Not a fit: Patients with non-cardiometabolic related heart issues or those who do not respond to dietary interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that protect the heart and improve outcomes for patients with cardiometabolic diseases.
How similar studies have performed: Other research has shown promising results using fasting and caloric restriction approaches in animal models, suggesting potential for success in human applications.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Debosch, Brian Jesse — Indiana University Indianapolis
- Study coordinator: Debosch, Brian Jesse
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.